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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Ivermectin vs. lindane in the treatment of scabies

100%
Goldust M., Rezaee E., Raghifar R., Naghavi-Behzad M.
Annals of Parasitology
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2013
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tom 59
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nr 1
Scabies is commonly treated with acaricides but the treatment of choice is still controversial. This study aimed at comparing the efficacy of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. Four hundred fourty patients with scabies were enrolled, and randomized into two groups: the first group received a single dose of oral ivermectin 200 μg/kg body weight, and the second group were treated with two applications of topical lindane lotion 1%, with a 1-week interval. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. Single dose of oral ivermectin provided a cure rate of 63.6% at the 2-week follow-up, which increased to 81.8% at the 4-week follow-up after repeating the treatment. Treatment with two applications of lindane lotion 1%, with a 1-week interval between them, was effective in 45.4% of patients at the 2-week follow-up, which increased to 63.6% at the 4-week follow-up after this treatment was repeated. Single dose ivermectin was as effective as two applications of lindane lotion 1% at the 2-week follow-up. After repeating the treatment, ivermectin was superior to lindane lotion 1% at the 4-week follow up.
2

Interaction of lindane and carbaryl with cholinesterase activity in rats

100%
Krechniak J., Englot B.
Acta Poloniae Toxicologica
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1994
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tom 02
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nr 1
3

Evaluation of the status of contamination of arable soils in Poland with DDT and HCH residues; national and regional scales

84%
Maliszewska-Kordybach B., Smreczak B., Klimkowicz-Pawlas A.
Polish Journal of Environmental Studies
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2014
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tom 23
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nr 1
The aim of our study was to evaluate the content of organochlorine pesticides (DDTs and HCHs) in the upper layer of arable soils in Poland. 214 soil samples were analyzed for the content of three HCH congeners (α-HCH, β-HCH, and γ-HCH) and three DDT compounds (pp’DDT, pp’DDE, and pp’DDD). The median soil concentration of Σ3DDT was 24.39 μg·kg⁻¹, while for Σ3HCH it was 2.85 μg·kg⁻¹ with the highest contribution of γ-HCH isomer. Polish criteria for agricultural soils not polluted with DDTs are met by half of the samples. In the case of γ-HCH the Polish limit value of 0.5 μg·kg⁻¹ was met in 6.5% of the samples. However, according to the less restrictive systems applied in other countries (Canada, Romania) none of the soil samples create a hazard due to contamination with DDTs, and only 6-11% exhibit too high concentrations of γ- HCH (residues of Lindane). The mean contents of DDTs and γ-HCH in soils from different provinces varied widely with the reverse interdependence of both groups of pesticides. The districts with the highest concentrations of DDT (Podlaskie, Wielkopolskie, and Mazowieckie) were characterized by the lowest mean residues of Lindane. This suggests the long-term effects of the prescriptive state system of distribution of pesticides used in Poland more than 40 years ago.
4
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HCH and DDT residues in human fat in the population of Murcia [Spain]

84%
Molina C., Falcon M., Barba A., Camara M. A., Oliva J., Luna A.
Annals of Agricultural and Environmental Medicine
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2005
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tom 12
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nr 1
In the Mediterranean province of Murcia (SE Spain) around 610,000 hectares of land are devoted to agriculture and organochlorine insecticide use has been common in the region for many years. To investigate HCH and DDT (isomers and metabolites) residues, a total of 231 fat samples were taken from the general population and analyzed. Organochlorine residues were found in 63.2% of the samples. The pattern of overspreading by these substances in this part of the world is similar to that described by different authors in other countries. p,p'-DDE, ß-HCH and lindane residues, in this order, show the highest occurrence in the region and also the highest mean levels. Areas devoted to greenhouses, traditional dry farming of paprika pepper, and traditional horticultural cultivation are the most contaminated. Therefore, the past use of DDT and the actual employment of lindane seem to be reflected in the residents of these areas.
5
Content available remote

Ethanol suppresed seizures in lindane-treated rats. Electroencephalographic and behavioral studies

84%
Mladenovic D., Hrncic D., Vucevic D., Radosavljevic T., Loncar-Stevanovic H., Petrovic J., Susic V., Djuric D., Stanojlovic O.
Journal of Physiology and Pharmacology
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2007
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tom 58
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nr 4
This study examines the effects of ethanol on lindane-induced seizures in rats. The animals were divided into following groups: 1. saline, 2. DMSO (dimethylsulfoxide), 3. lindane dissolved in DMSO in the dose of 4, 6 or 8 mg/kg (L4, L6 and L8 groups, respectively), 4. ethanol 2 g/kg administered 30 min prior to lindane (protected groups AL4, AL6 and AL8) and 5. ethanol alone (2 g/kg). In order to determine ethanol concentration in plasma, blood samples were collected by cardiac puncture 30 and 60 min after ethanol injection. For EEG and power spectra recordings, electrodes were implanted into the skull. The lindane treatment resulted in a dose-dependent increase of seizure incidence and severity. The rats displayed severe seizure patterns characterized by high voltage spike-wave complexes, poly-spikes and sleep-like patterns in EEG, while the power spectra were intensively elevated in comparison to the corresponding controls. Ethanol alone led to increased EEG power spectra, which became dominant in the range of 0-4 Hz. For evaluation of anticonvulsant ethanol action we compared latency to seizure, incidence and seizure severity (scale from 0 to 4) in the examined groups. Ethanol diminished seizure incidence in AL4 and AL6 groups, decreased intensity of convulsions, and prolonged duration of latency period in AL8 group. We observed suppression of the EEG signs of lindane-provoked epileptiform activity in AL4 and AL6, but not in AL8 group. These results suggest that ethanol acted protectively on lindane-induced seizures and suppressed behavioral and epileptic EEG spiking activity.
6

Influence of lindane on carbaryl biotransformation, distribution and elimination in rats

84%
Krechniak J., Englot B.
Acta Poloniae Toxicologica
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1996
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tom 04
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nr 2
7

Persistent organic pollutants (POPs) in the marine food web: herrings from the Southern Baltic Sea (Clupea harengus) - penguins from the zoo (Spheniscus demersus)

67%
Reindl A. R., Bolalek J., Falkowska L.
Oceanological and Hydrobiological Studies
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2013
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tom 42
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nr 1
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Methoxychlor, chlorfenvinphos, lindane, alfa-HCH and synthetic pyrethroids in soils of potato fields and surface waters in the South-Eastern Poland

67%
Sadlo S.
Prace Naukowe Instytutu Ochrony Roślin
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1993
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tom 35
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nr 1-2
9

Effects of joint action of some carbamate insecticides in rats

67%
Wysocka-Paruszewska B., Osicka-Koprowska A., Brzezinski J.
Acta Poloniae Toxicologica
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1995
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tom 03
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nr 2
10

Badanie radiometryczne rozmieszczenia i wydalania lindanu - 14 C w watrobie szczura

59%
Sulik M., Kemona A., Kisielewski W., Stefanska-Sulik E., Sulkowski S., Sobaniec Lotowska M.
Bromatologia i Chemia Toksykologiczna
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1994
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tom 27
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nr 3
245-250
W pracy badano dynamikę rozmieszczenia i wydalania lindanu - 14C w wątrobie szczurów. Wykonano pomiary radiometryczne zhomogenizowanej tkanki wątrobowej oraz frakcji subkomórkowych wątroby w okresie 35 dni po podaniu dożołądkowym. Wykazano, że lindan szybko wchłania się z przewodu pokarmowego i gromadzi w wątrobie. Już po upływie 1 doby stwierdzono najwyższy poziom, który następnie obniżał się wydatnie do 7 dnia, potem powoli do 14 dnia. W okresie do 35 dnia radioaktywność wątroby była niska i po 35 dniach nie stwierdzono już zawartości związków radioaktywnych.
11

Zmiany histologiczne, histochemiczne i ultrastrukturalne w watrobie szczura w przewleklym zatruciu lindanem

59%
Sulik M., Szynaka B., Sulkowska M., Kemona A., Kisielewski W., Sulik A.
Bromatologia i Chemia Toksykologiczna
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1998
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tom 31
|
nr 2
183-189
W pracy badano wpływ przewlekłego zatrucia szczurów lindanem na powstawanie i dynamikę zmian histologicznych, histochemicznych i ultrastrukturalnych w hepatocytach. Insektycydy podawano drogą pokarmową, w dawce dziennej 10 mg/kg m.c., której wysokość nie prowadziła do kumulacji związku i objawów zaostrzenia zatrucia. W wyniku przeprowadzonych badań stwierdzono występowanie w hepatocytach odwracalnych zmian adaptacyjnych oraz mniej licznych, drobnych ognisk trwałego uszkodzenia miąższu i jego zwłóknienia.
12

Toxic substances in the water, bottom sediments and organisms of the Gdansk Basin

51%
Andrulewicz E.
Oceanological Studies
|
1996
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tom 25
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nr 1-2
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