Wyniki wyszukiwania

1

New target against inflammatory diseases: transglutaminase 2

100%

Kim S. Y.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 5

2

Efficacy of natural formulations in bovine mastitis pathology: alternative solution to antibiotic treatment

88%

Pasca C., Marghitas L. A., Dezmirean D. S., Matei I. A., Bonta V., Pasca I., Chirila F., Cimpean A., Fit N. I.

Journal of Veterinary Research

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2020

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tom 64

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nr 4

3

Insights into myeloid-derived suppressor cells in inflammatory diseases

75%

Kwak Y., Kim H.-E., Park S. G.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 4

4

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Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases

75%

Sobolewska-Wlodarczyk A., Wlodarczyk M., Banasik J., Gasiorowska A., Wisniewska-Jarosinska M., Fichna J.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 3

5

The pathogenesis and pathophysiology of acute pancreatitis

75%

Steer M. L.

Journal of Physiology and Pharmacology. Supplement

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1998

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tom 49

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nr 2

6

Diagnostic value of pancreatic elastase-1 in human acute pancreatitis

75%

Wereszczynska-Siemiatkowska U., Jedynak M., Mroczko B., Siemiatkowski A.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 3

7

Testing and typing of eicosanoid-patterns

63%

Schafer D.

Journal of Physiology and Pharmacology. Supplement

|

2006

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tom 57

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nr 12

47-64

Eicosanoids are pleiotrope mediators with essential function in most biological processes. The network of inter- and intracellular signalling requires coordinated cellular information processing. The cross-talk is characterised by complex non-linear responses to combinations of different stimuli and cells, but little is known about the density of these interactions. Here I have analysed eicosanoid interactions carried out by functional eicosanoid testing and typing (FET) in leucocytes from healthy subjects and patients suffering from inflammatory diseases. The known eicosanoid pattern scoring was extended to metabolically linked prostaglandin E2 and peptido-leukotrienes pathways, both alone and in all pair wise combinations, for basal, maximal synthesis capacity, acetylsalicylic acid, and neuropeptide modification. Eicosanoids fluctuated over twenty minutes context-dependent dynamically, demanding further data integration. The integration suggested that many stimuli converge for quantitative discrimination applying a total eicosanoid pattern score (TEP). Varying cellular activities affect FET and thereby TEP. The non-additive metabolic interactions were consistent with known mechanisms of metabolic pathway cross-talk. FET-based modelling of eicosanoid circuits most suitably reflects the fundamental impact of eicosanoids in maintaining cellular integrity of organ and body function. This might improve our present understanding of complex cellular eicosanoid interactions of inflammatory diseases and might be applied for diagnostic considerations.

8

RhTSG-6 inhibits IL-1beta-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells

63%

Pei S., Ying J., Zhand Y., Su L., Cheng S., Ruan D.

Folia Histochemica et Cytobiologica

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2020

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tom 58

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nr 3

9

Preliminary analysis of PON3 rs2375003 polymorphism in Pakistani patients with coronary artery disease

63%

Sameem M., Arshad M.

Folia Biologica

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2019

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tom 67

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nr 3

10

An age-related decrease in factor V Leiden frequency among Polish subjects

63%

Adler G., Parczewski M., Czerska E., Loniewska B., Kaczmarczyk M., Gumprecht J., Grzeszczak W., Szybinska A., Mossakowska M., Ciechanowicz A.

Journal of Applied Genetics

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2010

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tom 51

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nr 3

Factor V Leiden (G1691A FV mutation) is a widely acknowledged risk factor of deep vein thrombosis, including pulmonary embolism as the most serious complication. However, its high prevalence of ~5% in the Caucasian population might be related to an unknown evolutionary advantage. It might exert a beneficial effect on the carrier, e.g. protecting women from excessive bleeding during labour or allowing increased survival in severe sepsis or with other inflammatory diseases. The aim of our study was to verify or contradict the hypothesis of a favourable association between the A allele (A1691) and longevity in the Polish population. For this purpose, the G1691A mutation was analyzed by PCR-RFLP in 1016 Poles: 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (age ≥ 95 years: 343 women and 89 men). Frequencies of G1691A carriers and the A1691 allele in long-lived individuals (0.2% and 0.1%, respectively) were significantly lower than in neonates (4.2% and 2.2%, respectively) and adults (3.3% and 1.6%). The frequency of the G1691A factor V Leiden mutation decreased with age, which indicates a shorter survival time among A1691 allele carriers in the Polish population.

11

Humoral and cellular autoreactivity to epidermal proteins in atopic dermatitis

63%

Navarrete-Dechent C., Perez-Mateluna G., Silva-Valenzuela S., Vera-Kellet C., Borzutzky A.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

|

nr 6

12

Intraepidermal nerve fiber density in vulvar lichen sclerosus and normal vulvar tissues

63%

Milian-Ciesielska K., Chmura L., Dyduch G., Jagers C., Radwanska E., Adamek D.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 3

13

Quercetin: health benefits with relevance to TNF-alpha-linked inflammatory diseases

63%

Harrison A. P., Cooper R. G.

Journal of Pre-Clinical and Clinical Research

|

2008

|

tom 02

|

nr 2

14

Functional eicosanoid test and typing [FET] of peripheral blood cells in eicosanoid related diseases

63%

Schafer D., Baenkler H. W.

Journal of Physiology and Pharmacology. Supplement

|

2005

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tom 56

|

nr 5

103-118

Monitoring of eicosanoid synthesis in peripheral blood cells has significant potential for improving the diagnosis and therapy of many human diseases. The quantitative relation between concentrations of prostaglandins and leukotrienes is central to the physiologic function of the eicosanoid network. Here we show that this regulation, which we call the functional eicosanoid typing (FET), fluctuates dynamically in individual living blood cells from patients, thereby limiting the accuracy with which concentration circuits of eicosanoids can transfer metabolic information. Using living cells in functional cell testing, we characterised the eicosanoid pattern score (EPS). A novel technique based on binomial errors on lipid mediator partitioning enabled calibration of in vivo biochemical parameters in molecular units. We found that eicosanoid production rates fluctuate over a time scale of about twenty minutes, while intrinsic noise decays rapidly. Thus, biochemical eicosanoid parameters, noise, and slowly varying cellular states together determine the effective FET. These results can form a basis for quantitative modelling of natural eicosanoid circuits in diagnosis of eicosanoid related diseases and design of synthetic ones for the prediction other diseases.

15

The effects of adjuvant arthritis on the myometrial adrenergic functions in the nonpregnant and the late-pregnant rat

63%

Csik G., Spiegl G., Minorics R., Falkay G., Zupko I.

Journal of Physiology and Pharmacology

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2010

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tom 61

|

nr 5

16

Impact of different treatment of whole-body cryotherapy on circulatory parameters

63%

Bonomi F. G., De Nardi M., Fappani A., Zani V., Banfi G.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

|

nr 2

17

The mediсo-organizational model of protection of reproductive health of women with inflammatory diseases of generative organs

63%

Naumov I., Tishchenko Y., Aleksandrovich A.

Health Problems of Civilization

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2014

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tom 08

|

nr 3

The work purpose: To develop, scientifically to prove and introduce medical-organizational model of protection of reproductive health of patients with inflammatory diseases of genitals. Materials and methods. The female population of fertile age with inflammatory diseases of the genitals, living in the Grodno area per 1954–2008 is studied. The system approach is used, following methods were applied: sanitary-statistical, economic-mathematical, expert estimations, sociological, historical, organizational experiment, modelling and forecasting. Results. On the basis of the carried out complex socially-hygienic research including studying of volumes and quality of medical aid, security of obstetric-gynecologic service material, financial and personnel resources, introductions of new organizational, medical and information technologies, studying of the reproductive equipments of women of fertile age and prospects of realisation by them of reproductive function, and also an expert estimation of the importance of the problems bound to disturbances in reproductive system, develop medical-organizational model of protection of reproductive health of women with inflammatory diseases of the genitals, based on state policy realisation in public health services. Model actions are realised in three stages: pregravidal improvement; medical maintenance in pregnancy; The organisation of medical aid to women in childbirth and newborns, and also aftertreatment after a failure of pregnancy and sorts.

18

NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system

63%

Antosz H., Osiak M.

Acta Biochimica Polonica

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2013

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tom 60

|

nr 3

NOD-like proteins (NLR) are a specialized group of intracellular receptors, which constitute an essential component of the host innate immune system. They were discovered more than a decade ago, but research on this particular class of microbial detectors is still ongoing to allow for a better understanding of the mechanisms, recognition of microorganisms, transmission of signals, and carrying out the activation of inflammatory signaling pathways. In this review, we discuss the construction of NOD1 and NOD2 receptors, their functions, and significance in the pathogenesis of inflammatory diseases in humans.

19

CSF-1 as a regulator of macrophage activation and immune responses

63%

Sweet M. J., Hume D. A.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 3

20

Helicobacter pylori [Hp] infection and the morphological picture of gastric mucosa in connective tissue inflammatory diseases

63%

Poniewierka E., Rzeszutko M., Misterska-Skora M.

Journal of Physiology and Pharmacology. Supplement

|

1997

|

tom 48

|

nr 1

Ograniczanie wyników

New target against inflammatory diseases: transglutaminase 2

Efficacy of natural formulations in bovine mastitis pathology: alternative solution to antibiotic treatment

Insights into myeloid-derived suppressor cells in inflammatory diseases

Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases

The pathogenesis and pathophysiology of acute pancreatitis

Diagnostic value of pancreatic elastase-1 in human acute pancreatitis

Testing and typing of eicosanoid-patterns

RhTSG-6 inhibits IL-1beta-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells