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Mucosal vaccination - an old but still vital strategy

100%

Dlugonska H., Grzybowski M.

Annals of Parasitology

2012

tom 58

nr 1

The basic premise of vaccinology is to achieve strong protective immunity against defined infectious agents by a vaccine mimicking the effects of natural primary exposure to a pathogen. Because an exposure of humans and animals to microbes occurs mostly through mucosal surfaces, targeting the mucosa seems a rational and efficient vaccination strategy. Many experimental and clinical data confirmed that mucosal immunization offers many advantages over widely used in human and veterinary medicine subcutaneous or intramuscular immunization. In the present article selected aspects regarding mucosal vaccination are discussed. The structure and function of mucosaassociated lymphoid tissue (MALT), comprised of four main mucosal compartments forming a structural and functional unity as well as pivotal cellular MALT components (dendritic and M cells) were briefly characterized. Particular attention was focused on the mode of simple but efficacious delivery of vaccine antigens to mucosal surfaces. A few trials to generate potential mucosal vaccines against toxoplasmosis introduced by nasal or oral routes to experimental animals are also presented.

Perspectives of anti-H.pylori vaccination

100%

Saldinger P. F., Blum A. L., Corthesy-Theulaz I. E.

Journal of Physiology and Pharmacology. Supplement

1997

tom 48

nr 4

Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens

80%

Gosselin E. J., Bitsaktsis C., Li Y., Iglesias B. V.

Archivum Immunologiae et Therapiae Experimentalis

2009

tom 57

nr 5

311-323

Ograniczanie wyników

1 Annals of Parasitology

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Physiology and Pharmacology. Supplement

1 Bitsaktsis C.

1 Blum A. L.

1 Corthesy-Theulaz I. E.

1 Dlugonska H.

1 Gosselin E. J.

1 Grzybowski M.

1 Iglesias B. V.

1 Li Y.

1 Saldinger P. F.

1 2012

1 2009

1 1997

Wyniki wyszukiwania

Mucosal vaccination - an old but still vital strategy

Perspectives of anti-H.pylori vaccination

Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens