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1

Polyovulation in cattle following ultrasound-guided follicle puncture and stimulation with very low doses of eCG

100%
Max A.
Polish Journal of Veterinary Sciences
|
2001
|
tom 04
|
nr 1
2

Influence of low doses of deoxynivalenol applied per os on chosen indexes of immune response in swine

100%
Zielonka L., Gajecki M., Obremski K., Zwierzchowski W.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 3 Suppl.
3

Effect of bioactivated sodium azide on the hatchability indices in hens

100%
Grolmus J., Trebaticka M.
Animal Science Papers and Reports. Supplement
|
2004
|
tom 22
|
nr 2
4

The activity of various enzymes in the homogenates of the human breast cancer after treatment of the low doses of mitomycin C and epirubicin

84%
Rzymowska J., Dyrde Z.
Applied Biology Communications. Lublin Scientific Center
|
1991
|
tom 01
|
nr 6
5

A low dose of chlorfenvinphos affects hepatic enzymes in serum and antioxidant enzymes in erythrocytes and liver of rats

84%
Lukaszewicz-Hussain A., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2005
|
tom 14
|
nr 2
The aim of this study was to investigate the effect of chlorfenvinphos administered at a single dose of 0.02 LD50 on the activity of serum of liver damage indicatory enzymes, such as β-glucoronidase (BGR), acid phosphatase (AcP) and alanine and aspartate aminotransferases (ALT and AST), as well as on the activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and liver. The animals were divided into two groups: the control group, which received oil, and the experimental groups, which received oil solution of chlorfenvinphos at a dose of 0.02 LD50. After 1, 24 and 48 hours of intoxication with chlorfenvinphos the blood samples were collected and livers were quickly removed. This study indicates that acute intoxication with chlorfenvinphos administered at a dose of 0.02 LD50 leads to liver function disturbances, which is a likely result of increased generation of reactive oxygen species.
6
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Expression of cellular isoform of prion protein on the surface of peripheral blood lymphocytes among women exposed to low doses of ionizing radiation

84%
Klucinski P., Mazur B., Hrycek A., Masluch E., Cieslik P., Kaufman J., Martirosian G.
Annals of Agricultural and Environmental Medicine
|
2007
|
tom 14
|
nr 2
Ionizing radiation affects the expression of adhesive and co-stimulatory molecules in lymphocytes. The physiological function of cellular isoform of prion protein (PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc expression on their surface; however, no direct effect of radiation on PrPc level in these cells was investigated. The objective of this study was to determinate the effect of low doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes in the women operating X-ray equipment. In 36 female workers and 30 persons of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8 (T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with PrPc on their surface, were tested. Subgroups with respect to age and length of employment were selected. A signifi cant increase was observed in PrPc expression on CD3 and CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers compared to control. The PrPc level did not show signifi cant changes in subgroups in relation to age (below and over 40 years old) both in the investigated and control groups, whereas a lower percentage of PrPc expressing CD19 cells showed in employed women below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup with less than 10 years of employment.
7
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Comparative study on the efficiency of peracetic acid and chlorine dioxide at low doses in the disinfection of urban wastewaters

84%
De L. G., Sacchetti R., Zanetti F., Leoni E.
Annals of Agricultural and Environmental Medicine
|
2008
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tom 15
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nr 2
8

Effects of low doses of gamma rays on the stability of normal and diabetic erythrocytes

67%
Kaczmarska M., Kopyscianska Z., Fornal M., Grodzicki T., Matlak K., Korecki J., Burda K.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
We studied the influence of low doses of γ radiation (from 0.04 to 1.8 mGy) on the stability of human red blood cells (RBC) from healthy donors and diabetic patients using absorption spectroscopy. Because of the alteration of many enzymatic pathways in diabetic RBCs resulting in strong modification of the lipid and protein membrane components one could expect that the ionizing γ-radiation should influence the stability of the healthy and diabetic cells in a different way. Indeed, distinct discontinuities and monotonic changes of hemolysis detected in the healthy and diabetic RBCs suggest that various enzymatic and chemical processes are activated in these membranes by γ radiation. Mössbauer measurements showed that only the highest applied dose of γ radiation caused modification of hemoglobin in both types of RBCs.
9

