Wyniki wyszukiwania

1

Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation

100%

Wasik M., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 1-2

2

Ecto-5'-nucleotidase activity and CD73 expression in patients at different stages of the B-cell chronic lymphocytic leukemia

86%

Rosi F., Marotta G., Raspadori D., Bellisai B., Marinello E., Carlucci F., Tabucchi A.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

3

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Relationship between DNA replication and DNA repair in human lymphocytes proliferating in vitro in the presence and in absence of mutagen

86%

Szyfter K., Wiktorowicz K., Wielgosz M. S., Zajaczek S., Kujawski M., Jaloszynski P., Czub M., Markowska J.

Journal of Applied Genetics

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1995

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tom 36

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nr 4

The effects of mutagens on DNA replication and DNA repair were studied in peripheral blood lymphocytes (PBL) obtained from 21 healthy subjects, 2 samples from healthy heterozygote of Xeroderma pigmentosum (XP) and 2 samples from patient with clinically recognised XP. Inter-individual variations were found in DNA replication and in the level of spontaneous DNA repair measured under standard culture condition. Exposure of human PBL proliferating in vitro to B(a)P was followed by a partial inhibition of replicative DNA synthesis in all subjects and by an induction of DNA repair in healthy subjects. In XP patients DNA repair synthesis remained at the level attributed to spontaneous DNA repair. The response to mutagen varied individually. Results were analysed statistically. It was established that the studied indices of DNA synthesis correlate well with each other. The highest correlation was found between the levels of spontaneous and B(a)P-induced DNA repair. It is concluded that the level of spontaneous DNA repair is predictive for an estimation of cells ability to repair DNA damage. Inter-individual variations in the inhibition of DNA replication and in DNA repair synthesis are also dependent on the type of mutagen as shown by effects of other mutagens. Different effects of mutagen exposure on the inhibition of DNA replicative synthesis and induction of DNA repair can be explained by genetically controlled differences in the activity of enzymes responsible for mutagen processing and lesion removal.

4

Treatment of Graves’ disease with methimazole in children alters the proliferation of Treg cells and CD3+ T lymphocytes

72%

Klatka M., Kaszubowska L., Grywalska E., Wasiak M., Szewczyk L., Foerster J., Cyman M., Rolinski J.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 1

5

Cell-mediated immunity in yellow forms in rainbow trout

72%

Siwicki A., Dobosz S., Goryczko K., Kuzminski H., Kohlmann K., Trapkowska S., Kazun B.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 3 Suppl.

6

The regulating function of heterotrimeric G proteins in the immune system

72%

Wang Y., Li Y., Shi G.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 4

7

Usefulness of neutral red uptake method for investigation of the bovine leukocyte viability and lymphocyte proliferation

72%

Fijalkowski K., Nawrotek P., Czernomysy-Furowicz D.

Advances in Agricultural Sciences

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2011

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tom 14

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nr 1-2

8

Clinical and In vitro studies on impact of high-dose etoposide pharmacokinetics prior allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia on the risk of post-transplant leukemia relapse

72%

Sobiak J., Kazimierczak U., Kowalczyk D. W., Chrzanowska M., Styczynski J., Wysocki M., Szpecht D., Wachowiak J.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 5

9

Helicobacter pylori lipopolysaccharide activity in human peripheral blood mononuclear leukocyte cultures

58%

Grebowska A., Moran A. P., Bielanski W., Matusiak A., Rechcinski T., Rudnicka K., Baranowska A., Rudnicka W., Chmiela M.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 4

437-442

Helicobacter pylori (H. pylori) have been recognized as a major cause of chronic gastritis, gastric and duodenal ulcers and gastric cancer. Macrophages are the targets of lipopolysaccharide (LPS), which is a constituent of the outer membrane of Gram-negative rods. In this study we focused on a potential role of macrophages in the proliferation of human peripheral blood mononuclear leukocytes (PBML) in the milieu of H. pylori LPS and standard E. coli LPS. First, we found that H. pylori and E. coli LPS induced proliferation of total PBML (tPBML) from 5 out 21 healthy blood donors (LPS responders). In the LPS milieu, tPBML from the majority of volunteers (LPS non-responders) showed a significant decrease in the [3H]-thymidine incorporation as compared to tPBML in medium alone. The decreased cell proliferation was associated with a diminished metabolic activity of non-adherent lymphocytes. Then, non-adherent lymphocytes were stimulated with autologous macrophages pulsed with bacterial LPS. Still, the lymphocytes from the non-responders did not proliferate in the cultures with LPS exposed macrophages. In the group of LPS responders, the macrophages pulsed with H. pylori LPS significantly reduced the proliferation of non-adherent lymphocytes. The possible mechanism regulating the responses of PBML to bacterial LPS with an implication for the outcome of H. pylori infections is discussed.

