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The aim of the present work was to evaluate the mercury content in hair of inhabitants of Wrocław, in southwestern Poland. On the basis of a questionnaire and analysis of hair by atomic absorption spectroscopy, it was possible to indicate the sources of mercury exposure. The mean mercury level in hair of the whole population (n=321) was 0.203±0.181 mg·kg⁻¹. The content of mercury in hair of subjects who consumed fish exceeded the upper limit of reference value, which was 0.397 mg·kg⁻¹. Subjects who declared consumption of fish, honey, and mouldy cheese, contained statistically more mercury: 60.5%, 35.4%, and 37.8%, respectively, than those who did not eat these types of food. It was noticed that there was no effect from the place of residence, the presence of pollution emitters, gender, age, weight, height, presence of amalgam fillings, hair dyeing, and smoking cigarettes on mercury content in hair.
Organic mercury (CH3HgCl) with metal concentration 5 ppm in tap water was applied to rats suckling their newborn for the first 21 days of life. A second group of young rats took the mercury in their tap water 5 ppm from the 22nd to the 43rd day of postnatal life. Control rats drank tap water only. In 2-month-old male rats the following behavioral study was performed after saline or specific central dopamine receptor agonists and agonists apply (quinpirole, SKF-38393, haloperidol, SCH-23390): irritability, yawning behavior, oral activity, locomotion, exploratory activity, and catalepsy. In the striatum and frontal cortex of three examined groups the biogenic amines levels (DA, DOPAC, HVA, 3-MT, 5-HT, 5-HIAA, NA) were estimated by means of HPLC/ED technique, and DA and 5-HT turnover. The effect of quinpirole (a central dopamine D2 receptor agonists) was also examined on (3H)glucose uptake in discrete parts of the brain. It was shown that mercury affected behavioral changes after dopaminergic agents apply to adult animals when exposed in the period from the 22nd to 43rd day of postnatal development. Biochemical changes (biogenic amines level, turnover and (3H)glucose uptake) were more pronounced in adult animals exposed to mercury via mother's milk (1st to 21st day of life). In light of the above we conclude that early postnatal exposure of rats to organic mercury modulates activity of the central dopamine neurotransmitter system.
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