Wyniki wyszukiwania

1

The influence of inflammatory process on prostaglandin F2alpha contractile activity in porcine uterus

100%

Kucharski J., Jaroszewski J., Jana B., Gorska J., Kozlowska A., Markiewicz W.

Journal of Animal and Feed Sciences

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2007

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tom 16

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nr 4

654-667

2

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

100%

Holma R., Salmenpera P., Virtanen I., Vapaatalo H., Korpela R.

Journal of Physiology and Pharmacology

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2007

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tom 58

|

nr 3

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was induced by administrating 4% dextran sulphate sodium (DSS, MW 45 000) in drinking water for 9 days. Montelukast (10 mg/kg/day) or vehicle was given by gastric gavage once daily simultaneously with DSS administration. A healthy control group receiving water as drinking fluid and vehicle by gastric gavage was included. Body weight loss, consistency of faeces (loose/diarrhoea) and occult blood in the faeces/ gross bleeding were assessed on days 6 - 9. After sacrifice, the following were assessed: colonic histology, the expression of inducible nitric oxide synthase, macrophage/monocyte marker ED1, cyclooxygenase-1 and cyclooxygenase-2, as well as the production of leukotriene B4 and E4, prostaglandin E2, its metabolite bicyclic-prostaglandin E2 and thromboxane B2 in the colonic tissue incubation in vitro. Rats receiving DSS exhibited bloody diarrhoea from day 6 onwards. Montelukast significantly reduced the occult blood in the faeces/ gross bleeding, maintained normal body weight gain and tended to decrease the ratio of leukotriene B4/ prostaglandin E2 production in the colon in vitro. The results indicate that montelukast has some potential to ameliorate mild experimental colitis induced by DSS.

3

Haemoglobin scavenger receptor: function in relation to disease

100%

Zuwala-Jagiello J.

Acta Biochimica Polonica

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2006

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tom 53

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nr 2

Highly efficient systems remove the toxic and proinflammatory haemoglobin from the circulation and local sites of tissue damage. Macrophages are major haemoglobin-clearing cells; CD163 was recently recognized as the specific haemoglobin scavenger receptor (HbSR). It is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection and inflammation. Haemoglobin functions as a double-edged sword. In moderate quantities and bound to haptoglobin, it forms a ligand for haemoglobin scavenger receptor CD163/HbSR, but when unleashed in large amounts, it can become toxic by mediating oxidative stress and inflammation. CD163/HbSR plays a crucial role in the control of inflammatory processes, probably in part through its effects on both ferritin induction and subsequent induction of antiinflammatory pathways through interleukin-10 and haem oxygenase. Besides the observation that the haemoglobin scavenger receptor provides a promising target for new treatment possibilities, it offers a novel view on the aetiology of diverse physiological as well as pathophysiological processes. In addition, monocyte CD163/HbSR and soluble CD163/HbSR are potential diagnostic tools in a variety of disease states, such as inflammation, atherosclerosis, transplant rejection, and carcinoma.

4

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

100%

Jablonska E., Marcinczyk M., Jablonski J.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

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nr 2

5

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke

84%

Cieslak M., Wojtczak A., Cieslak M.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Pro-inflammatory cytokines participate in the induction of ischemic stroke. So far, their participation in the cerebral ischemia was proven for the tumor necrosis factor TNF-α, interleukin-1 (IL-1), and interleukin-6 (IL-6). The release of the pro-inflammatory cytokines into the extracellular space causes the enlargement of the brain damage region, and consequently increases the neurological deficit and negatively affects the survival rate prognoses. That is confirmed by the increased concentration of pro-inflammatory cytokines in blood and the cerebrospinal fluid of patients with brain stroke, as well as by the research on the induced/experimental cerebral ischemia in animals. The pro-inflammatory cytokines participate in the migration of the reactive T lymphocytes to the regions of brain ischemia where they enhance the nerve tissue damage by down-regulation of microcirculation, induce the pro-thrombotic processes and release other neurotoxic cytokines. Also, in the early stage of cerebral ischemia, cytokines activate the axis hypothalamus-pituitary gland-adrenal cortex and increase the cortisol concentration in blood, what results in the decreased resistance to infectious diseases. Administration of the inhibitor of the interleukin-1 receptor (IL-1Ra) inhibits the inflammatory processes in the region of brain ischemia, and subsequently improves the prognosis for the size of the neurological deficit and the survival rate, as well as resistance to infectious diseases.