10

The antimutagenic activity of two plant - derived compounds. A comparative cytogenetic study

58%

Gasiorowski K., Brokos B., Kozubek A., Oszmianski J.

Cellular and Molecular Biology Letters

|

2000

|

tom 05

|

nr 2

The antimutagenic activity of alkylresorcinols from cereal grains and anthocyanins from Aronia melanocarpa fruit were compared in three short-term mphocyte tests: a sister chromatid exchange test, a cytokinesis-blocked micronucleus assay and a thioguanine-resistance test. It was noticed that both tested compounds significantly decreased the rate and frequency of mutations induced in cultured lymphocytes with two standard mtagens: benzo[a]pyrene and mitomycin C. Alkylresorcinols appeared to be acre potent antimutagenic compounds than anthocyanins. Anthocyanins exhibited a stronger inhibitory effect on the generation and release of free radicals by human granulocytes in vitro, as measured with the NBT-reduction test. The results suggest that alkylresorcinols and anthocyanins exerted an antimutagenic influence through multifarious mechanisms, one of which could be a limitation of free radical involvement in mutagenesis.

11

Met-enkephalin modulates dexamethasone-induced leucocyte suppression in sheep

58%

Pierzchala-Koziec K., Zubel J., Kepys B.

Acta Biologica Cracoviensia. Series Zoologia

|

2001

|

tom 43

12

Polysaccharides from Laetiporus sulphureus [Basidiomycetes] II. Evaluation of immunostimulative and antitumour activity

58%

Gasiorowski K., Brokos B., Lamer-Zarawska E., Trocha-Grimshaw J.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

1993

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tom 41

|

nr 4

13

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

58%

Pronin A. V., Nikolaeva T. N., Deyeva A. V., Zaytseva L. G., Vasil'eva E.I., Kirillicheva G. B., Baturina I. G., Solov'eva M.S., Zakharov V. M.

Acta Theriologica. Supplement

|

1997

|

nr 04

An immune system status of socially stressed laboratory rats Rattus norvegicus Berkenhout, 1769 and their offsprings was studied. Several tests on activity of the macrophages and lymphocytes as well as on the tumour necrosis factor a (TNFa) activity in the blood serum were used to assess an immune system status of the stressed and control groups of rats. The results indicated that social stress led to obvious alterations in the immune system of the stressed rats and especially of their offspring, where the changes were more pronounced.

Ograniczanie wyników

Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation

Ecto-5'-nucleotidase activity and CD73 expression in patients at different stages of the B-cell chronic lymphocytic leukemia

Relationship between DNA replication and DNA repair in human lymphocytes proliferating in vitro in the presence and in absence of mutagen

Treatment of Graves’ disease with methimazole in children alters the proliferation of Treg cells and CD3+ T lymphocytes

Cell-mediated immunity in yellow forms in rainbow trout

The regulating function of heterotrimeric G proteins in the immune system

Usefulness of neutral red uptake method for investigation of the bovine leukocyte viability and lymphocyte proliferation

Clinical and In vitro studies on impact of high-dose etoposide pharmacokinetics prior allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia on the risk of post-transplant leukemia relapse

Helicobacter pylori lipopolysaccharide activity in human peripheral blood mononuclear leukocyte cultures

The antimutagenic activity of two plant - derived compounds. A comparative cytogenetic study

Met-enkephalin modulates dexamethasone-induced leucocyte suppression in sheep

Polysaccharides from Laetiporus sulphureus [Basidiomycetes] II. Evaluation of immunostimulative and antitumour activity

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring