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  1. 10 Folia Histochemica et Cytobiologica

  2. 4 Archivum Immunologiae et Therapiae Experimentalis

  3. 3 Acta Biochimica Polonica

  4. 3 Cellular and Molecular Biology Letters

  5. 3 Journal of Physiology and Pharmacology. Supplement

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  1. 2 Agrawal A. K.

  2. 2 Grzebieniak Z.

  3. 2 Jelen M.

  4. 2 Kobierzycki C.

  5. 2 Rudnicki J.

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  1. 3 2019

  2. 2 2015

  3. 3 2011

  4. 4 2010

  5. 4 2009

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1
Content available remote

Regulation of gastrointestinal mucosal growth during aging

100%
Majumdar A. P. N.
Journal of Physiology and Pharmacology. Supplement
|
2003
|
tom 54
|
nr 4
143-154
The increase in the aging population has led to a growing interest in achieving a better understanding of the aging process and of diseases that are predominantly expressed during advancing age. Since the structural and, in turn, the functional integrity of the mucosa of the gastrointestinal tract (GI) are maintained by constant renewal of cells, a detailed knowledge of the events that initiate and regulate mucosal proliferative processes is essential for a better understanding of the normal aging process as well as age-associated dysfunctions, including malignancy that represent disorders of tissue growth. In Fischer-344 rats, aging is associated with increased mucosal proliferative activity in much of the GI tract. On the other hand, the functional properties are either decreased or remain unchanged during advancing age. Basal gastric acid and pepsin output decline during aging, as is gastrin secretion. In contrast, antral gastrin levels increase during this period, as is mucosal histidine decarboxylase activity. The age-related decline in gastrin secretion could partly be attributed to a higher ratio of somatostatin (D) to gastrin (G) cells in the antral mucosa. The age-related rise in GI mucosal proliferative activity could not be attributed to the trophic action of either gastrin or bombesin, since they caused no significant change in mucosal proliferation in aged rats. On the other hand, EGF and TGF-alphalpha appear to be involved in regulating mucosal proliferation during aging. Aging is associated with increased activation of EGF-receptor (EGFR), the common receptor for EGF and TGF-alpha. This could be due to (a) increased levels of membrane-bound precursor form(s) of TGF-alpha resulting in increased activation EGFR signaling processes through an autocrine/paracrine mechanism, (b) heightened sensitivity of mucosal EGFR to EGF and TGF-alpha such that comparatively lower levels of these peptides are required to activate EGFR in aged than in young animals and/or (c) loss of EGFR regulatory factor(s) such as ERRP (EGFR Related Protein), a "negative regulator" of EGFR.
2

Molecular phylodiagnosis of Enterocytozoon bieneusi and Encephalitozoon intestinalis in children with cancer: microsporidia in malignancies as an emerging opportunistic infection

100%
Ghoyounchi R., Mahami-Oskouei M., Rezamand A., Spotin A., Aminisani N., Nami S., Pirestani M., Barahmat R., Madadi S.
Acta Parasitologica
|
2019
|
tom 64
|
nr 1
3

The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type

100%
Agrawal A. K., Jelen M., Rudnicki J., Grzebieniak Z., Zysko D., Kielan W., Slonina J., Marek G.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 1
26-29
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Breast self-examination as a method for early detection of breast cancer based on literature review

100%
Marszalek A., Walaszek R.
Health Problems of Civilization
|
2015
|
tom 09
|
nr 4
5

Physical state of human papillomavirus type 16 in cervical cell DNA

100%
Szostek S., Klimek M., Zawilinska B., Kosz-Vnenchak M.
Folia Biologica
|
2008
|
tom 56
|
nr 3-4
269-271
6

Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia [B-CLL]

100%
Giannopoulos K., Dmoszynska A., Bojarska-Junak A., Schmitt M., Rolinski J.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 4
457-460
7

Is the lung cancer among the hereditary malignancies?

100%
Krawczyk P., Michnar M., Kieszko R., Krol A., Wojcik M., Chocholska S., Milanowski J.
Bulletin of the Veterinary Institute in Puławy. Supplement
|
2002
8

NBL 1 and anillin [ANLN] genes over-expression in pancreatic carcinoma

84%
Olakowski M., Tyszkiewicz T., Jarzab M., Krol R., Oczko-Wojciechowska M., Kowalska M., Kowal M., Gala G. M., Kajor M., Lange D., Chmielnik E., Gubala E., Lampe P., Jarzab B.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 2
249-255
9

Histopathological case report of high grade salivary duct carcinoma

84%
Borevec J., Cegan M., Mala K., Harmash N., Chramosta P., Kobierzycki C., Bobek V.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 4
10

Signifcance and role of pattern recognition receptors in malignancy

84%
Zeromski J., Kaczmarek M., Boruczkowski M., Kierepa A., Kowala-Piaskowska A., Mozer-Lisewska I.
Archivum Immunologiae et Therapiae Experimentalis
|
2019
|
tom 67
|
nr 3
11

The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A [LMP2A] in latency and cancer