6

Testing and typing of eicosanoid-patterns

84%

Schafer D.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

|

nr 12

47-64

Eicosanoids are pleiotrope mediators with essential function in most biological processes. The network of inter- and intracellular signalling requires coordinated cellular information processing. The cross-talk is characterised by complex non-linear responses to combinations of different stimuli and cells, but little is known about the density of these interactions. Here I have analysed eicosanoid interactions carried out by functional eicosanoid testing and typing (FET) in leucocytes from healthy subjects and patients suffering from inflammatory diseases. The known eicosanoid pattern scoring was extended to metabolically linked prostaglandin E2 and peptido-leukotrienes pathways, both alone and in all pair wise combinations, for basal, maximal synthesis capacity, acetylsalicylic acid, and neuropeptide modification. Eicosanoids fluctuated over twenty minutes context-dependent dynamically, demanding further data integration. The integration suggested that many stimuli converge for quantitative discrimination applying a total eicosanoid pattern score (TEP). Varying cellular activities affect FET and thereby TEP. The non-additive metabolic interactions were consistent with known mechanisms of metabolic pathway cross-talk. FET-based modelling of eicosanoid circuits most suitably reflects the fundamental impact of eicosanoids in maintaining cellular integrity of organ and body function. This might improve our present understanding of complex cellular eicosanoid interactions of inflammatory diseases and might be applied for diagnostic considerations.

7

Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis

84%

Drzymala-Czyz S., Banasiewicz T., Tubacka M., Tarasiuk-Rusek A., Majewski P., Drews M., Walkowiak J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

|

nr 1

8

Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs

84%

Ojdana D., Safiejko K., Milewski R., Sacha P., Wieczorek P., Lipska A., Radziwon P., Dadan J., Tryniszewska E.

Folia Histochemica et Cytobiologica

|

2009

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tom 47

|

nr 3

9

Cough sensitivity in allergic rhinitis

84%

Pecova R., Vrlik M., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

|

nr 4

171-178

The objective of this study was to evaluate capsaicin cough sensitivity in pollen sensitive patients with allergic rhinitis at the time of grass pollen season and out of it. Cough reflex sensitivity was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Capsaicin aerosol in doubled concentrations (from 0.02 to 200 µmol) was inhaled by a single breath. Two groups of pollen sensitive rhinitis subjects and a group of healthy controls were studied. The C2 for the 23 pollen sensitive patients of the first group, studied out of pollen season (January-February), was 0.22 µmol/l (0.06-0.76) (geometric mean + 95% CI), which was substantially lower than the 4.29 µmol/l (2.54-7.26) in 24 healthy volunteers (P=0.0001). In another group of 15 pollen sensitive patients, C2 was 0.84 µmol/l (0.14-5.20) out of pollen season and 0.11 µmol/l (0.03-0.33) during the pollen season (May-June) (P=0.04). We conclude that pollen-sensitive subjects who suffer of seasonal allergic rhinitis have significantly greater capsaicin cough sensitivity, regardles of them being in or out of pollen season. Subclinical inflammatory changes in the lower airways are probably responsible for this effect.

10

Association between microvesicles bearing monomeric C-reactive protein and platelet reactivity. Relationship with low response to antiplatelet drugs?

84%

Siennicka A.

Journal of Physiology and Pharmacology

|

2021

|

tom 72

|

nr 1

11

MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1

84%

Meng L., Cao H., Wan C., Jiang L.

Folia Histochemica et Cytobiologica

|

2019

|

tom 57

|

nr 4

12

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Neopterin in patients with chronic kidney disease and patients with coronary artery disease

84%

Formanowicz D.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2012

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tom 93

|

nr 1

13

Viral strategies in modulation of NF-kappaB activity

84%

Lisowska K., Witkowski J. M.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 6

14

Proliferation activity and apoptosis in granulation tissue and cholesteatoma in middle ear reoperations

84%

Durko M., Kaczmarczyk D.

Folia Morphologica

|

2004

|

tom 63

|

nr 1

The aim of the study was to find out the potential prognostic value of proliferation activity and apoptosis in cholesteatoma and granulation tissue removed during middle ear reoperation in recurrent middle ear inflammation. Granulation tissues and recurrent cholesteatoma were analysed after being surgically removed from the middle ear in a group of 25 patients qualified for middle ear reoperation procedure. Paraffin sections were stained with haematoxylin and eosin according to Mallory’s method. Immunohistochemical reaction Anti-PCNA was performed. Apoptosis was evaluated using the TUNEL method. The percentage of PCNA-positive cells was 42–95% in the matrix of the cholesteatoma and 29–81% in the perimatrix. In the granulation tissue it was 35–75%. The percentage of apoptotic cells was 12–73% in the matrix of the cholesteatoma, 5–72% in the perimatrix and 1–65 % in the granulation tissue. The prognostic value of the parameters studied in the recurrent middle ear inflammatory process is questionable, probably due to the small number of cases under examination.

15

The level of vitamin D-binding protein (DBP) in serum of foals

67%

Madej J. P.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2008

|

tom 11

|

nr 4

16

Assessment of the influence of the inflammatory process on the activation of blood platelets and morphological parameters in patients with ulcerative colitis (colitis ulcerosa)

67%

Polinska B., Matowicka-Karna J., Kemona H.

Folia Histochemica et Cytobiologica

|

2011

|

tom 49

|

nr 1

17

Search of reference biomarkers reflecting orbital tissue remodeling in the course of Graves’ orbitopathy

67%

Pawlowski P., Poplawska I., Mysliwiec J., Dik W. A., Eckstein A., Berchner-Pfannschmidt U., Milewski R., Lawicki S., Dzieciol-Anikiej Z., Rejdak R., Reszec J.

Folia Histochemica et Cytobiologica

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2020

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tom 58

|

nr 1

18

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

67%

Cunha G. M. M., Silva V. M. A., Bessa K. D. G., Bitencourt M. A. O., Macedo U. B. O., Freire-Neto F. P., Martins R. R., Assis C. F., Lemos T. M. A. M., Almeida M. G., Freire A. C. G.

Acta Parasitologica

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2012

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tom 57

|

nr 2

Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden on carriers of schistosomiasis (n = 30) in the acute phase in comparison to healthy subjects (n = 30). The pro-oxidant parameter used was the colorimetric quantification of reactive substances to thiobarbituric acid, while the antioxidant markers used were blood content of reduced glutathione and determination of the activity of catalase. The worm burden was assessed by Kato-Katz method. The results pointed out that initially there was no difference in the catalase activity. However, there was a positive correlation between the increase in parasitic load and intensity of lipid peroxidation, and decrease in the content of reduced glutathione. Additionally, only the aspartate aminotransferase levels presented to be high, while there was a decrease in bilirubin level. Therefore, a possible association between the establishment of the oxidative stress in tissue and the parasitic load of Schistosoma mansoni is suggested.

19

Effects of cigarette smoke on the lung and systemic immunity

67%

Domagala-Kulawik J.

Journal of Physiology and Pharmacology. Supplement

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2008

|

tom 59

|

nr 6

19-34

20

Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions

67%

Javorkova N., Hajtmanova E., Kostkova L., Zamecnik L., Pecova R., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2006

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tom 57

|

nr 4

157-163

It is reasonable to suppose that airway mucosa can be damaged by irradiation applied to chest and neck regions. The inflammatory process is a consequence of an injury. Airway inflammation is one mechanism responsible for cough induction. So, one can suppose that radiotherapy (RT) focused on the patients' chest or neck may injure airway mucosa, which might change sensitivity of the nerve-endings mediating the cough reflex. The purpose of this study was to examine cough reflex sensitivity (CRS) in patients who underwent RT in the chest and neck regions. CRS test using capsaicin was performed in patients with breast cancer (Group A, n=19), and with lung or neck cancer in (Group B, n=14) who underwent RT. Capsaicin aerosol in doubled concentrations (0.49-1000 µM) was inhaled by a single breath. CRS was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Radiation doses ranged from 40 to 70 Gy. Capsaicin cough challenge was performed before and then in the 2nd and 5th week of RT. We observed a significantly reduced value of C2, i.e., increased cough reflex sensitivity, in Group B in the 2nd week of RT (P= 0.04). We conclude that CRS in the lung or neck cancer patients undergoing RT is significantly enhanced, which could result from injury to the nerve endings in airway mucosa.

Ograniczanie wyników

The influence of inflammatory process on prostaglandin F2alpha contractile activity in porcine uterus

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

Haemoglobin scavenger receptor: function in relation to disease

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke

Testing and typing of eicosanoid-patterns

Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis

Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs

Cough sensitivity in allergic rhinitis

Association between microvesicles bearing monomeric C-reactive protein and platelet reactivity. Relationship with low response to antiplatelet drugs?

MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1

Neopterin in patients with chronic kidney disease and patients with coronary artery disease

Viral strategies in modulation of NF-kappaB activity

Proliferation activity and apoptosis in granulation tissue and cholesteatoma in middle ear reoperations

The level of vitamin D-binding protein (DBP) in serum of foals

Assessment of the influence of the inflammatory process on the activation of blood platelets and morphological parameters in patients with ulcerative colitis (colitis ulcerosa)

Search of reference biomarkers reflecting orbital tissue remodeling in the course of Graves’ orbitopathy

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Effects of cigarette smoke on the lung and systemic immunity

Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions