Wyniki wyszukiwania

1

Plasma homocysteine level and the course of ischemic stroke

100%

Pniewski J., Chodakowska-Zebrowska M., Wozniak R., Stepien K., Stafiej A.

Acta Neurobiologiae Experimentalis

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2003

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tom 63

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nr 2

2

Cerebroprotective effect of angiotensin IV in experimental ischemic stroke in the rat mediated by AT4 receptors

100%

Faure S., Chapot R., Tallet D., Javellaud J., Achard J. M., Oudart N.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

Recent studies have reported potential roles of angiotensins in an adaptative physiological mechanism of protection against cerebral ischemia-induced neurological damages. In the present study, we examined the protective role of angiotensin IV (AngIV) in a rat model of embolic stroke induced by intracarotid injection of calibrated microspheres (50 µm). Internal carotid infusions of increasing doses of AngIV (0.01, 0.1 and 1 nmol/0.1 mL saline) dose dependently decreased mortality, neurological deficit and cerebral infarct size at 24 hours. With the highest dose of AngIV, mortality was reduced from 55 % in saline infused controls to 10 % (p=0.003), neurological deficit was reduced from 3.8 ± 0.3 to 1.4 ± 0.3 , (p<0.0001) and cerebral infarct size at 24 hours was decreased from 432 ± 26 mm3 to 185 ± 19, (p=0.0001). The AT4 antagonist divalinal-AngIV (10-9 mol/0.1 mL), or pretreatment with L-NAME (10-7 mol/0.1 mL), both completely abolished the protective effect of AngIV (1 nmol). The AT2 antagonist PD123319 (10-7 mol/0.1 mL) partially prevented the protective effect of AngIV on the neurological score. Sequential cerebral arteriographies revealed that AngIV induced a redistribution of blood flow to the ischemic areas within minutes. These results suggest that pharmacological doses of AngIV are protective against acute cerebral ischemia by triggering an AT4-mediated, NO-dependent intracerebral hemodynamic mechanism.

3

An exonic G894T variant of endothelial nitric oxide synthase gene as a risk factor for ischemic stroke in North Indians

86%

Kaur K., Uppal A., Kaur A.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 4

Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) enzyme is a critical regulator of cerebrovascular homeostasis. Genetic variability of G894T and intronic 4ab polymorphism in eNOS could affect the expression and activity of eNOS enzyme, modulating NO levels in endothelium. This results in endothelial dysfunction, which can contribute to the pathogenesis of ischemic stroke. The purpose of the study was to evaluate the association of eNOS genetic polymorphisms (G894T and 4ab) with the occurrence of ischemic stroke through various genetic models. Both polymorphisms were genotyped in 120 ischemic stroke patients diagnosed with MRI and other ancillary techniques and 101 control subjects free of neurological abnormalities, using PCR-RFLP technique and direct PCR respectively. The genotypes of both G894T and 4ab variants were found to be in Hardy Weinberg equilibrium for cases and controls. The significant variation was observed in the genotypic and allelic frequencies for G894T polymorphism between cases and controls, indicating the association of G894T variability with ischemic stroke. However, the difference between cases and controls was insignificant for eNOS 4ab polymorphism with regard to genotypic and allelic distribution. Except for recessive model, both dominant (GT/TT vs. GG) and co-dominant (TT vs. GT or GT vs. GG) models indicated nearly two-fold and 1.93 increased risk of ischemic stroke for G894T polymorphism, but none of them suggested the influence of eNOS 4ab polymorphism on ischemic stroke susceptibility. Haplotype analysis revealed the higher frequency of GT-4bb genotype combination in cases as compared to controls, but without significant difference. The study concluded that SNP G894T variant is associated with ischemic stroke and might contribute to ischemic stroke susceptibility in North Indians. However, this outcome needs to be confirmed by studies with large sample size.

