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1

Acute Ginkgo biloba facilitates decision-making in a working memory task in rats

100%
Wilson W. J., Ogg J. A., Marsack K. Z.
Acta Neurobiologiae Experimentalis
|
2000
|
tom 60
|
nr 4
2

Ludwik Hirszfeld memorial lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication

100%
Pomerantz R. J.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
tom 52
|
nr 5
3

Detection of specific lytic and latent transcripts can help to predict the status of Epstein-Barr virus infection in transplant recipients with high virus load

86%
Zawilinska B., Kosinska A., Lenart M., Kopec J., Piatkowska-Jakubas B., Skotnicki A., Kosz-Vnenchak M.
Acta Biochimica Polonica
|
2008
|
tom 55
|
nr 4
693-699
Epstein–Barr virus (EBV), a member of the family Herpesviridae, is widely spread in the human population and has the ability to establish lifelong latent infection. In immunocompetent individuals the virus reactivation is usually harmless and unnoticeable. In immunocompromised patients productive infection or type III latency may lead to EBV-associated post-transplant lymphoproliferative disorder (PTLD). The aim of our research was to investigate the utility of PCR-based methods in the diagnosis and monitoring of EBV infections in bone marrow transplant recipients. Thirty-eight peripheral blood leukocyte samples obtained from 16 patients were analysed, in which EBV DNA was confirmed by PCR. We used semi-quantitative PCR to estimate the viral load and reverse-transcription PCR (RT-PCR) to differentiate between latent and productive EBV infection. In 14 patients we confirmed productive viral infection. We observed a correlation between higher number of EBV genome copies and the presence of transcripts specific for type III latency as well as clinical symptoms.
4

The immunology of Chlamydia trachomatis

86%
Zdrodowska-Stefanow B., Ostaszewska-Puchalska I., Pucilo K.
Archivum Immunologiae et Therapiae Experimentalis
|
2003
|
tom 51
|
nr 5
5

The effect of tonic pain on processing the non-painful stimuli indexed by late components of event-related potentials

86%
Michalski A.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 1
6
Content available remote

The influence of age and gender on the latency of eye movement in healthy humans

72%
Jernajczyk W., Sobanska A., Czerwosz L., Szatkowska E.
Journal of Physiology and Pharmacology. Supplement
|
2005
|
tom 56
|
nr 4
93-97
Standard measures of sleep recordings give differing results depending on the gender and they constantly change with age. Sleep latency increases, delta sleep decreases, and sleep tend to be shorter in duration and fragmented in middle-aged and elderly adults. The deterioration of sleep is observed earlier in men. In the 1980s, new measures called the Latency of Eye Movement (LEM) and the Mean Latency of Eye Movement (M-LEM) were proposed. Previous studies have shown that untreated patients with endogenous depression had the LEM and M-LEM shortened and that both indices get prolonged during treatment with antidepressants. On the other side, alcoholics in the abstinence period have LEM and M-LEM twice as long as healthy controls. In this study we set out to compare LEM and M-LEM in healthy humans according to the gender and age. The subjects of the study were 80 healthy volunteers: 40 males and 40 females, who were divided into 4 groups: females and males, below and above 40 years of age. In contrast to standard measures, our study did not reveal any significant changes of LEM or M-LEM due to the gender or age.
7

The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A [LMP2A] in latency and cancer

72%
Pang M. F., Lin K.-W., Peh S.-C.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 2
222-247
Epstein-Barr virus (EBV) is a ubiquitous virus with infections commonly resulting in a latency carrier state. Although the exact role of EBV in cancer pathogenesis remains not entirely clear, it is highly probable that it causes several lymphoid and epithelial malignancies, such as Hodgkin’s lymphoma, NK-T cell lymphoma, Burkitt’s lymphoma, and nasopharyngeal carcinoma. EBV-associated malignancies are associated with a latent form of infection, and several of these EBV-encoded latent proteins are known to mediate cellular transformation. These include six nuclear antigens and three latent membrane proteins. Studies have shown that EBV displays distinct patterns of viral latent gene expression in these lymphoid and epithelial tumors. The constant expression of latent membrane protein 2A (LMP2A) at the RNA level in both primary and metastatic tumors suggests that this protein might be a driving factor in the tumorigenesis of EBV-associated malignancies. LMP2A may cooperate with the aberrant host genome, and thereby contribute to malignant transformation by intervening in signaling pathways at multiple points, especially in the cell cycle and apoptotic pathway. This review summarizes the role of EBV-encoded LMP2A in EBV-associated viral latency and cancers. We will focus our discussions on the molecular interactions of each of the conserved motifs in LMP2A, and their involvement in various signaling pathways, namely the B-cell receptor blockade mechanism, the ubiquitin-mediated (Notch and Wnt) pathways, and the MAPK, PI3-K/Akt, NK-κB and STAT pathways, which can provide us with important insights into the roles of LMP2A in the EBV-associated latency state and various malignancies.
8

Altered electrophysiological pattern of target detection in schizophrenia in the Continuous Attention Test

72%
Basinska A.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 3
9

How do rats cope with the two-way escape problem in a homogenous shuttle box?

