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1

Krotkotrwale znieczulenie psow przy uzyciu midazolamu i ksylazyny

100%
Balicki I., Rozanska D., Cwiek A., Silmanowicz P., Szponder T., Brodzki A.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 01
72-74
Clinical practice with small animals often requires the immediate introduction of the patient to short-acting anaesthesia. The aim of the study was the evaluation of the use of midazolam and xylazine as short-acting anaesthesia for dogs. The investigation was carried out on 27 dogs. The general anaesthesia was performed by using a mixture including: atropine 0.05 mg/kg, xylazine 1 mg/kg and midazolam 0.3 mg/kg. The drugs were administered intravenously by using one syringe at a dose dependant on the effects of the operation. Anaesthesia was evaluated testing palpebral reflex, corneal reflex, superficial sensibility and pedal reflex. Body temperature, heart rate, respiratory rate, parameters of acid-base balance and blood oxyganation were determined during anaesthesia. Intravenous administration of atropine, xylazine and midazolam at a dose dependant on the effects of the operation induce general anaesthesia lasting about 20 minutes. The anaesthesia was connected with the loss of consciousness and pain sensitivity. This kind of anaesthesia causes transient acid-base balance disturbances and respiratory depression. The method of anaesthesia used in our study provides fast induction and recovery without antagonists. The negative effect on the anaesthetised animals was minimal.
2

Stan padaczkowy? Midazolam możesz podać również donosowo!

100%
Kalwas-Sliwinska M.
Magazyn Weterynaryjny
|
2020
|
tom 29
|
nr 02
3

Comparative study of midazolam-propofol and metamizole-propofol clinical effects in domestic pigeons

84%
Mousavi A., Abedi G., Jahandideh A., Hesaraki S.
Medycyna Weterynaryjna
|
2018
|
tom 74
|
nr 09
This study was conducted to determine the quality of anesthesia by evaluating the clinical effects of midazolam-propofol and metamizole-propofol on domestic pigeons (Columba livia). The aim of the study was to choose an appropriate injectable anesthetic protocol by utilizing midazolam and metamizole as pre-anesthetic drugs in order to reduce the dose of propofol and decrease side effects. Eighteen male pigeons weighing 304.2 ± 32.3 g (mean ± SD) were randomly allocated to three groups of six pigeons each. Midazolam (6 mg/kg/IM) and metamizole (500 mg/kg/IM) were used five minutes prior to administration of propofol (8 mg/kg/IV) in groups I and II, respectively, while the birds in group III (control group) received metamizole (500 mg/kg/IM). Five minutes after the last injection, clinical parameters of various systems were evaluated. Nervous system parameters declined in groups I and II, while reflexes could still be elicited in group III (P < 0.05). There were no significant changes in the heart rate, dysrhythmia, or gastrointestinal parameters in the three groups (P > 0.05). The birds in group II showed reduced jaw and limb muscle tone (P < 0.05). Corneal and palpebral reflexes were absent in groups I and II (P < 0.05). Both respiratory depth and pattern were irregular in group I, while all the parameters were normal in group II (P < 0.05). The respiratory rate decreased in all groups after injection, although this reduction was significant only in group I (P < 0.05). In conclusion, the combination of metamizole-propofol is safer and more compatible with the physiology of pigeons and can be used for short operations, especially when inhalation agents are contraindicated.
4

Intravenous midazolam as an induction agent for inhalation anaesthesia in dogs

84%
Cwiek A., Balicki I., Rozanska D.
Medycyna Weterynaryjna
|
2010
|
tom 66
|
nr 01
37-40
The aim of this study was to evaluate midazolam as an intravenous induction agent for inhalation anaesthesia in the routine castration of dogs. Investigations concerned the dose required for induction as well as its effects on the dog’s general condition, arterial blood gas and acid-base balance. A total of 24 male dogs of various breeds were studied, ranging in age from 1 to 11 years and in weight from 5 to 27 kg. Dogs were recruited at the Department and Clinics of Animal Surgery, University of Life Sciences in Lublin, Poland. The dogs were premedicated intramuscularly with xylazine and atropine sulphate at dose rates of 2 mg/kg and 0.05 mg/kg respectively. Twenty minutes after premedication, midazolam was administered by intravenous infusion. Intravenous midazolam proved useful as an induction agent for inhalation anaesthesia. The dose used was dependent on the animal’s reaction. The induction of anaesthesia with midazolam was successful and enabled endotracheal intubation and inhalation anaesthesia with a halothane-oxygen mixture. The application of midazolam with halothane, however, led to transitory disturbances in systemic acid-base balance due to gas exchange abnormalities. The median effective dose of midazolam for the induction of anaesthesia was 0.46 mg/kg i.v. Postoperatively, a full recovery of consciousness and motor functions was rapidly achieved in all dogs. Further studies on midazolam as an intravenous induction agent for inhalation anaesthesia in the dog are warranted.
5

Cardiopulmonary, biochemical, and haematological changes after detomidine-midazolam-ketamine anaesthesia in calves

84%
Kilic N.
Bulletin of the Veterinary Institute in Puławy
|
2008
|
tom 52
|
nr 3
The aim of the study was to investigate the suitability of detomidine-midazolam-ketamine combination for umbilical surgery in calves. Fifteen calves subjected to umbilical surgery received detomidine (100 pg/kg b.w.), midazolam (0.5 mg/kg b.w.), and ketamine (10 mg/kg b.w.) intravenously (iv), as a mixture of the drugs. Rectal temperature, and heart, pulse, and respiratory rate were recorded before drug administration and at 5, 10, 15, 30, and 45 min after anaesthesia. Haematological and biochemical parameters were detected before drug administration, 15, 30, 45, and 60 min after drug injection and 24 h after anaesthesia. The combination of the compounds resulted in anaesthesia lasting about 45 min and a satisfactory immobilisation for umbilical surgery, although some hypoxaemia and respiratory acidosis occurred. The body temperature of the calves decreased significantly (P<0.05) during the anaesthesia from 38.5°C to 37.9°C. Haemoglobin, PCV, and RBC decreased significantly (P<0.05) for a short time. The values for plasma glucose, creatinine, and ALT increased significantly (P<0.05). However, they returned to the baseline at 24 h. Muscle relaxation was good and no complications were encountered.
6

Znieczulenie zlozone z udzialem atropiny, midazolamu i propofolu w zabiegach artroskopowych u psow

67%
Chyczewski M., Jalynski M., Brzeski W., Nowicki M., Adamiak Z., Depta A., Rychlik A.
Medycyna Weterynaryjna
|
2002
|
tom 58
|
nr 02
120-123
7

Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits

67%
Rozanska D.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 2
209-216
An anesthetic combination of medetomidine-midazolam-atropine and propofol was investigated in twenty New Zealand White rabbits. Each rabbit received combined medetomidine at a dosage of 0.2 mg/kg (b.w.), midazolam (0.5 mg/kg b.w.) and atropine (0.5 mg/kg b.w.) intramuscularly for induction of anesthesia. Propofol was administered intravenously - given to effect, and after that by an infusion pump to maintain anesthesia. The influence of the anesthetic combination on the cardiopulmonary system was evaluated by monitoring respiratory and heart rates, blood pressure, and arterial blood gas tensions. The results obtained showed that propofol infusion at a rate of 0.5 mg/kg b.w./min maintained general anesthesia effectively with few side effects on the cardiopulmonary system during 30 minutes. However, slight hypotension, hypercapnia, and respiratory acidosis were associated with infusion of this anesthetic. The recovery of the rabbits from the anesthesia was smooth. Two rabbits died 20 to 24 hours after anesthesia. In conclusion, an anesthetic combination with medetomidine-midazolam-atropine and propofol at the investigated doses was shown to be a safe method to induce and maintain general anesthesia enabling short-term surgical procedures in healthy animals.
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