4

The role of chemokine CCL5/RANTES and metalloproteinase-9 as inflammatory modulators in symptomatic internal carotid artery stenosis

86%

Badacz R., Podolec J., Przewlocki T., Siedlinski M., Jozefczuk E., Oleksy H., Baran J., Pieniazek P., Zmudka K., Kablak-Ziembicka A.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 4

5

Transplantation of autologous bone marrow stromal cells (BMSC) for ischemic stroke - strategy and tactics for clinical application

86%

Kuroda S.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

Objective: There is increasing evidence that the transplanted bone marrow stromal cells (BMSC) significantly promote functional recovery after central nervous system damage in the animal models of various kinds of CNS disorders, including cerebral infarct. However, there are several shortages of information when considering clinical application of BMSC transplantation for patients with neurological disorders. In this meeting, therefore, we discuss what we should clarify to establish cell transplantation therapy in clinical situation and describe our recent works for this purpose. Methods and Results: The BMSC have multiple abilities to differentiate into the neural cells and to promote neuronal survival and axon elongation, contributing to rebuild the neural circuits in the injured CNS. Using optical imaging and MRI techniques, the transplanted BMSC can non-invasively be tracked in the living animals for at least 8 weeks after transplantation. Clinical MR apparatus can visualize the tagged BMSC in the brain. FDG PET is quite valuable to monitor the recovery of brain metabolism after transplantation. The BMSC can be expanded using the animal protein-free culture medium within a clinically relevant period. G-CSF is useful to enhance their proliferation when the BMSC are obtained from the aged patients. There are optimal dose and timing of BMSC transplantation to yield significant therapeutic benefits. Conclusion: It is urgent issues to develop clinical imaging technique to track the transplanted cells in the CNS and evaluate the therapeutic significance of BMSC transplantation to establish it as a definite therapeutic strategy in clinical situation in very near future.

6

Sleep disordered breathing and recurrence of cerebrovascular events, case-fatality, and functional outcome in patients with ischemic stroke or transient ischemic attack

86%

Rola R., Jarosz H., Wierzbicka A., Wichniak A., Richter P., Ryglewicz D., Jernajczyk W.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

615-621

7

Protein kinase C expression and activity in the human brain after ischaemic stroke

86%

Krupinski J., Slevin M. A., Kumar P., Gaffney J., Kaluza J.

Acta Neurobiologiae Experimentalis

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1998

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tom 58

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nr 1

8

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke

72%

Cieslak M., Wojtczak A., Cieslak M.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Pro-inflammatory cytokines participate in the induction of ischemic stroke. So far, their participation in the cerebral ischemia was proven for the tumor necrosis factor TNF-α, interleukin-1 (IL-1), and interleukin-6 (IL-6). The release of the pro-inflammatory cytokines into the extracellular space causes the enlargement of the brain damage region, and consequently increases the neurological deficit and negatively affects the survival rate prognoses. That is confirmed by the increased concentration of pro-inflammatory cytokines in blood and the cerebrospinal fluid of patients with brain stroke, as well as by the research on the induced/experimental cerebral ischemia in animals. The pro-inflammatory cytokines participate in the migration of the reactive T lymphocytes to the regions of brain ischemia where they enhance the nerve tissue damage by down-regulation of microcirculation, induce the pro-thrombotic processes and release other neurotoxic cytokines. Also, in the early stage of cerebral ischemia, cytokines activate the axis hypothalamus-pituitary gland-adrenal cortex and increase the cortisol concentration in blood, what results in the decreased resistance to infectious diseases. Administration of the inhibitor of the interleukin-1 receptor (IL-1Ra) inhibits the inflammatory processes in the region of brain ischemia, and subsequently improves the prognosis for the size of the neurological deficit and the survival rate, as well as resistance to infectious diseases.

9

Clearing the fog: Changes in T2 relaxation time after stroke reflect clearing processes

72%

Kranz A., Deten A., Haertig W., Boltze J., Wagner D. C.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

CT and MR imaging techniques are frequently used for the diagnosis and progress monitoring of ischemic stroke in clinical practice and research. After stroke, both methods are characterized by a transient pseudo-normalized imaging signal, the so-called fogging phenomenon. This study evaluates potential pathophysiological changes associated with fogging, as well as its influence on the correct determination of the ischemic lesion in a rat stroke model. Male spontaneously hypertensive rats were subjected to permanent middle cerebral artery occlusion. Ischemic lesion volume, brain edema and grey scale value spread within the ischemic lesion were determined on T2-weighted MR sequences at days 1, 4, 8, 11 and 29 after stroke onset, and compared with immunohistochemistry for astrogliosis, microglia/macrophage infiltration and angiogenesis. All animals showed MR fogging at days 4, 8 and 11 after stroke. The transient normalization of T2 signals occurred independently from the development of infarct volumes, but coincided well with the spatio-temporal occurrence of necrosis, angiogenesis and microglia/macrophage infiltration. Our results suggest that the fogging effect reflects the clearance of necrotic tissue within the ischemic lesion and is thus not relevant for the determination of the lesion volume.

