Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 8

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  lamina propria
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
The effect of anti-IL-5 monoclonal antibodies (mAb) on the level of eosinophilia, the number of IgA plasma cells in lamina propria and the level of IL-5 in scraped mucosa of small intestine in BALB/c mice was examined. Eosinophils and plasma cells in lamina propria were assessed in frozen sections of small intestine. The level of IL-5 was monitored using capture ELISA. The influence of mAb anti-IL-5 on the total cell number and number of eosinophils was measured in the peritoneal cavity. Intraperitoneal injection of 0.5 mg anti-IL-5 mAb on the 3rd and 5th day after infection (DAI) with 200 T. spiralis larvae strongly depressed both eosinophils and IgA plasma cells response in the lamina propria on day 15th and 24th after infection. There was a positive correlation between the number of eosinophils and the level of IL-5 as well as between the number of IgA plasma cells and level of IL-5. IL-5 was essential for eosinophils and IgA response in small intestine and a partial role for IL-5 in protection against T. spiralis was observed.
The role of immunity in controlling Parastrongyloides trichosuri infections in possums needs to be known before the parasite can be used as a biological control agent or vector for DNA. Australian brushtail possums (Trichosurus vulpecula) were captured from the wild in New Zealand from a region where the specific nematode parasite P. trichosuri was common. Existing worm burdens were removed with anthelmintics. Three infections with P. trichosuri filariform larvae (5,000; 10,000; 20,000) were each truncated with anthelmintics after 7 days in an attempt to stimulate an immune response to infection. Subsequently, these possums resisted a challenge infection more effectively than untreated possums, developing a mean of 29 worms (5/10 fully resistant) compared with 127 (1/10 fully resistant) in untreated possums. Treated possums all had mucosal-like mast cells in the small intestine lamina propria and circulating antibody to a 65-85 kDa fraction of filariform larvae. In a second experiment, possums treated with the immunosuppressant dexamethasone trimethylacetate twice weekly were not significantly more susceptible to challenge with filariform larvae than were untreated possums. These results indicate that immunity was not highly-developed in the wild-caught possums, but could be stimulated artificially.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.