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  1. 17 Journal of Physiology and Pharmacology

  2. 7 Journal of Physiology and Pharmacology. Supplement

  3. 3 Polish Journal of Veterinary Sciences

  4. 2 Archivum Immunologiae et Therapiae Experimentalis

  5. 1 Acta Biochimica Polonica

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  1. 3 Grzelkowska-Kowalczyk K.

  2. 3 Rychlewski T.

  3. 3 Szczesniak L.

  4. 2 Bogdanski P.

  5. 2 Brazert J.

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  1. 2 2020

  2. 3 2019

  3. 1 2018

  4. 1 2017

  5. 2 2013

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1
Content available remote

Association between PNPLA3[G]/I148M variant, steatosis and fibrosis stage in hepatitis C virus - genetics matters

100%
Crisan D., Grigorescu M., Crisan N., Craciun R., Lupsor M., Radu C., Grigorescu M. D., Suciu A., Epure F., Avram L., Leach N.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 4
2

Structure and physiological functions of the human peroxisome proliferator-activated receptor gamma

100%
Zieleniak A., Wojcik M., Wozniak L. A.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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tom 56
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nr 5
3
Content available remote

Ambivalent role of gallated catechins in glucose tolerance in humans: A novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption

84%
Park J. H., Jin J. Y., Baek W. K., Park S. H., Sung H. Y., Kim Y. K., Lee J., Song D. K.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 4
101-109
Prolonged postprandial hyperglycemia is a detrimental factor for type 2 diabetes and obesity. The benefit of green tea extract (GTE) consumption still requires confirmation. We report the effects of circulating green tea catechins on blood glucose and insulin levels. Oral glucose loading 1 h after GTE ingestion in humans led to higher blood glucose and insulin levels than in control subjects. Gallated catechins were required for these effects, although within the intestinal lumen they have been known to decrease glucose and cholesterol absorption. Treatment with epigallocatechin-3-gallate hindered 2-deoxyglucose uptake into liver, fat, pancreatic beta-cell, and skeletal muscle cell lines. The glucose intolerance was ameliorated by gallated catechin-deficient GTE or GTE mixed with polyethylene glycol, which was used as an inhibitor of intestinal absorption of gallated catechins. These findings may suggest that the gallated catechin when it is in the circulation elevates blood glucose level by blocking normal glucose uptake into the tissues, resulting in secondary hyperinsulinemia, whereas it decreases glucose entry into the circulation when they are inside the intestinal lumen. These findings encourage the development of non-absorbable derivatives of gallated catechins for preventative treatment of type 2 diabetes and obesity, which would specifically induce only the positive luminal effect.
4
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Components of metabolic syndrome and their impact on fetal growth in women with gestational diabetes mellitus

84%
Zawiejska A., Wender-Ozegowska E., Brazert J., Sodowski K.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 4
5-18
5
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A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis

84%
Grigorescu M., Crisan D., Radu C., Grigorescu M. D., Sparchez Z., Serban A.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 4
6
Content available remote

Assessment of leptin-to-adiponectin ratio in prediction of insulin resistance and nutrition status in a geriatric female population

84%
Biercewicz M., Slusarz R., Kedziora-Kornatowska K., Filipska K., Bielawski K., Ruszkowska-Ciastek B.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 1
7

Metformin decreases the expression of VEGF-A and CTGF-1 and improves histological, ultrastructural and hormonal changes in adult rat polycystic ovary

84%
Attia G. M., Elmansy R. A., Elsayed M. H.
Folia Biologica
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2019
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tom 67
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nr 1
8

Serum concentration of visfatin is decreased in patients with chronic heart failure

84%
Straburzynska-Migaj E., Pilaczynska-Szczesniak L., Nowak A., Straburzynska-Lupa A., Sliwicka E., Grajek S.
Acta Biochimica Polonica
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2012
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tom 59
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nr 3
 Background. There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. Aim. The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism and high sensitivity C-reactive protein (hsCRP) levels. Material/Subjects and Methods. The study population consisted of 28 males with systolic HF referred for cardiopulmonary exercise testing, divided into two subgroups based on their NYHA class (HF patients NYHAI+II, n=17, and HF patients NYHAIII+IV, n=11), and 23 controls. The following indices were measured in a serum samples: visfatin, hsCRP, glucose and lipid metabolism parameters, and the insulin resistance index HOMAIR (homeostasis model assessment insulin resistance) was calculated. Results. Concentrations of visfatin and high-density lipoprotein cholesterol (HDL-cholesterol) in the HF subjects were significantly lower (p ≤ 0.01) than in controls. The Kruskal-Wallis test showed significant differences between three groups (controls and both subgroups of heart failure patients) in mean levels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol. Conclusion. Serum visfatin concentrations in patients with systolic HF, particularly with more advanced NYHA classes, are significantly lower in comparison to healthy controls and are independent of age or anthropometric and metabolic parameters.
9
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Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1

84%
Padilla J., Jenkins N. T.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 5
10
Content available remote

The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels

84%
Krawczyk M., Gruenhage F., Mahler M., Tirziu S., Acalovschi M., Lammert F.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 3
Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease. Additionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones. Here we assessed whether the PNPLA3 p.I148M (c.444 C>G) polymorphism affects glucose and lipid levels and increases gallstone risk. We analysed 229 individuals with gallstones from 108 families (age 24-80 years, BMI 17-55 kg/m2) and 258 gallstone-free controls (age 20-70 years, BMI 14-43 kg/m2). Fasting glucose, triglyceride and cholesterol serum levels were determined. The p.I148M polymorphism was genotyped using a PCR-based assay with 5'-nuclease and fluorescence detection. Case-control association tests and nonparametric linkage (NPL) analysis in sib-pairs were performed. Individuals carrying the [GG] genotype had significantly (P<0.0001) higher median fasting glucose levels as compared to [GC] and [CC] carriers. After adjustment for multiple testing, we detected a trend for an association between triglyceride levels and variant adiponutrin in gallstone patients (P=0.032), and gallstone cases carrying the genotype [CC] presented with significantly higher triglyceride levels than the corresponding controls (P<0.003). No significant effects on cholesterol metabolism were detected. Neither genotype distributions nor NPL scores provided evidence for association or linkage between the PNPLA3 variant and gallstones. In conclusion, homozygous carriers of the PNPLA3 risk allele display higher fasting glucose. Although this adiponutrin variant may affect triglyceride homeostasis, it does not increase the risk of cholelithiasis.
11

Nonalcoholic fatty liver disease as a feature of the metabolic syndrome

84%
Socha P., Wierzbicka A., Neuhoff-Murawska J., Wlodarek D., Podlesny J., Socha J.
Roczniki Państwowego Zakładu Higieny
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2007
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tom 58
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nr 1
The main features of the metabolic syndrome are obesity, insulin resistance and disturbed lipid metabolism. The same disturbances are regarded to be involved into the pathomechanism of nonalcoholic fatty liver disease which is shown by epidemiological studies and animal models. Thus NAFLD can be regarded a specific feature of the metabolic syndrome and it should be looked for in high risk populations.
12
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Oxidative stress and inflammatory markers in prediabetes and diabetes

67%
Luc K., Schramm-Luc A., Guzik T. J., Mikolajczyk T. P.
Journal of Physiology and Pharmacology
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2019
|
tom 70
|
nr 6
13

A novel single-nucleotide polymorphism of the visfatin gene and its associations with performance traits in the chicken

67%
Han R.-L., Lan X.-Y., Zhang L.-Z., Ren G., Jing Y.-J., Li M.-J., Zhang B., Zhao M., Guo Y.-K., Kang X.-T., Chen H.
Journal of Applied Genetics
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2010
|
tom 51
|
nr 1
59-65
Visfatin is a peptide that is predominantly expressed in visceral adipose tissue and is hypothesized to be related to obesity and insulin resistance. In this study, a novel silent single-nucleotide polymorphism (SNP) was found in exon 7 of the chicken visfatin gene (also known as PBEF1) by single-stranded conformation polymorphism (SSCP) and DNA sequencing. In total, 836 chickens forming an F₂ resource population of Gushi chicken crossed with Anka broiler were genotyped by Xbal forced RFLP, and the associations of this polymorphism with chicken growth, carcass characteristics, and meat quality were analyzed. Significant associations were found between the polymorphism and 4-week body weight (BW4), 6-week body weight (BW6), 4-week body slanting length (BSL4), fat bandwidth (FBW), breast muscle water loss rate (BWLR) and breast muscle fiber density (BFD) (P < 0.05), as well as 4-week breastbone length (BBL4) (P < 0.01). These observations suggested that the polymorphism in exon7 of the visfatin gene had significant effects on the early growth traits of chicken.
14
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The influence of orlistat, metformin and diet on serum levels of insulin-like growth factor-1 in obese women with and without insulin resistance

67%
Kujawska-Luczak M., Szulinska M., Skrypnik D., Musialik K., Swora-Cwynar E., Kregielska-Narozna M., Markuszewski L., Grzymislawski M., Bogdanski P.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 5
15
Content available remote

The role of IL-6 in mediating the anti-inflammatory effects of exercise

67%
Petersen A. M. W., Pedersen B. K.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 10
43-51
Regular exercise offers protection against all cause mortality and there is evidence from randomised intervention studies that physical training is effective as a treatment in patients with chronic heart diseases, type 2 diabetes and symptoms related to the metabolic syndrome. Chronic diseases such as cardiovascular disease, type 2 diabetes and cancer are associated with chronic low-grade systemic inflammation. It has been demonstrated that regular exercise induces anti-inflammatory effects with elevated levels of anti-inflammatory cytokines and suppression of TNF-alpha production. Thereby, exercise offers protection against TNF-alpha-induced insulin resistance. Otherwise, the exercise-induced production and release of IL-6 from myofibers may contribute to abrogate an atherogenic lipid profile, which is often associated with chronic diseases. This review focuses on the anti-inflammatory effects of exercise and how this may contribute to mediate the beneficial health effects of exercise training in patients with chronic diseases associated with chronic low-grade inflammation.
16
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Metabolic syndrome in type 1 diabetes mellitus. Does it have any impact on the course of pregnancy?

67%
Wender-Ozegowska E., Zawiejska A., Michalowska-Wender G., Iciek R., Wender M., Brazert J.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 5
17
Content available remote

Resistin is not a useful insulin resistance marker for non-obese patients

67%
Pastusiak K., Kregielska-Narozna M., Bogdanski P.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 3
18
Content available remote

Adipohormones as prognostic markers in patients with nonalcoholic steatohepatitis [NASH]

67%
Krawczyk K., Szczesniak P., Kumor A., Jasinska A., Omulecka A., Pietruczuk M., Orszulak-Michalak D., Sporny S., Malecka-Panas E.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
|
nr 3
71-75
19
Content available remote

Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles

67%
Zendzian-Piotrowska M., Baranowski M., Zabielski P., Gorski J.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 10
101-114
Ceramide is involved in the pathogenesis of insulin resistance in skeletal muscles of humans and rodents. However, there are conflicting reports in the literature on the effect of thiazolidinediones (a new class of insulin sensitizing drugs) on skeletal muscle ceramide content. Therefore, the aim of our study was to examine the effect of pioglitazone on the level of ceramide and its metabolites and on the activity of the key enzymes of ceramide metabolism in different skeletal muscle types of the rat. The experiments were carried out on rats fed either a standard chow or a high-fat diet for 21 days. Each group was divided into two subgroups: control and treated with pioglitazone for 14 days. High-fat diet increased the content of ceramide in the soleus and in the red section of the gastrocnemius, but not in the white section of the latter. The activity of neutral Mg2+-dependent sphingomyelinase and acid sphingomyelinase was simultaneously reduced in all examined muscles. Administration of pioglitazone decreased ceramide level in the soleus and in the red section of the gastrocnemius in rats fed either diet. This effect could not be attributed to decreased rate of ceramide formation from sphingomyelin or to its augmented deacylation to sphingosine. Pioglitazone treatment reduced the concentration of plasma free fatty acids in rats fed on either diet. Therefore, we conclude that the drug decreased the muscle content of ceramide by reducing its de novo synthesis. The results of our study indicate that reduction in ceramide level may be one of the mechanisms by which pioglitazone improves skeletal muscle insulin sensitivity.
20
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Transcriptional dysregulation of skeletal muscle protein metabolism in streptozotocin-diabetic mice

67%
Wieteska-Skrzeczynska W., Grzelkowska-Kowalczyk K., Jank M., Maciejewski H.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 1
29-36
The purpose of the study was to evaluate potential changes in expression of genes involved in protein metabolism and myogenic differentiation markers in skeletal muscle of streptozotocin-diabetic mice. Microarray analysis revealed alterations in the expression of 84 gene transcripts in gastrocnemius muscle of diabetic mice. Regarding protein metabolism a marked downregulation in gene transcripts for: general transcription factor IIA1 (-1.88, P=0.016309), TATA box binding protein (-2.17, P=0.037373), eukaryotic translation initiation factor 4E nuclear import factor 1 (-1.61, P=0.037373), eukaryotic translation elongation factor Iß2 (-1.95, P=0.010406), ubiquitin-like 5 (-1.67, P=0.024975) and ubiquitin conjugating enzyme 7 interacting protein 1 (-1.68, P=0.016309) was observed. STZ-diabetes caused a drop in the expression of myogenin, whereas myostatin level was significantly elevated. In conclusion, 1) STZ-diabetes attenuates expression of gene transcripts involved in the process of transcription and translation, which may affect skeletal muscle protein synthesis and lead to nitrogen imbalance, 2) impaired expression of gene transcripts involved in the regulation and activity of the ubiquitin-proteasome pathway may contribute to attenuation of mechanisms eliminating damaged proteins in STZ-diabetes, 3) changes in the expression of key myogenic factors, manifested by a decrease in myogenin level and enhancement of myostatin expression may be one of the mechanisms limiting skeletal muscle growth and regeneration associated with diabetes.
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