Wyniki wyszukiwania

1

Mutagen-induced chromosome instability in farm animals

100%

Danielak-Czech B., Slota E.

Journal of Animal and Feed Sciences

|

2004

|

tom 13

|

nr 2

257-267

2

Efficiency of selected mutagens in generating Xanthophyllomyces dendrorhous strains hyperproducing astaxanthin

86%

Stachowiak B.

Polish Journal of Microbiology

|

2013

|

tom 62

|

nr 1

Astaxanthin is a xanthophill pigment with commercial application in the aquaculture, pharmaceutical, food and cosmetic industries. The red yeast Xanthophyllomyces dendrorhous is one of the most promising microorganisms for its industrial production. However, astaxanthin content in wild yeast strains is low. Pigment production by X. dendrorhous can be improved by mutagenesis. The aim of the study was to assess the efficiency of four mutagens: UV radiation, benomyl, ethyl methanesulfonate and ethidium bromide in generating asthaxanthinhyperproducing strains of the yeast Xanthophyllomyces dendrorhous DSM 5626. Mutations with benomyl, ethidium bromide and UV radiation generated a group of hyperpigmented mutants exhibiting increases up to 100% in astaxanthin content. Ethyl methanesulfonate turned out to be useless in this respect.

3

Mutagenicity of carboline methyl derivatives in Salmonella

86%

Rahden-Staron I., Peczynska-Czoch W., Kaczmarek L.

Acta Microbiologica Polonica

|

1994

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tom 43

|

nr 2

4

Chromosome and genome mutations caused by toxic metal

72%

Dovgalyuk A., Kalynyak T., Blume Y.

Biological Bulletin of Poznań. Supplement

|

1997

|

tom 34

5

Genome heterogeneity in mutagen - induced DNA repair

72%

Szyfer K., Mullenders L. H. M.

Current Topics in Biophysics

|

1992

|

tom 16

|

nr 2

6

DNA-damaging effect of cadmium and protective action of quercetin

72%

Blasiak J.

Polish Journal of Environmental Studies

|

2001

|

tom 10

|

nr 6

Cadmium is a widespread environmental and occupational pollutant and quercetin is a dietary flavonoid, which is reported to modulate the effects of many mutagens and carcinogens. We investigated the ability of cadmium chloride to induce DNA damage in human lymphocytes in the presence of quercetin using the alkaline comet assay. Cadmium chloride (5-150 muM) evoked dose-dependent DNA damage and quercetin at 50 muM decreased the extent of the damage. The lymphocytes exposed to cadmium chloride were able to remove their DNA damage within a time period shorter than 120 min. The cells treated with quercetin at 50 muM prior to exposure to cadmium required shorter periods of time to recover. Quercetin could chelate cadmium ions, scavenge free radicals produced by cadmium or regenerate cellular DNA-repair enzymes.

7

Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

72%

Ulanowska K., Wegrzyn G.

Journal of Applied Genetics

|

2006

|

tom 47

|

nr 1

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin, which can damage dopaminergic neurons. It causes symptoms resembling those observed in patients suffering from Parkinson’s disease, and hence this toxin is widely used in studies on animal models of this disorder. Mutagenicity of MPTP was also reported by some authors, but results obtained by others suggested that this compound is not mutagenic. Interestingly, those contrasting results were based on the same assay (the Ames test). Therefore, we aimed to test MPTP mutagenicity by employing a recently developed Vibrio harveyi assay, which was demonstrated previously to be more sensitive than the Ames test, at least for some mutagens. We found that MPTP showed a significant mutagenic activity. Moreover, MPTP mutagenicity was attenuated by methylxanthines, compounds that are known to form complexes with aromatic mutagens.

8

Antioxidative properties of some vegetable products traditional for diets in Central Europe - short report

72%

Bartoszek A., Forc A., Grzeskowiak J.

Polish Journal of Food and Nutrition Sciences

|

2002

|

tom 11/52

|

nr 4

The results of epidemiological studies published in the 70s suggested that diets of certain Central European states might contain unique chemo- preventive components. We investigated the antioxidative properties of traditional foods such as sauerkraut or beet roots, typical for diets in Central Europe and less common in other parts of the world. Some of the foods tested displayed free radical scavenging activity comparable to green tea used as a positive control. Particularly effective in this regard were beet root concentrate, sauerkraut juice and fermented cucumbers. Additionally, comet assay showed that sauerkraut juice protected cultured HL-60 cells against oxidative DNA damage in a dose-dependent manner.

9

Prof.dr.habil.Grzegorz Nowak [1946-2002]

72%

Polish Journal of Natural Sciences

|

2002

|

tom 10

10

Respiratory deficient mutants of xylose-fermenting yeast - obtainment and features

58%

Chmielewska J., Dziuba E.

Electronic Journal of Polish Agricultural Universities. Series: Biotechnology

|

2003

|

tom 06

|

nr 2

11

Wykorzystanie samoplodnych linii wsobnych zyta ozimego [ S.cereale L.] do indukowania mutacji

58%

Kubicka H., Malepszy S.

Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin

|

1996

|

tom 197

89-95

12

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Frequency and spectrum of induced viable macromutations in chickpea (Cicer arietinum L.) cultivar ‘Vishwas’

58%

Barshile J. D.

International Letters of Natural Sciences

|

2015

|

tom 03

Present investigation was undertaken to study the frequency and spectrum of induced viable macromutations employing SA, EMS and gamma radiation in chickpea (Cicer arietinum L.) cultivar Vishwas (Phule G 5). The seeds of chickpea, cultivar Vishwas were treated with three different concentrations / doses of SA (2, 3 and 4 mM), EMS (8, 12 and 16 mM) and gamma radiations (400, 500 and 600 Gy). The mutagen administered seeds were sown in experimental fields to raise M1 progeny. Seeds of M1 plants and control were harvested separately and sown to raise M2 population. The M2 progeny were screened for viable macromutaions. A wide spectrum of viable macromutations was isolated in the M2 generation. In all twenty four different types of viable morphological macromutations were observed. These included 7 types of plant type mutations and 6 types of leaf mutations, 1 types of flower mutation, 5 types of pod mutation and 5 types of seed mutations. Results indicated that all mutagenic treatments were effective in inducing viable mutations in chickpea, during M2 generation. Differences in response to different mutagens were observed in the spectrum and frequency of viable mutations. Some mutation types occurred more frequently than others. The frequency and spectrum of viable mutations were relatively high with EMS followed by gamma radiation and SA. In the present investigation, an attempt has been made for increasing frequency and spectrum of locally important chickpea cultivar ‘Vishwas’ employing chemical and physical mutagens.

13

Estimation of induced mutation rates of four esterase genes in barley [Hordeum vulgare L.]

58%

Kucharska M., Maluszynski M.

Journal of Applied Genetics

|

1998

|

tom 39

|

nr 2

Induced mutation rate of barley esterase loci has been estimated. Results suggested that about 3% of investigated M₁ spikes had seeds which gave rise to M₂ seedlings mutated in one of four esterase loci. M₁ plants were obtained after chemical treatment of seeds from two spring barley cultivars Aramir and Bielik. The majority of mutants were reconfirmed in the М₃ generation.

14

Germ cell mutagenesis in Drosophila: Multiple endpoint analysis

58%

Nivard M. J. M., Wijen J., Vogel E. W.

Acta Biochimica Polonica

|

1998

|

tom 45

|

nr 2

Genotoxic carcinogens, able to damage DNA by alkylation reactions, represent a very diverse class of agents which are capable of producing a wide range of DNA modifications. The mechanisms leading to genetic changes as a result of exposure to alkylating agents (AAs) have been studied in male germ cells of Drosophila using a structure-activity relationship approach (SAR). The analytical tools available concern both genetic and molecular assays. The genetic tests enable to quantify excision repair and clastogenic potency of the AA after treatment of post-meiotic male germ cells and to determine the degree of germ-cell specificity, i.e., the mutagenic effectiveness in post-versus premeiotic cell stages. For a selected group of alkylating agents the molecular spectra have been studied in post-meiotic cell stages. On the basis of these descriptors clear SAR's between genotoxic activity in germ cells and physico-chemical parameters (s-values and O6/N7-alkylguanine adducts) and carcinogenic potency in rodents became apparent, resulting in five distinct classes of alkylating agents so far. These classes are: 1) SN2-type monofunctional AAs, 2) SN1-type monofunctional AAs, 3) polyfunctional AAs, 4) agents able to form etheno-DNA adducts, and 5) aflatoxin B1 (AFB1) a bulky-adduct forming agent. The recent finding that the molecular data obtained with Drosophila and data of the specific locus tests in male mice show remarkable similarities for most genotoxic agents supports the view that Drosophila is a useful model system for the study of transgenerational damage.

15

Influence of magnetic field with chemomutagen and gamma rays on the variability of yielding parameters in barley [Hordeum vulgare L.]

58%

Rybinski W., Pietruszewski S., Kornarzynski K.

International Agrophysics

|

2003

|

tom 17

|

nr 2

16

DNA damage induced by mutagens in plant and human cell nuclei in acellular comet assay

58%

Juchimiuk J., Gnys A., Maluszynska J.

Folia Histochemica et Cytobiologica

|

2006

|

tom 44

|

nr 2

17

Oznaczanie aktywnosci mutagennej ekstraktu cykloheksanowego pylu powietrza atmosferycznego i wielopierscieniowych weglowodorow aromatycznych [WWA] przy uzyciu roznych szczepow Drosophila malanogaster

51%

Krogulski A., Borkowska M., Strusinski A.

Roczniki Państwowego Zakładu Higieny

|

1998

|

tom 49

|

nr 3

279-283

Przedstawiono wyniki oznaczania aktywności mutagennej ekstraktu cyklohek- sanowego pyłu powietrza atmosferycznego oraz wybranych wielopierścieniowych węglowodorów aromatycznych. W badaniach użyto różnych szczepów Drosophila melanogaster różniących się poziomem enzymów związanych z cytochromem P-450.

18

Evaluation of the SOS chromotest for detection of genotoxic drugs

51%

Marczewska J., Chlopkiewicz B., Ejchart A., Koziorowska J.

Acta Microbiologica Polonica

|

1993

|

tom 42

|

nr 2

19

Uwarunkowania strukturalnej niestabilnosci chromosomow bydla

44%

Danielak-Czech B.

Biuletyn Informacyjny. Instytut Zootechniki

|

2001

|

tom 39

|

nr 4

5-14

20

Analiza cech ilosciowych roslin pokolenia M1 jeczmienia uzyskanych dzialaniem swiatla lasera i azydku sodu

44%

Adamska E., Rybinski W.

Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin

|

2000

|

tom 216

|

nr 1

213-219

Ograniczanie wyników

Mutagen-induced chromosome instability in farm animals

Efficiency of selected mutagens in generating Xanthophyllomyces dendrorhous strains hyperproducing astaxanthin

Mutagenicity of carboline methyl derivatives in Salmonella

Chromosome and genome mutations caused by toxic metal

Genome heterogeneity in mutagen - induced DNA repair

DNA-damaging effect of cadmium and protective action of quercetin

Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Antioxidative properties of some vegetable products traditional for diets in Central Europe - short report

Prof.dr.habil.Grzegorz Nowak [1946-2002]

Respiratory deficient mutants of xylose-fermenting yeast - obtainment and features

Wykorzystanie samoplodnych linii wsobnych zyta ozimego [ S.cereale L.] do indukowania mutacji

Frequency and spectrum of induced viable macromutations in chickpea (Cicer arietinum L.) cultivar ‘Vishwas’

Estimation of induced mutation rates of four esterase genes in barley [Hordeum vulgare L.]

Germ cell mutagenesis in Drosophila: Multiple endpoint analysis

Influence of magnetic field with chemomutagen and gamma rays on the variability of yielding parameters in barley [Hordeum vulgare L.]

DNA damage induced by mutagens in plant and human cell nuclei in acellular comet assay

Oznaczanie aktywnosci mutagennej ekstraktu cykloheksanowego pylu powietrza atmosferycznego i wielopierscieniowych weglowodorow aromatycznych [WWA] przy uzyciu roznych szczepow Drosophila malanogaster

Evaluation of the SOS chromotest for detection of genotoxic drugs

Uwarunkowania strukturalnej niestabilnosci chromosomow bydla

Analiza cech ilosciowych roslin pokolenia M1 jeczmienia uzyskanych dzialaniem swiatla lasera i azydku sodu