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1

Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid

100%
Kodaira Y., Kusumoto T., Takahashi T., Matsumura Y., Miyagi Y., Okamoto K., Shidoji Y., Sagami H.
Acta Biochimica Polonica
|
2007
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tom 54
|
nr 4
777-782
Geranylgeranoic acid (GGA) and 2,3-dihydrogeranylgeranoic acid (2,3-diGGA) are geranylgerani-ol-derived metabolites (Kodaira et al.(2002) J Biochem132:327–334). In the present study, we examined the effects of these acids on HL-60 cells. The cells were differentiated into neutrophils by GGA stimulation like retinoic acid stimulation. In the case of cells stimulated with 2,3-diGGA, neutrophils were not detected, but the formation of lipid droplets was induced. On the other hand, when the cells were cultured in the presence of 0.1% FBS instead of 10% FBS, apoptotic cells were induced not only by GGA stimulation but also with 2,3-diGGA. In the latter case, when the cells were cultured in the co-presence of a caspase-3 inhibitor (Ac-DMQD-CHO), the lipid droplets formation was observed in the cells. These results suggest that GGA and 2,3-diGGA are extremely different from each other with respect to their effects on HL-60 cells.
2

Staining with ANS fluorescent dye reveals distribution of mitochondria and lipid droplet in cultured Leydig cell

100%
Bilinska B.
Folia Histochemica et Cytobiologica
|
1994
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tom 32
|
nr 1
3

Seasonal and photoperiodic effects on lipid droplet size and lipid peroxidation in the brown adipose tissue of bank voles (Myodes glareolus)

84%
Bonda-Ostaszewska E., Wlostowski T., Krasowska A., Kozlowski P.
Acta Theriologica
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2012
|
tom 57
|
nr 4
Seasonal changes in lipid droplet size and lipid peroxidation in the brown adipose tissue (BAT) of wild bank voles were examined. In addition, a role of photoperiod in these changes was studied; bank voles were held from the birth under long photoperiod (LP) for 12 weeks, and then half of them was transferred to short photoperiod (SP) for 6 weeks and another one remained under LP. In the wild bank voles the absolute BAT weight was seasonally constant, while the significant differences in the lipid droplet size were observed. The smallest lipid droplets (mean, 11 μm2) were seen in winter; they increased by 30 % in spring and reached the highest size (24 μm2) in summer. Lipid peroxidation in the BAT did not differ significantly between the seasons, although high intraseason variation of this process was noted. The laboratory experiment revealed that the size of lipid droplets was determined by photoperiod; SP induced 13-fold decrease, and continuous exposure to LP brought about a further 2.5-fold increase in the size of lipid droplets. Conversely, a significant decrease in lipid peroxidation was seen in LP bank voles in comparison with the SP animals. The data indicate that short photoperiod is responsible for the small size of lipid droplets in the BAT of bank voles during winter, which may be a necessary requirement for high thermogenic capacity of the tissue. Photoperiod appears also to affect lipid peroxidation in the BAT of these animals.
4
Content available remote

The skeletal and heart muscle triacylglycerol lipolysis revisited

84%
Knapp M., Gorski J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 1
5

Short-term fenofibrate treatment improves ultrastructure of hepatocytes of old rats

84%
Zubrzycki A., Wronska A., Zauszkiewicz-Pawlak A., Kmiec Z.
Folia Histochemica et Cytobiologica
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2021
|
tom 59
|
nr 3
6

Balbiani body in oocytes of the pseudoscorpion Chelifer cancroides (Linnaeus, 1761) (Chelicerata: Arachnida: Pseudoscorpionida) and its contribution to lipid droplets formation

67%
Jedrzejowska I., Kubrakiewicz J.
Acta Biologica Cracoviensia. Series Botanica. Supplement
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2014
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tom 56
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nr 1
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