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1

Investigation on the relationship between lymphocyte subsets, immunoglobulin levels and adenosine deaminase activities in immunosuppressive dove methylprednisolone treated dogs

100%
Altug N., Agaoglu Z. T.
Bulletin of the Veterinary Institute in Puławy
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2007
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tom 51
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nr 1
Seven healthy dogs were administered with methylprednisolone orally (2 mg/kg body weight/d) at the beginning of the study (between 0-10 d), then the dosing was decreased at 10 d intervals throughout 10 to 60 d in an alternate-day therapy programme. Drug administration to the dogs was stopped on the 60 d. Total leukocyte count; polymorphonuclear leukocytes, and neutrophil ratios increased and eosinophil, mononuclear leukocytes, lymphocyte, and monocyte ratios were decrease when these values were compared to changes between days. Furthermore, in lymphocyte subsets, B lymphocytes and CD 8 T lymphocytes ratios were found to decrease. In addition, CD 3 T lymphocyte ratios decreased on the 61 d and CD 4 T lymphocyte ratios increased on the 21, 41, 51 and 61 d. IgM and IgG levels decreased between the days. Serum total ADA and ADA 1 activities decreased during the application, but ADA 2 activity did not change significantly. As a result, after immunosuppressive dose of methylprednisolone application, reduction in the ADA and ADA 1 activity can be used as determinant of the suppression of immune system components.
2
Content available remote

Effect of cannabinoid receptors 1 modulation on osteoporosis in a rat model of different ages

84%
Samir S. M., Malek H. A.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 5
3
Content available remote

The role of ANCA and anti-GBM antibodies in pulmonary-renal syndrom due to Wegener’s granulomatosis

67%
Zycinska K., Wardyn K. A., Zielonka T. M., Otto M.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
4

The effect of methylprednisolone on the dynamics of oxygen uptake and peroxidase and superoxide dismutase activities in skeletal muscles of mice infected with Trichinella spiralis larvae

67%
Wandurska-Nowak E., Boczon K., Derda M., Hadas E., Matias-Guzek A.
Acta Parasitologica
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1998
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tom 43
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nr 1
The present study was undertaken to examine whether treatment with methylprednisolone could normalise (modulate) the biochemical dysfunctions in the skeletal muscles of mice in experimental trichinellosis. Our studies included investigations of two indices of the uncoupling of oxidative phosphorylation: RCI value (respiratory control index) and QO₂ (oxygen uptake in state IV and in state III) as well as of two antioxidant enzyme activities: peroxidase (POX, E.C. 1.11.1.7) and superoxide dismutase (SOD, E.C. 1.15.1.1) in mouse muscles infected with Trichinella spiralis. Treatment with methylprednisolone was responsible for the normalisation of the activity of POX at 30 d.p.i. and was responsible for 50% decrease in stimulation of SOD activity at 43 d.p.i. At other points of measurement the drug showed no statistical influence on the activities of this enzymes. The drug had not statistically significant effect on the value of the respiratory control index and on the value of oxygen uptake.
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