84%
Pang M. F., Lin K.-W., Peh S.-C.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 2
222-247
Epstein-Barr virus (EBV) is a ubiquitous virus with infections commonly resulting in a latency carrier state. Although the exact role of EBV in cancer pathogenesis remains not entirely clear, it is highly probable that it causes several lymphoid and epithelial malignancies, such as Hodgkin’s lymphoma, NK-T cell lymphoma, Burkitt’s lymphoma, and nasopharyngeal carcinoma. EBV-associated malignancies are associated with a latent form of infection, and several of these EBV-encoded latent proteins are known to mediate cellular transformation. These include six nuclear antigens and three latent membrane proteins. Studies have shown that EBV displays distinct patterns of viral latent gene expression in these lymphoid and epithelial tumors. The constant expression of latent membrane protein 2A (LMP2A) at the RNA level in both primary and metastatic tumors suggests that this protein might be a driving factor in the tumorigenesis of EBV-associated malignancies. LMP2A may cooperate with the aberrant host genome, and thereby contribute to malignant transformation by intervening in signaling pathways at multiple points, especially in the cell cycle and apoptotic pathway. This review summarizes the role of EBV-encoded LMP2A in EBV-associated viral latency and cancers. We will focus our discussions on the molecular interactions of each of the conserved motifs in LMP2A, and their involvement in various signaling pathways, namely the B-cell receptor blockade mechanism, the ubiquitin-mediated (Notch and Wnt) pathways, and the MAPK, PI3-K/Akt, NK-κB and STAT pathways, which can provide us with important insights into the roles of LMP2A in the EBV-associated latency state and various malignancies.
12

Molecular markers [c-erbB-2, p53] in breast cancer

84%
Agrawal A. K., Jelen M., Rudnicki J., Grzebieniak Z., Zukrowski P., Nienartowicz E.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 4
449-455
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Joint effect of N-acetyltransferase 2 gene and smoking status on bladder carcinogenesis in Algerian population

84%
Ribouh-Arras A., Chaoui-Kherouatou N., Hireche A., Abadi N., Satta D.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2019
|
tom 100
|
nr 2
14

Is p53 intronic variant G13964C associated with predisposition to cancer

84%
Fiszer-Maliszewska L., Kazanowska B., Kusnierczyk P., Manczak M., Niepieklo W., Pochron-Zeman B., Nowakowska B.
Journal of Applied Genetics
|
2003
|
tom 44
|
nr 4
15

Reactivity of monoclonal antibodies OK-CLL [anti-CD5] with peripheral blood cells of patients with B cell lymphoproliferative disorders

84%
Milosevic D., Marinkovic M., Jelic S., Colovic M., Spuzic I.
Archivum Immunologiae et Therapiae Experimentalis
|
1995
|
tom 43
|
nr 1
16

Molecular basis of inherited predispositions for tumors

84%
Lubinski J., Gorski B., Kurzawski G., Jakubowska A., Cybulski C., Suchy J., Debniak T., Grabowska E., Lener M., Nej K.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 3
On the basis of literature data and own experience the authors review the current knowledge about the molecular basis of inherited predispositions for tumors. They hypothesize that in the near perspective 5-10 years studies using existing registry data/material and the latest novel technology will allow the identification of the molec­ular background for the majority of hereditary cancers which will have enormous practical consequences especially for the prevention of malignancies.
17

Extrathymic pathways of T cell differentiation

84%
Abo T.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
tom 49
|
nr 2
18

Comparative studies of nuclear DNA content in benign and malignant thyroid lesions

84%
Konarska L., Skierski J., Ellert A., Steinbrich J., Wozniak A., Kalczak M.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 3
Currently available data suggest that DNA aneuploidy is associated with aggressive behavior of and unfavorable prognosis in several malignant human tumors as com­pared with diploid malignancies. However, the diagnostic and prognostic importance of flow cytometric DNA measurements in the case of thyroid neoplasms remains con­troversial. Therefore, the aim of our study was to evaluate utility of DNA index (DI) and proliferative index (PI) in distinguishing benign from malignant thyroid lesions taking into account the possible influence of intra-tumor heterogeneity and tissue preparation mode on DNA flow-cytometry measurements. A retrospective study was performed on 71 paraffin-embedded specimens from 57 patients with benign and malignant thyroid pathologies: 13 colloid goitres, 12 parenchymatous goitres, 19 adenomas and 13 carcinomas. In 14 of 57 cases two sepa­rate specimens taken from different areas of the same lesion were analysed and DNA parameters were compared. Additionally, flow cytometry DNA analysis was parallelly performed on 3 adjacent but differently processed tissue sections (fresh, forma­lin-fixed and paraffin-embedded) taken from each of 26 surgically excised thyroid le­sions. DNA content was also analysed in both fresh and formalin-fixed twin specimens of normal pig thyroid glands (N = 6). We demonstrated that all tumors diagnosed as thyroid carcinomas were associated with abnormal nuclear DNA content although aneuploidy was not found specific to malignant thyroid tumors. Aneuploid samples of benign thyroid lesions exhibited higher proliferative activity, expressed as mean PI values, than diploid ones. In carci­nomas the mean PI values were significantly higher than in benign lesions, independ­ently whether they concerned aneuploid or diploid tissues. Considering intra-tumor heterogeneity, the flow cytometric DNA parameters can be assumed as reproducible despite differences in the mode of tissue fixation and preparation for analysis.
19

Connexin 43 recruits E-cadherin expression and inhibits the malignant behaviour of lung cancer cells

67%
Xu H.-T., Li Q.-C., Zhang Y.-X., Zhao Y., Liu Y., Yang Z.-Q., Wang E.-H.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 3
315-321
20

Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers

67%
Wojnar A., Kobierzycki C., Krolicka A., Pula B., Podhorska-Okolow M., Dziegiel P.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 3
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