Wyniki wyszukiwania - AGRO

1

Thymocyte-macrophage interactions. Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages

100%

Zimecki M., Wieczorek Z., Kapp J. A.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 3

2

Characterization of NO and cytokine release by transplantable melanoma cell lines in relationship to their differentiation

86%

Kozlowska K., Zarzeczna M., Cichorek M.

Archivum Immunologiae et Therapiae Experimentalis. Supplement

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2001

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tom 49

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nr 2

103-109

3

Effect of IL-6 deficiency on myocardial expression of fatty acid transporters and intracellular lipid deposits

86%

Chabowski A., Zmijewska M., Gorski J., Bonen A., Kaminski K., Winnicka M. M.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 1

IL-6 is a biologically active substance and is thought to contribute to the development of obesity. Recent findings suggest that susceptibility to intracellular lipid accumulation is to a large extent determined by changes in the expression of fatty acid transporters such as FAT/CD36, FABPpm and FATP-1. The aim of the present study was to determine the effect of IL-6 deficiency on the expression of fatty acid transporters, as well as, assess the concomitant changes in intracellular lipids. We found that Il-6 deficiency upregulated the myocardial expression of FAT/CD36 (+40%) and did not significantly affect the content of FABPpm and FATP-1 (+15% and +5% respectively). Although no change in the intramyocardial total lipid content was noted, there was a significant increase in the intracellular content of both free fatty acid (FFA), diacylglicerol (DG) and ceramide fractions (+45%, +37% and +48%, respectively) in hearts from IL-6 -/- mice. A trend for IL-6 deficiency to increase in saturated FA species in these fractions was also observed (+8%, +12% and +10%, respectively). In contrast, IL-6 deficiency has no effect on the content of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) species in each intramyocardial lipid fractions examinated. These findings suggest that IL-6 deficiency results in 1) upregulation of myocardial content of FAT/CD36, 2) the increase in the content of biologically active lipid pools (FFA, DG and ceramide). This lipid accumulation with concomitant trend for increase in the saturation status of these lipid fractions may, at least in part, provide a factor related to the development of intramyocardial lipotoxicity, observed in obese individuals.

4

Bacteriophages provide regulatory signals in mitogen-induced murine splenocyte proliferation

86%

Zimecki M., Weber-Dabrowska B., Lusiak-Szelachowska M., Mulczyk M., Boratynski J., Pozniak G., Syper D., Gorski A.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 3

The aim of this investigation was to reveal the regulatory properties of bacteriophage preparations in a model of mitogen-induced splenocyte proliferation in mice. We showed that sepharose 4B-purified preparations of the Staphylococcus aureus phage A20/R exhibited costimulatory activity in splenocyte proliferation induced by suboptimal (0.25 μg/ml) concentrations of ConA. On the other hand, the purified phage fraction was regulatory with regard to splenocyte proliferation induced by the optimal (2.5 μg/ml) ConA concentration. We also showed that the phage preparation can elicit IL-6 production in splenocyte cultures and enhance ConA-induced production of that cytokine. Furthermore, the phages preferentially induced IL-6 production in adherent splenocytes and increased levels of that cytokine in cultures of peritoneal cells from mice and rats. This phenomenon may explain the costimulatory activity of phages in the model described.

5

Synthesis and biological studies on analogs of cyclolinopeptide A with a shortened peptide chain

86%

Siemion I. Z., Pedyczak A., Strug I., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 5-6

6

Association of interferon gamma, tumor necrosis factor alpha and interleukin 6 serum levels with systemic lupus erythematosus activity

86%

Robak E., Sysa-Jedrzejewska A., Dziankowska B., Torzecka D., Chojnowski K., Robak T.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 6

7

Interleukin 6 production by mononuclear phagocytes can be stimulated by leukotrienes

86%

Stankova J., Rola-Pleszczynski M.

Archivum Immunologiae et Therapiae Experimentalis

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1992

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tom 40

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nr 1

8

Interleukin-6 biology is coordinated by membrane bound and soluble receptors

86%

Rose-John S.

Acta Biochimica Polonica

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2003

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tom 50

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nr 3

Cytokine receptors exist in membrane bound and soluble form. Both forms bind their ligands with comparable affinity. While most soluble receptors are antagonists in that they compete for the ligands with their membrane counterparts, some soluble receptors are agonists. In this case, the complex of ligand and soluble receptor binds on target cells to a second receptor subunit and initiates signal transduction. Soluble receptors of the IL-6 family of cytokines are agonists. In vivo, the IL-6/soluble IL-6R complex stimulates several types of target cells not stimulated by IL-6 alone, since they do not express the membrane bound IL-6R. This process has been named transsignaling. We have shown that in several chronic inflammatory diseases like chronic inflammatory bowl disease, peritonitis and rheumatoid arthritis, transsignaling via the soluble IL-6R complexed to IL-6 is a crucial point in the transition from the acute to the chronic state of the disease. The mechanism by which the IL-6/ soluble IL-6R complex regulates the inflammatory state is discussed.

9

Interleukin 6 and its soluble receptor in periodontitis

86%

Pietruska M., Pietruski J. K., Stokowska W., Jablonska E.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 5

10

Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation

86%

May P., Schniertshauer U., Gerhartz C., Horn F., Heinrich P. C.

Acta Biochimica Polonica

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2003

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tom 50

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nr 3

Interleukin-6 is a potent inducer of acute-phase response gene transcription. The intracellular signal transduction mechanisms by which this and other biological effects of the cytokine are achieved include activation of the JAK-STAT signaling pathway. More specifically, activation of the signal transducers and activators of transcription STAT1, 3, and 5 in response to IL-6 has been described. We examined the relative potency of these three STAT factors for the activation of acute-phase gene promoters in HepG2 cells in a reporter gene-based assay, where specific STAT factors could be activated via recombinant receptor constructs bearing different STAT-recruiting modules. These experiments indicate that amongst the STAT factors known to be activated by IL-6 STAT3 is the most potent activator of acute-phase gene transcription.

11

Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells

86%

Zimecki M., Spiegel K., Wlaszczyk A., Kubler A., Kruzel M. L.

Archivum Immunologiae et Therapiae Experimentalis

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1999

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tom 47

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nr 2

12

The ability of Candida spp. strains to induce production of tumor necrosis factor and interleukin-6 by whole blood cells

86%

Nawrot U., Grzybek-Hryncewicz K., Czarny A.

Acta Microbiologica Polonica

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2003

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tom 52

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nr 1

13

The immunomodulatory activity of Staphylococcus aureus products derived from biofilm and planktonic cultures

72%

Sadowska B., Wieckowska-Szakiel M., Paszkiewicz M., Rozalska B.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 5

14

Investigation of seminal plasma chitotriosidase-1 and leukocyte elastase as potential markers for ‘silent’ inflammation of the reproductive tract of the infertile male - a pilot study

72%

Kratz E. M., Zurawska-Plaksej E., Solkiewicz K., Kokot I., Faundez R., Piwowar A.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 3

15

Sulodexide modulates the dialysate effect on the peritoneal mesothelium

72%

Misian M., Baum E., Breborowicz A.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 6

16

Fisetin attenuates cartilage destruction in adjuvant-induced arthritis by modulating cartilage cytokine expression correlated with oxidative status in the early phase in experimental animals

72%

Li X., Guo D., Zhao J., Wu X., Wang H., Ma S., Zhao Y., Ma X.

Folia Biologica

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2019

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tom 67

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nr 4

17

A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis

72%

Grigorescu M., Crisan D., Radu C., Grigorescu M. D., Sparchez Z., Serban A.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 4

18

Effects of resveratrol on the expression and DNA methylation of cytokine genes in diabetic rat aortas

72%

Lou X.-D., Wang H.-D., Xia S.-J., Skog S., Sun J.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 4

19

Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma

72%

Grzela K., Zagorska W., Krejner A., Litwiniuk M., Zawadzka-Krajewska A., Banaszkiewicz A., Kulus M., Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 3

20

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

72%

Kowalczyk A., Kleniewska P., Kolodziejczyk M., Skibska B., Goraca A.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 1

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