Wyniki wyszukiwania

1

Differentiation of the human myocardium (trabeculation and compaction) during early intrauterine period

100%

Rauhut-Klaban M., Bruska M.

Acta Biologica Cracoviensia. Series Botanica. Supplement

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2008

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tom 50

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nr 1

2

Effect of constant magnetic field on myocardium activity in larvae of trout (Salmo trutta L.)

100%

Winnicki A., Formicki K.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1990

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tom 38

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nr 1-12

3

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Myocardial calcium compartmentation and contractile control

100%

Langer G. A.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 1

Under the condition of rapid perfusion, the time course of contractile response of single ventricular cells to extracellular calcium (Ca) depletion and repletion identifies „fast” and „slow” cellular Ca pools. ⁴⁵Ca exchange was studied in these cells under the same conditions of on-line rapid perfusion. Four kinetically-defined compartments were distinguished: (1) A „rapid” compartment containing 2.6mmoles Ca/kg dry wt of lanthanum (La) displaceable Ca, t½ < 1 sec.; (2) An „intermediate” compartments) containing 2.1 mmoles, t½ = 3 and 19 sec. Caffeine displaced significant amounts of Ca from this compartment whereas La displaced none; (3) A „slow” compartment containing 1.6 mmoles, t½ = 3.6 min. Addition of inorganic phosphate to the perfusate adds significant amounts of Ca to this compartment; (4) An „inexchangeable” compartment, containing 1.2 mmoles. The „rapid” compartment’s flux is > 300 µmoles Ca/kg wet wt/sec. Its exchange rate indicates that it is the kinetic counterpart of the functionally-defined „fast” pool. Its subcellular locus is undefined. The „intermediate” compartment is best correlated with the „slow” pool and represents Ca in the sarcoplasmic reticulum. The „slow” compartment contains a significant fraction from the mitochondria. The results indicate that > 40% of cellular Ca can turn over within the period of one contraction cycle. These results are consistent with the following sequence: (1) Upon sarcolemmal depolarization, Ca moves through the Ca channel to arrive at the SR and at the myofilaments. (2) Ca induced Ca release occurs via the „feet” at the SR-inner SL region. The Ca diffuses to the myofilaments or is transported across the SL via the Na-Ca exchanger. (3) Ca is pumped into the free or longitudinal SR and diffuses to the cistemae. Ca is pumped across the SL by the SL Ca pump and by the Na-Ca exchanger. (4) Mitochondrial Ca exchange via the Na-Ca exchanger and/or SL Ca pump. (Supported by NHLBI and the Laubisch and Castera Endowments.)

4

Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats

100%

Ahmad A., Sattar M. A., Rathore H. A., Abdulla M. H., Khan S. A., Abdullah N. A., Johns E. J.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 1

5

Hypercholesterolemia antagonized heart adaptation and functional remodeling of the mitochondria observed in acute diabetes mellitus subjected to ischemia/reperfusion injury

100%

Ferko M., Farkasova V., Jasova M., Kancirova I., Ravingerova T., Duris Adameova A., Andelova N., Waczulikova I.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

6

Effects of calmidazolium, carbachol and derivatives of cyclic GMP on the longitudinal internal resistivity in rabbit atrial trabeculae

100%

Tuganowski W.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 4

The effects of calmidazolium, carbachol and membrane permeable derivatives of cGMP (dipalmitoyl cGMP and 8-Bromo cGMP) on the longitudinal internal resistivity (Ri) were studied in the rabbit atiial trabeculae by means of electrophysiological recording techniques and histological planimetry. Calmidazolium as well as carbachol decreased Ri whereas cGMP-derivatives enhanced this resistivity. The effect of calmidazolium suggested that calmodulin reduced the cell coupling under control conditions. Carbachol decreased the Ca-inward current, and probably it prevented the calmodulin activation. The action of the nucleotides showed that cGMP did not mediate the cholinergic effect on the cell coupling. The possible interaction between calmodulin and cGMP was discussed.

7

The effect of a diet fortified with polyunsaturated fatty acid on the level of selected elements in the myocardium of growing pigs

100%

Sawosz E., Kowalczyk E., Hotowy A., Lechowski R., Kleczkowski M., Fabijanska M.

Journal of Animal and Feed Sciences. Supplement

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2001

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tom 10

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nr 2

8

The role of longitudinal shortening in the general pattern of heart left ventricle contraction

100%

Gorycki T., Bobek-Billewicz B., Galazka R., Hermann M.

Folia Morphologica

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2000

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tom 59

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nr 1

This paper constitutes a report of our experience in the assessment of left ventricle contraction using MRI (Philips 0,5T Gyroscan T5/II) and includes a suggestion of the study method directed towards establishing the role of different patterns of ventricle contraction in general ventricle function. In 29 patients, 22 men and 7 women, (average age 55.3) with history of myocardial infarction, electrocardiographically gated MR images encompassing the entire heart in the anatomic long and short axis planes were acquired. Significant positive correlations between long axis shortening and area length ejection fraction were found on four chamber view images: r = 0.605 at p<0.05 and on two chamber view images: r = 0.554 at p<0.05.

9

Effect of heat stress on mitochondrial adenine nucleotide pools in rat myocardium

100%

Sammut I. A., Jayakumar J., Yacoub M. H., Smolenski R. T.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

10

Angioarchitectonics of the venous vessels in the normal human myocardium

84%

Ratajczyk-Pakalska E., Bloch P., Kulig A.

Folia Morphologica

|

1990

|

tom 49

|

nr 1-2

11

Exposure to sixty minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease - a pilot study

84%

Karu I., Tahepold P., Ruusalepp A., Reimann E., Koks S., Starkopf J.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 6

12

Peroxisome proliferator-activated receptor alpha activation inducesunfavourable changes in fatty acid composition of myocardial phospholipids

84%

Baranowski M., Blachnio-Zabielska A., Gorski J.

Journal of Physiology and Pharmacology

|

2009

|

tom 60

|

nr 2

13-20

Peroxisome proliferator-activated receptor alpha (PPAR) plays a crucial role in the transcriptional regulation of myocardial lipid metabolism. In vitro studies on isolated cardiomyocytes showed that PPAR activation induces expression of numerous genes involved in virtually all steps of fatty acid catabolism. However, there is very few data on the effect of PPAR activation on the content and composition of myocardial lipids in vivo. Therefore, our main aim was to examine effects of selective PPAR agonist WY-14643 on the content and fatty acid composition of major lipid classes in the heart of rats fed a standard chow (STD) or a high-fat diet (HFD). In STD rats WY-14643 paradoxically decreased palmitate oxidation rate in the heart, however, in HFD animals such effect was not observed. WY-14643 markedly reduced myocardial free fatty acid and diacylglycerol content in STD rats, whereas in HFD group the opposite effect was observed. These changes reflected alterations in plasma lipid concentration which suggests that effects of WY-14643 on the heart were indirect and secondary to changes in plasma lipid availability induced by the drug. Basal myocardial glucose uptake was not affected by PPAR agonist in either group, however, glycogen content in the heart was markedly increased. WY-14643 exerted profound influence on the fatty acid composition of myocardial phospholipids in both diet groups. These changes included increased percentage of monounsaturated fatty acids and replacement of n-3 polyunsaturated fatty acids (PUFA) by those from the n-6 family. This action of WY-14643 might be detrimental to the heart since n-3 PUFA possess cardioprotective and antiarrhythmic properties.

13

ANP [Atrial Natriuretic Peptide] presence in the heart of a tunicate, Ciona intestinalis

84%

Lipari L., Gerbino A., Lipari D., Farina E. V.

Folia Histochemica et Cytobiologica

|

2010

|

tom 48

|

nr 1

68-70

14

Tetrodotoxin blocks native cardiac L-type calcium channels but not Cav1.2 channels expressed in HEK cells

84%

Szentandrassy N., Papp F., Hegyi B., Bartok A., Krasznai Z., Nanasi P. P.

Journal of Physiology and Pharmacology

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2013

|

tom 64

|

nr 6

15

Changes of hydroxyproline levels in myocardium after chronic administration of bleomycin

84%

Anasiewicz A., Wojcik K., Abramowicz K., Lakowska H., Bentkowski M., Przywra S., Radzikowska E.

Folia Morphologica

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1996

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tom 55

|

nr 4

16

The effect of melatonin on the cytotoxic effects of doxorubicin on the myocardium and on transplantable Morris hepatoma in rats

84%

Dziegiel P., Podhorska-Okolow M., Surowiak P., Ciesielska U., Rabczynski J., Zabel M.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

17

ATP-loaded liposomes and immunoliposomes protect ischemic myocardium in isolated rat hearts and in rabbits with experimental myocardial infarction

84%

Torchilin V. P., Verma D. D., Levchenko T. S., Hartner W. C., Bernstein E. A.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.

18

Reactivity of isolated human right atria to norepinephrine in various disease states

84%

Golba K. S., Deja M., Wos S., Bachowski R., Szalanski P., Mrozek R., Herman Z. S.

Journal of Physiology and Pharmacology

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1995

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tom 46

|

nr 3

19

Changes of nucleotide content in human and rat heart during cardiac surgery and ischemia

84%

Smolenski R. T., Skladanowski A. C., Swierczynski J., Perko M., Narkiewicz M., Zydowo M. M.

Acta Biochimica Polonica

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1993

|

tom 40

|

nr 4

The influence of ischemia on purine nucleotide and their catabolite concentration in human myocardium was investigated during surgery of acquired and congenital heart defects. This was compared with the influence of ischemia on rat heart. Concentrations of adenine and guanine nucleotides and their catabolites were measured in the extracts of heart biopsies taken at the onset of ischemia and at the time of reperfusion. The content of myocardial ATP in human heart decreased from the initial value of 223 ± 1.1 to 14.6 ±1.5 nmol/mg protein and total adenine nucleotide pool decreased from 34.2 ± 1.8 to 27.6 ± 1.5 nmol/mg protein during the operation. Significant increases in myocardial concentrations of purine catabolites were also observed with the most prominent rise in inosine from below 0.5 at the onset of the ischemia to 3.0 ± 0.5 nmol/mg protein at the time of reperfusion. A positive correlation was demonstrated between the concentration of purine catabolites in the heart at the end of ischemia with the decrease of both ATP and the total nucleotide pool. An interesting metabolic specificity of the ischemic human heart appeared to be only a small accumulation of inosine monophospahate (IMP). The increase of IMP in the rat heart after ischemia was several-fold higher.

20

Arrhythmias in programmed electrical stimulation in the course of experimentally induced hyperthyroidism in an animal model

84%

Noszczyk-Nowak A., Gajek J., Paslawska U., Skrzypczak P., Zysko D., Nicpon J.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 1

To determine changes in physiological parameters of the myocardium in experimentally induced hyperthyreosis in an animal model, the occurrence and type of arrhythmias triggered during programmed electrical stimulation and changes in electrophysiological parameters of ventricular cardiomyocytes with hypertrophy due to hyperthyreosis were investigated. Hyperthyreosis was induced experimentally in five pigs, which were orally administered L-thyroxine at a dose of 20 µg/kg. Five untreated pigs served as the control. Programmed electrical stimulation was performed before administration of L-thyroxine (EPS 1), four (EPS 2) and eight (EPS 3) weeks after the onset of thyroxine administration, and four weeks after drug withdrawal (EPS 4). After the last stimulation, the animals were sacrificed and necropsied, with particular regard to heart autopsy. During the EPS 2, VERP was decreased in the group treated with the hormone (P<0.05). The mean values of AERP and AVNERP in the group were decreased as well. Atrial flutter and atrial fibrillation were induced during stimulation of the experimental group. In the other pigs of the experimental group, singular and paired ventricular extrasystolic were observed. In the EPS 3, AERP and AVNERP were statistically shorter in pigs with hyperthyreosis. A significant difference in Wenckebach CL between the control and experimental groups were observed. SNRT was shorter in the group with hyperthyreosis. In all pigs with hyperthyreosis, atrial fibrillation was induced. In one pig, non-sustained ventricular tachycardia was observed. During EPS 4, AERP remained shorter in group with hyperthyreosis. In two pigs of the group, atrial fibrillation was induced during pacing, and in two pigs, ventricular fibrillation was observed. The assessment of the heart's weight revealed a significant increase in its mass in pigs with hyperthyreosis. An increase in the thickness of the right and left ventricle free walls (P<0.01) and interventricular septum (P<0.01) was found in pigs with hyperthyreosis. At the same time, the inner diameter of the left ventricle was significantly smaller in this group (P<0.01) due to a concentric hypertrophy of the ventricle. In view of these findings, experimental hyperthyreosis caused shortening of refractory periods of different parts of the conducting system and enhanced susceptibility to supraventricular and ventricular arrhythmias, both spontaneous and induced during electrical stimulation. The mechanism of these arrhythmias can differ as a consequence of the hypertrophy of the left ventricle.

Ograniczanie wyników

Differentiation of the human myocardium (trabeculation and compaction) during early intrauterine period

Effect of constant magnetic field on myocardium activity in larvae of trout (Salmo trutta L.)

Myocardial calcium compartmentation and contractile control

Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats

Hypercholesterolemia antagonized heart adaptation and functional remodeling of the mitochondria observed in acute diabetes mellitus subjected to ischemia/reperfusion injury

Effects of calmidazolium, carbachol and derivatives of cyclic GMP on the longitudinal internal resistivity in rabbit atrial trabeculae

The effect of a diet fortified with polyunsaturated fatty acid on the level of selected elements in the myocardium of growing pigs

The role of longitudinal shortening in the general pattern of heart left ventricle contraction

Effect of heat stress on mitochondrial adenine nucleotide pools in rat myocardium

Angioarchitectonics of the venous vessels in the normal human myocardium

Exposure to sixty minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease - a pilot study

Peroxisome proliferator-activated receptor alpha activation inducesunfavourable changes in fatty acid composition of myocardial phospholipids