72%
Savonenko A. V., Brush F. R., Zielinski K.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 2
10

Factors affecting oviposition of artificially inseminated honeybee queens

72%
Skowronek W., Kruk C., Klopot J.
Journal of Apicultural Science
|
2002
|
tom 46
|
nr 2
11

Effect of unilateral injection of MK-801 into the area of A10 cells on feeding evoked by stimulation of homologous area in the contralateral hemisphere

72%
Maliszewska-Scislo M., Trojniar W.
Acta Neurobiologiae Experimentalis
|
2000
|
tom 60
|
nr 4
It was found previously that unilateral electrolytic and 6-OHDA lesions of the ventral tegmental area (VTA) and unilateral intra-VTA injection of bicuculline resulted in facilitation of behavioral responses evoked by electrical stimulation of the symmetrical VTA area in the contralateral hemisphere. We postulated that „the contralateral facilitation effect", which may reflect the yet unexplored mechanism of immediate compensation after acute unilateral brain injury, is attributable to the A10 DA neurons and their regulatory inputs. The present study was aimed at examining the possible involvement of NMDA-mediated glutamatergic transmission in VTA in the „contralateral facilitation effect". The behavioral model of the VTA stimulation-induced feeding in rats was used. Latency to eat was measured as a function of stimulation frequency before and after unilateral intra-VTA injection of non-competitive NMDA receptors antagonist, MK-801, (doses 0.0, 1.25 and 2.5 p,g). MK-801 caused a dose-dependent augmentation of feeding evoked by stimulation of the contralateral VTA, which manifested as a decrease in the reaction frequency threshold and a leftward shift of the latency/frequency curve. Dose 2.5 replicated the facilitatory effect of electrolytic and 6-OHDA lesions. The results are interpreted in terms of MK-801-evoked depression of excitatory glutamatergic tone over A10 DA cells and compensatory increase in DA release in the contralateral hemisphere.
12

Latency of the two-way avoidance response in rats: inhibition of delay

72%
Zielinski K., Werka T., Nikolaev E.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 4
13

Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice

58%
Brito V. B., Rocha J. B. T., Folmer V., Erthal F.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 1
125-134
 In this work was investigated the effect of pre-treatment with (PhSe)2 and (PhTe)2 on chemical seizure and 4-aminopyridine-induced lethality in mice. Additionally, lipid peroxidation levels of whole brain after treatment with 4-aminopyridine and effect of pre-treatment with (PhSe)2 and (PhTe)2 on these levels were investigated. Mice were pre-treated with (PhSe)2 or (PhTe)2 (50, 100, or 150 µmol/kg) 30 min before 4-aminopyridine (12 mg/kg) administration. The treatment with 4-aminopyridine caused a significant incidence of seizures (clonic, tonic) and death. Pre-treatment with (PhSe)2 and (PhTe)2 significantly increased the latency for clonic and tonic seizures, and prevented 4-aminopyridine-induced death. Significantly, the pre-treatment with (PhSe)2 or (PhTe)2 increased the latency for clonic seizures in a dose-dependent manner. Additionally, a significant increase was observed in the brain lipid peroxidation level after treatment with 4-aminopyridine, which was significantly inhibited by pre-treatment with 150 µmol/kg (PhSe)2 or (PhTe)2. These results demonstrate that (PhSe)2 and (PhTe)2 counteract the harmful effects of 4-aminopyridine. It is possible that this effect results from modulation of the redox state of N-methyl-d-aspartate receptors and/or of Ca2+ channel activity with subsequent alteration in neurotransmitter release. Importantly, this study provides evidence for anticonvulsant and antioxidant properties of (PhSe)2 and (PhTe)2, which indicates a neuroprotective activity of these compounds.
14

Sympathetic skin response in obstructive sleep apnea syndrome

58%
Zakrzewska-Pniewska B., Przybylowski T., Byskiniewicz K., Kostera-Pruszczyk A., Droszcz W., Emeryk-Szajewska B.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 2
15

Novel environment as a stress-inducing factor. An event-related potentials study

58%
Michalski A.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 3
16

Factors influencing the responses to nest damage in the African weaver ant. Oecophylla longinoda [Latreille]

58%
Wojtusiak J., Godzinska E. J.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 2
17

Post-stress analgesia in rats with partial amygdala lesions

58%
Werka T.
Acta Neurobiologiae Experimentalis
|
1994
|
tom 54
|
nr 2
18

Differential effects of non-REM and REM sleep on sensory gating in rats

58%
Van Luijtelaar E. L. J. M., Miller C. A. F. J., Coenen A. M. L., Drinkenburg W. H. I. M., Ellenbroek B. A.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 4
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