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Molecular aspects of effect of Shiga toxin in humans - a Review

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Pal P.

International Letters of Natural Sciences

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2015

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tom 07

Shiga toxins belonging to a family of structurally and functionally related protein toxins serve as the key virulence factors for pathogenecity of the virulent enteric bacterial strains namely Shigella dysenteriae serotype 1 including Shiga toxin-producing Escherichia coli (STEC). S. dysenteriae type 1 isolates remain major public health concerns due to their widespread outbreaks and the severity of extra-intestinal diseases, including acute renal failure and also affects the central nervous system. Despite practicing improved hygienic conditions and regulating food and drinking water safety, the enteric pathogens are imposing a major threat in the well being of the human society. Shiga toxin on entry into host cells’ endoplasmic reticulum (ER) activates the stress response in ER and inhibits protein synthesis by catalytic inactivation of eukaryotic ribosomes. In many cell types shiga toxins trigger apoptosis. Recent studies have shown that shiga toxins induce autophagy which activates different signaling pathways in toxin-sensitive and toxin-resistant human cells. In this review the molecular basis of Shiga toxins’ effect on host cell leading to manifestation of the infection in affected individuals are discussed with an emphasis on recent findings.

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Aktivacionnye processy pri sushke drevesiny

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Princevskaja E., Olejjnik R., Spirochkin A.

Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology

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2013

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tom 84

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Oral squamous cell carcinoma (OSCC) - molecular, viral and bacterial concepts

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Polz-Gruszka D., Macielag P., Foltyn S., Polz-Dacewicz M.

Journal of Pre-Clinical and Clinical Research

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2014

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tom 08

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nr 2

Head and neck cancers constitute the sixth most common malignant tumours worldwide, and are one of the majors problems of global public health. In the oral cavity there are several types of oral cancers, but around 90% are squamous cell carcinoma. Many different risk factors play a role in the etiology of head and neck cancer. The aim of this study is presentation from the aspect of molecular, viral and bacterial infection. Knowledge about all factors which influence the development of these malignances is essential for diagnostics and successful treatment.

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Molecular and environmental aspects of skin cancers

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Zebracka A., Matysiak M., Dudra-Jastrzebska M., Kapka-Skrzypczak L.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 2

Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.

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Molecular and physiological aspects of the role of root hairs during drought stress in barley

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Kwasniewski M., Daszkowska-Golec A., Chwialkowska K., Janiak A., Szarejko I.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

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Genetic characterization of some rhizobial isolates from various legumes

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El-Ghany E. M. A., Eissa R. A., Fahmi A. I., Nagaty H. H., El-Zanaty A. M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2020

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tom 101

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nr 3

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Plant cell responses to heavy metals: molecular and physiological aspects

72%

Gwozdz E. A., Przymusinski R., Rucinska R., Deckert J.

Biological Bulletin of Poznań. Supplement

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1997

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tom 34