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  1. 11 Folia Histochemica et Cytobiologica

  2. 5 Journal of Physiology and Pharmacology

  3. 2 Acta Biochimica Polonica

  4. 2 Folia Biologica

  5. 1 Journal of Physiology and Pharmacology. Supplement

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  1. 5 Mroczko B.

  2. 5 Szmitkowski M.

  3. 3 Groblewska M.

  4. 3 Gryko M.

  5. 3 Kedra B.

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  1. 1 2020

  2. 1 2018

  3. 1 2017

  4. 4 2016

  5. 2 2013

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1

In vitro reoxygenation following hypoxia increases MMP-2 and TIMP-2 secretion by human umbilical vein endothelial cells

100%
Cavdar Z., Oktay G., Egrilmez M. Y., Genc S., Genc K., Altun Z., Islekel H., Guner G.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 1
69-73
 Endothelial cells lining the inner blood vessel walls play a key role in the response to hypoxia, which is frequently encountered in clinical conditions such as myocardial infarction, renal ischemia and cerebral ischemia. In the present study we investigated the effects of hypoxia and hypoxia/reoxygenation on gelatinases (matrix metalloproteinase-2 and -9), their inhibitor (TIMP-2) and activator (MT1-MMP), in human umbilical vein endothelial (HUVE) cells. HUVE cells were subjected to 4 h of hypoxia or hypoxia followed by 4 and 24 h of reoxygenation. The pro- and active forms of MMP-2 and MMP-9 were analyzed by gelatin zymography; TIMP-2 protein level was assayed using ELISA, while MT1-MMP activity was measured using an activity assay. The secretion of MMP-2 proform increased significantly in cells subjected to 4h of hypoxia followed by 4 or 24 h of reoxygenation, compared with the normoxic group. TIMP-2 protein level also increased significantly in the hypoxia/reoxygenation groups, compared with the normoxic group. There were no statistically significant differences in the levels of active MT1-MMP in all groups. This study indicates that MMP-2 and TIMP-2 could be regarded as important components of a mechanism in the pathophysiology of ischemic injury following reperfusion.
2
Content available remote

Spatial differences of matrix metalloproteinase-2 and matrix metalloproteinase-9 within abdominal aortic aneurysm wall and intraluminal thrombus

100%
Siennicka A., Zuchowski M., Kaczmarczyk M., Cnotliwy M., Clark J. S., Jastrzebska M.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 6
3

Differential glomerular immunoexpression of matrix metalloproteinases MMP-2 and MMP-9 in idiopathic IgA nephropathy and Schoenlein-Henoch nephritis

84%
Danilewicz M., Wagrowska-Danilewicz M.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 1
63-67
4

Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients

84%
Groblewska M., Mroczko B., Kozlowski M., Niklinski J., Laudanski J., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 4
5
Content available remote

The assessment of serum and diagnostic peritoneal lavage concentration of matrix metalloproteinase-2, matrix metalloproteinase-9, carbohydrate antigen 19-9, and carcinoembryonic antigen in patients with pancreatic cancer and chronic pancreatitis

84%
Dranka-Bojarowska D., Lewinski A., Lekstan A., Gajda M., Ciosek J., Mrowiec S.
Journal of Physiology and Pharmacology
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2020
|
tom 71
|
nr 5
6

Expression of matrix metalloproteinase-2 mRNA in the chicken ovary in relation to follicle remodelling

84%
Lesniak A., Hrabia A.
Folia Biologica
|
2012
|
tom 60
|
nr 3-4
7

In vitro effects of TCDD, PCB126 and PCB153 on estrogen receptors, caspases and metalloproteinase-2 mRNA expression in the chicken shell gland

84%
Hrabia A., Lesniak A., Sechman A.
Folia Biologica
|
2013
|
tom 61
|
nr 3-4
8
Content available remote

Effects of renin-angiotensin system inhibitors on fibrosis in patients with alcoholic chronic pancreatitis

84%
Madro A., Kurzepa J., Celinski K., Slomka M., Czechowska G., Kurzepa J., Kazmierak W., Buszewicz G., Ciesielka M., Madro R.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 1
9

Matrix metalloproteinase-2 C-1306T promoter polymorphism and breast cancer risk in the Saudi population

84%
Saeed H. M., Alanazi M. S., Alshahrani O., Parine N. R., Alabdulkarim H. A., Shalaby M. A.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 3
Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with susceptibility to breast cancer in the Saudi population. Ninety breast cancer patients and 92 age matched controls were included in this study. TaqMan Allele Discrimination assay and DNA sequencing techniques were used for genotyping. The results showed that, the frequency of MMP-2 CC wild genotype was lower in breast cancer patients when compared with healthy controls (0.65 versus 0.79). The homozygous CC (OR=2, χ2=5.36, p=0.02) and heterozygous CT (OR=1.98, χ2=4.1, p=0.04) showing significantly high risk of breast cancer in the investigated group. In conclusion our data suggest that the MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population.
10

Matrix metalloproteinases-2, -7 and tissue metalloproteinase inhibitor-1 expression in human endometrium

84%
Grzechocinska B., Dąbrowski F. A., Cyganek A., Chlebus M., Kobierzycki C., Michalowski L., Gornicka B., Wielgos M.
Folia Histochemica et Cytobiologica
|
2018
|
tom 56
|
nr 3
11

Potentially positive ageing-related variations of medial smooth muscle cells in the saphenous veins used as aortocoronary bypass grafts

84%
Perek B., Malinska A., Gasowski J., Ostalska-Nowicka D., Perek A., Jemielity M., Zabel M., Nowicki M.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 2
12
Content available remote

Expression of superoxide dismutase and matrix metalloproteinase type 2 in diaphragm muscles of young rats

67%
Carmeli E., Maor M., Kodesh E.
Journal of Physiology and Pharmacology. Supplement
|
2009
|
tom 60
|
nr 5
13
Content available remote

Concentrations and activities of metalloproteinases 2 and 9 and their inhibitors (TIMPS) in chronic pancreatitis and pancreatic adenocarcinoma

67%
Lekstan A., Lampe P., Lewin-Kowalik J., Olakowski M., Jablonska B., Labuzek K., Jedrzejowska-Szypulka H., Olakowska E., Gorka D., Filip I., Dranka-Bojarowska D.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 6
14

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes

67%
Puskulluoglu M., Lukasiewicz E., Miekus K., Jarocha D., Majka M.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 4
15
Content available remote

Melatonin, advanced oxidation protein products and total antioxidant capacity as seminal parameters of prooxidant-antioxidant balance and their connection with expression of metalloproteinases in context of male fertility

67%
Kratz E. M., Piwowar A.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 5
16

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

67%
Groblewska M., Mroczko B., Gryko M., Kedra B., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 4
17

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer

67%
Groblewska M., Siewko M., Mroczko B., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 1
18

No correlation between pinopode formation and LIF and MMP2 expression in endometrium during implantation window

67%
Mikolajczyk M., Skrzypczak J., Wirstlein P.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 4
19

Influence of IGF1, TGFbeta1, bFGF and G-CSF/M-CSF on the mRNA levels of selected matrix proteins, cytokines, metalloproteinase 3 and TIMP1 in rat synovial membrane cells

67%
Osiecka-Iwan A., Moskalewski S., Hyc A.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 3
20

Expression of matrix metalloproteinase-9 in the neoplastic and interstitial inflammatory infiltrate cells in gastric cancer

67%
Mroczko B., Lukaszewicz-Zajac M., Guzinska-Ustymowicz K., Gryko M., Czyzewska J., Kemona A., Kedra B., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 3
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