10

Sleep related breathing disorders in patients with ischemic stroke and transient ischemic attacks: respiratory and clinical correlation

72%

Rola R., Wierzbicka A., Wichniak A., Jernajczyk W., Richter P., Ryglewicz D.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

11

Circadian rhythms of melatonin and cortisol in manifest Huntington's disease and in acute cortical ischemic stroke

72%

Adamczak-Ratajczak A., Kupsz J., Owecki M., Zielonka D., Sowinska A., Checinska-Maciejewska Z., Krauss H., Michalak S., Gibas-Dorna M.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 4

12

C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects

72%

Goracy I., Cyrylowski L., Kaczmarczyk M., Fabian A., Koziarska D., Goracy J., Ciechanowicz A.

Journal of Applied Genetics

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2009

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tom 50

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nr 1

63-67

Hyperhomocysteinemia is reported to be an independent risk factor for the development of ischemic stroke. Several studies on genetic variants of methylenetetrahydrofolate reductase (MTHFR, which plays a crucial role in regulation of plasma homocysteine concentration) reported an association between C677T gene polymorphism and stroke in some Asian populations. No study but one detected this association in Caucasians. The purpose of the present case-control study was to find a relationship between MTHFR genotypes and stroke in a Polish population. MTHFR genotypes were determined by PCR in 152 patients with ischemic stroke from northwestern Poland and in 135 consecutive newborns from the same population. The TT genotype and the T allele were significantly more frequent in patients than in the control group (11.8% vs. 4.4%, and 34.5% vs. 21.5%, P < 0.01). When males and females were analyzed separately, the differences were statistically significant in both genders. It is concluded that presence of the T allele is a risk factor for ischemic stroke in Polish subjects.

13

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Acute ischemic stroke within the area of MCA from ICA thrombosis complicating moderate COVID-19 infection

72%

Kurys-Denis E., Prystupa A., Sak J.

Journal of Pre-Clinical and Clinical Research

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2021

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tom 15

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nr 1

14

The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis

58%

Lasek-Bal A., Jedrzejowska-Szypulka H., Student S., Warsz-Wianecka A., Zareba K., Puz P., Bal W., Pawletko K., Lewin-Kowalik J.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 2

15

Pathophysiological mechanisms of carotid plaque vulnerability: impact on ischemic stroke

58%

Pelisek J., Eckstein H.-H., Zernecke A.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

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nr 6

16

Zmiany statusu antyoksydacyjnego w korze mozgowej czlowieka po zatruciu heroina

37%

Gutowicz M., Cholojczyk M., Siwinska-Ziolkowska A., Pokorska-Lis M., Szymczakowski S., Sadurska B., Baranczyk-Kuzma A.

Bromatologia i Chemia Toksykologiczna

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2004

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tom 37

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nr 3

277-282

W pracy przedstawiono aktywność seleno-niezależnej peroksydazy glutationowej i katalazy, poziom zredukowanego glutationu, dialdehydu malonowego i grup karbonylowych W rożnych częściach kory mózgowej człowieka. Badania prowadzono na tkankach otrzymywanych z autopsji osób zmarłych na skutek zatrucia heroiną

Ograniczanie wyników

Plasma homocysteine level and the course of ischemic stroke

Cerebroprotective effect of angiotensin IV in experimental ischemic stroke in the rat mediated by AT4 receptors

An exonic G894T variant of endothelial nitric oxide synthase gene as a risk factor for ischemic stroke in North Indians

The role of chemokine CCL5/RANTES and metalloproteinase-9 as inflammatory modulators in symptomatic internal carotid artery stenosis

Transplantation of autologous bone marrow stromal cells (BMSC) for ischemic stroke - strategy and tactics for clinical application

Sleep disordered breathing and recurrence of cerebrovascular events, case-fatality, and functional outcome in patients with ischemic stroke or transient ischemic attack

Protein kinase C expression and activity in the human brain after ischaemic stroke

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke

Clearing the fog: Changes in T2 relaxation time after stroke reflect clearing processes

Sleep related breathing disorders in patients with ischemic stroke and transient ischemic attacks: respiratory and clinical correlation

Circadian rhythms of melatonin and cortisol in manifest Huntington's disease and in acute cortical ischemic stroke

C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects

Acute ischemic stroke within the area of MCA from ICA thrombosis complicating moderate COVID-19 infection

The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis

Pathophysiological mechanisms of carotid plaque vulnerability: impact on ischemic stroke

Zmiany statusu antyoksydacyjnego w korze mozgowej czlowieka po zatruciu heroina