Influence of low doses of deoxynivalenol on histopathology of selected organs of pigs

67%
Zielonka L., Wisniewska M., Gajecka M., Obremski K., Gajecki M.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 1
Deoxynivalenol is one of mycotoxins that are most frequently determined in animal feed manufactured in Poland. The examination of histopathological lesions concomitant with deoxynivalenol intoxication is difficult because of the common, often synergistic, reaction of this mycotoxin with other toxins, such as zearalenone or ochratoxin A, which has a strong nephrotoxic activity. The possibility of estimating histopathological lesions in the course of intoxication with pure toxin at various doses is therefore of interest. Dosages used in this experiment relate to clinical cases observed in feeding the animals with whole ration feed obtained by processing feedingstuffs contaminated with Fusarium moulds. However, concerning the fact of one-shot administration of clinically pure toxin, the main question was if it was a sufficient dose to cause changes in the histopathological picture of gastrointestinal tract organs. The experiment was carried out on 12 nursery pigs of mixed breed (Polish White Large x Polish White Ear-pendent) with an average body weigh of 35 kg. The experimental nursery pigs were divided into 3 groups: group I (n=4) – control; group II (n=4) – DON administered at a dose of 0.2 mg/kg b.w.; group III (n=4) – DON administered at a dose of 0.4 mg/kg b.w. After slaughter of the animals, macroscopic examination was performed and segments of duodenum, jejunum, ileum, liver and mesenteric lymph nodes were sampled and assigned for histopathological examination. The results obtained equate to the clinically observed signs in swine production involving some nutrient metabolism disturbances in the gastrointestinal tract in the course of deoxynivalenol mycotoxicosis. Histopathological examination of segments of the duodenum, the jejunum, the ileum, the liver and the lymph nodes indicate that the regressive lesions are more expressed in the experimental group treated with the highest concentration of deoxynivalenol.
10
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Administration of low doses of tumor necrosis factor-alpha protects rat liver from ischaemic damage and reperfusion injury

67%
Helewski K. J., Kowalczyk-Ziomek G. I., Czecior E., Swietochowska E., Wielkoszynski T., Czuba Z. P., Szliszka E., Krol W.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 3
273-278
Liver ischaemia and reperfusion (IR) injury is a significant clinical problem. The aim of our study was to investigate the protective effect of tumor necrosis factor-alpha (TNF-) on rat liver ischaemia-reperfusion injury. A TNF- dose of 3 µg/kg body weight was injected into rats that had undergone partial (70%) ischaemia and reperfusion. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total blood antioxidant level (using the FRAP test), and the concentrations of TNF-, myeloperoxidase (MPO) and malondialdehyde (MDA) in liver homogenates after 1, 6, and 72 hours of reperfusion were measured. It was demonstrated that, rats subjected to IR, the administration of small doses of TNF- significantly reduced ALT and AST activities after 60- minute liver ischaemia and 1 or 6 hour of reperfusion. The strongest reductions in ALT and AST activities were seen after 1 hour of reperfusion (30% and 35%, respectively). Exogenous TNF- reduced the release of this cytokine in all observed periods, with the greatest reduction observed after 1 hour of reperfusion. Decreases in MPO concentration (by 40-45% in all periods of observation), as a marker of hepatic neutrophil infiltration, and in MDA concentration, the end-product of lipid peroxidation (by 55-60% at all time points), accompanied the reduction of TNF- release. The administration of TNF- to the rats after IR did not alter total plasma antioxidant potential, as assayed by the FRAP test, after 1 hour of reperfusion; however, at the later times a marked increase (~ 40-50%) occurred. We demonstrated that intraperitoneal injections of small doses of TNF- protect rat livers from IR injury. The mechanism of this protection is related to reductions in the release of TNF- during IR after injection of this cytokine, resulting in reductions in oxidative stress and inflammation during the later phase of reperfusion.
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