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Long-term ascorbic acid administration causes anticonvulsant activity during moderate and long-duration swimming exercise in experimental epilepsy

100%

Tutkun E., Arslan G., Soslu R., Ayyildiz M., Agar E.

Acta Neurobiologiae Experimentalis

2015

tom 75

nr 2

The benefits of regular exercise on brain health are undeniable. Long-term exercise increases the production of reactive oxygen species in brain. Therefore, athletes often consume antioxidant supplements to remedy exercise-related damage and fatigue during exercise. The aim of this study is to evaluate the role of ascorbic acid in the effects of different intensities of swimming exercise on the brain susceptibility to experimental epilepsy in rats. Ascorbic acid was administered intraperitoneally (ip) during three different swimming exercise programme for 90 days (15 min, 30 min, 90 min/day). The anticonvulsant activity regarding the frequency of epileptiform activity appeared in the 80 min after 500 units intracortical penicillin injection in 30 min and 90 min/day exercise groups. The administration of ascorbic acid (100 mg/kg, ip) did not alter the anticonvulsant properties seen in the in short-duration (15 min/day) swimming exercise group. The amplitude of epileptiform activity also became significant in the 110 and 120 min after penicillin injection in the moderate (30 min/day) and long duration (60 min/day) groups, respectively. The results of the present study provide electrophysiologic evidence that long-term administration of ascorbic acid causes anticonvulsant activities in the moderate and long-duration swimming exercise. Antioxidant supplementation such as ascorbic acid might be suggested for moderate and long-duration swimming exercise in epilepsy.

Effect of experimental long-term exposure to low-dose zearalenone mycotoxicosis on selected morphometric parameters of the reproductive tract in sexually-immature gilts

100%

Jakimiuk E., Rybarczyk L., Zwierzchowski W., Obremski K., Gajecka M., Zielonka L., Gajecki M.

Bulletin of the Veterinary Institute in Puławy

2010

tom 54

nr 1

25-28

The objective of this study was to determine the effect of long-term (48 d), per os animal administration of low zearalenone (ZEA) doses (50% and 100% NOAEL values) on the dynamics of changes in the morphometric parameters of the reproductive organs in sexually-immature gilts. The experiment involved 12 clinically-healthy gilts aged 2 months with initial body weight of ± 40 kg and a determined immune status. The animals were randomly divided into two experimental groups (El, n=4; E2, n=4) and a control group (C, n=4). Group El was administered per os 20 µg of ZEA/kg b.w. for 48 d, group E2 received per os 40 µg of ZEA/kg b.w. for 48 d, and group C was administered per os placebo for 48 d. The mycotoxin was administered daily per os animal in gelatin capsules before morning feeding. The animals were slaughtered at the end of the experiment. No significant morphometric changes were noted in the reproductive system of the gilts, except for an increase in the number of medium-sized ovarian follicles in group El. This suggests that ZEA at low concentrations may cause hormonal effects (hyperoestrogenism) but it does not exhibit xenobiotic activity.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Bulletin of the Veterinary Institute in Puławy

1 Agar E.

1 Arslan G.

1 Ayyildiz M.

1 Gajecka M.

1 Gajecki M.

1 Jakimiuk E.

1 Obremski K.

1 Rybarczyk L.

1 Soslu R.

1 Tutkun E.

1 Zielonka L.

1 Zwierzchowski W.

1 2015

1 2010

Wyniki wyszukiwania

Long-term ascorbic acid administration causes anticonvulsant activity during moderate and long-duration swimming exercise in experimental epilepsy

Effect of experimental long-term exposure to low-dose zearalenone mycotoxicosis on selected morphometric parameters of the reproductive tract in sexually-immature gilts