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1
Content available remote

Disruption of histamine/H3 receptor signal reduces collagen deposition in cultures scar myofibroblasts

100%
Piera L., Olczak S., Kun T., Galdyszynska M., Ciosek J., Szymanski J., Drobnik J.
Journal of Physiology and Pharmacology
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2019
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tom 70
|
nr 2
2

Uterine myofibroblasts in mares

100%
Sabeckiene J., Van Ederen A. M., Zeinstra E., Aniuliene A., Gruys E.
Medycyna Weterynaryjna
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2005
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tom 61
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nr 12
3

Cellular interactions in the intestinal stem cell niche

84%
Pastula A., Marcinkiewicz J.
Archivum Immunologiae et Therapiae Experimentalis
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2019
|
tom 67
|
nr 1
4

Stromal myofibroblasts in breast cancer: relations between their occurrence, tumor grade and expression of some tumour markers

84%
Surowiak P., Suchocki S., Gyorffy B., Gansukh T., Wojnar A., Maciejczyk A., Pudelko M., Zabel M.
Folia Histochemica et Cytobiologica
|
2006
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tom 44
|
nr 2
5

A two step procedure to fractionate mouse testicular macrophages with different cytokine profiles

84%
Bryniarski K., Szewczyk K., Ptak M., Bobek M., Ptak W.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
tom 50
|
nr 3
6

Direct in vivo transfer of plasmid DNA into murine tumors: Effects of endotoxin presence and transgene localization

84%
Budryk M., Cichon T., Szala S.
Acta Biochimica Polonica
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2001
|
tom 48
|
nr 3
The purpose of this study was to investigate the effect of endotoxin presence in plasmid DNA preparations on the efficiency of transfection achieved in vivo with B16(F10) and Renca tumors and to determine transgene localization. Our data show that endotoxin markedly decreases the efficiency of transfection. Furthermore, the transgene transferred in vivo can be found in both neoplastic and normal (most likely myofibroblast) cells lying in proximity of the administration site.
7

mRNA and protein expression of FGF-1, FGF-2 and their receptors in the porcine umbilical cord during pregnancy

67%
Chrusciel M., Rekawiecki R., Ziecik A., Andronowska A.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 4
8
Content available remote

Molecular alterations in fibroblasts exposed to Helicobacter pylori: a missing link in bacterial inflammation progressing into gastric carcinogenesis?

67%
Krzysiek-Maczka G., Targosz A., Ptak-Belowska A., Korbut E., Szczyrk U., Strzalka M., Brzozowski T.
Journal of Physiology and Pharmacology
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2013
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tom 64
|
nr 1
9

Different distribution of c-kit positive interstitial cells of Cajal-like in children’s urinary bladders

67%
Piaseczna-Piotrowska A. M., Dzieniecka M., Kulig A., Danilewicz M., Chilarski A.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 3
10
Content available remote

Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar

67%
Drobnik J., Slotwinska D., Olczak S., Tosik D., Pieniazek A., Matczak K., Koceva-Chyla A., Szczepanowska A.
Journal of Physiology and Pharmacology
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2011
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tom 62
|
nr 1
The aim of the study was to define the effect of pharmacological doses of melatonin, an agent known to be a scavenger of reactive oxygen species, on the extracellular matrix composition (glycosaminoglycans and collagen) in the infarcted heart scar. Rats were administered with melatonin at doses of 300 µg/100 g b.w. or 3 mg/100 g b.w. once daily (between 5:00 and 6:00 in the afternoon) or with 1.5 mg/100 g b.w. twice daily (between 8:00 and 9:00 in the morning and additionally between 5:00 and 6:00 in the afternoon). The levels of collagen, glycosaminoglycans (GAG) and some oxidative stress markers (lipid oxidation, the content of sulphydryl groups in proteins and glutathione) were evaluated. In the second part of the experiment, cells were isolated from the scar, identified as myofibroblasts, cultured and treated with melatonin at concentrations ranging from 10-7M to 10-10M. The pineal indoleamine was seen to reduce the GAG content of the scar, while the collagen content of the scar remained unchanged. A 10-7M concentration of melatonin caused an increase in the GAG level in the myofibroblast cultures, while lower concentrations (10-8M-10-10M) of pineal indoleamine were not effective. Melatonin decreased lipid oxidation and increased the sulphydryl groups of total proteins and glutathione, which suggests its antioxidative activity in the applied doses. The present study shows that pharmacological doses of melatonin reduce the GAG level in an infarcted heart scar. Since the mechanism of GAG content reduction cannot be explained by direct action of the pineal indoleamine on myofibroblasts in the myocardial infarction scar, we hypothesise that changes in GAG content could be indirectly induced by melatonin, that is caused by changes in regulatory systems or reduction of the inflammatory reaction in the area of the infarction. In addition, this paper shows that long-term treatment with melatonin of rats affected by myocardial infarction may reduce oxidative stress in the infarction area.
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