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The influence of heterocyclic compound - PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

100%

Potkin V. I., Shcharbin D., Denisov A. A., Paschkevich S. G., Bryszewska M., Petkevich S. K., Kletskov A. V., Lapotko D. O., Kazbanov V. V., Gurinovich T. A., Kulchitsky V. A.

Cellular and Molecular Biology Letters

2014

tom 19

nr 2

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

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Synthesis and fungicidal activity of substituted isoxazolecarboxamides

80%

Gucma M., Golebiewski W., Michalczyk A.

Pestycydy

2010

nr 1-4

Several new 3-substituted isoxazolecarboxamides have been prepared from aromatic and aliphatic aldehydes. A key step was a 1,3-dipolar cycloaddition of nitrile oxides to ethyl acrylate or methacrylate esters. Some of the amides showed high fungicidal activities against Alternaria alternate, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum strains.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Pestycydy

1 Bryszewska M.

1 Denisov A. A.

1 Golebiewski W.

1 Gucma M.

1 Gurinovich T. A.

1 Kazbanov V. V.

1 Kletskov A. V.

1 Kulchitsky V. A.

1 Lapotko D. O.

1 Michalczyk A.

1 Paschkevich S. G.

1 Petkevich S. K.

1 Potkin V. I.

1 Shcharbin D.

1 2014

1 2010

Wyniki wyszukiwania

The influence of heterocyclic compound - PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

Synthesis and fungicidal activity of substituted isoxazolecarboxamides