This study was designed to evaluate the changes in adenylate levels, adenylate energy charge (AEC) and glycolytic enzymes in control and infected mice and treatment with Citrus reticulata or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid), as a new antischistosomal drug. Alternations in the hepatic content of adenine nucleotides (ATP, ADP and AMP), Pi, phosphate potential, AEC, glucose, glycogen, AMP-deaminase, adenosine deaminase and total protein contents were investigated in a trial to point out the effect of infection with Schistosoma mansoni parasite as a hypoxia inducer in mice liver tissues. Moreover, the role of Citrus reticulata and Commiphora (Mirazid), natural plant extracts in improving the energy status in S. mansoni infected mice was studied, since Citrus reticulata was previously reported to possess anti-leukemia, antimicrobial and antibacterial activities, whereas Commiphora extract (Mirazid) – antifasciolicidal ones.
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