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Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata

100%

Adeyemi D. O., Komolafe O. A., Adewole O. S., Obuotor E. M., Abiodun A. A., Adenowo T. K.

Folia Morphologica

2010

tom 69

nr 2

Microanatomical changes in the pancreatic islet cells of streptozotocin induced diabetic Wistar rats were studied after treatment with methanolic extracts of Annona muricata leaves. Thirty adult Wistar rats were randomly assigned into three groups (control, untreated diabetic group, and A. muricata-treated diabetic group) of ten rats each. Diabetes mellitus was experimentally induced in groups B and C by a single intra-peritoneal injection of 80 mg/kg streptozotocin dissolved in 0.1 M citrate buffer. The control rats were intraperitoneally injected with an equivalent volume of citrate buffer. Daily intra peritoneal injections of 100 mg/kg A. muricata were administered to group C rats for two weeks. Post sacrifice the pancreases of the rats were excised and fixed in Bouin’s fluid. The tissues were processed for paraffin embedding and sections of 5 µm thickness were produced and stained with H & E, Gomori aldehyde fuchsin, and chrome alum haematoxylin-phloxine for demonstration of the β-cells of islets of pancreatic islets. Histomorphological and morphometric examination of the stained pancreatic sections showed a significant increase in the number, diameter, and volume of the β-cells of pancreatic islets of the A. muricata-treated group (5.67 ± 0.184 N/1000 µm², 5.38 ± 0.093 µm and 85.12 ± 4.24 µm³, respectively) when compared to that of the untreated diabetic group of rats (2.85 ± 0.361 N/1000 µm², 2.85 ± 0.362 µm and 69.56 ± 5.216 µm³, respectively). The results revealed regeneration of the β-cells of islets of pancreatic islet of rats treated with extract of A. muricata. (Folia Morphol 2010; 69, 2: 92–100)

Nonspecific alkaline phosphatase activity can be responsible for staining of NADPH-diaphorase activity in certain non-neural cells

80%

Grozdanovic Z., Gossrau R.

Folia Histochemica et Cytobiologica

1995

tom 33

nr 1

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Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion

70%

Bilski J., Konturek S. J., Bielanski W.

Journal of Physiology and Pharmacology

1995

tom 46

nr 4

Ograniczanie wyników

1 Folia Histochemica et Cytobiologica

1 Folia Morphologica

1 Journal of Physiology and Pharmacology

1 Abiodun A. A.

1 Adenowo T. K.

1 Adewole O. S.

1 Adeyemi D. O.

1 Bielanski W.

1 Bilski J.

1 Gossrau R.

1 Grozdanovic Z.

1 Komolafe O. A.

1 Konturek S. J.

1 Obuotor E. M.

1 2010

2 1995

Wyniki wyszukiwania

Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata

Nonspecific alkaline phosphatase activity can be responsible for staining of NADPH-diaphorase activity in certain non-neural cells

Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion