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1

Influence of hyperthyroidism on acceptor activity of tRNA in some rabbit tissue

100%
Szymonik-Lesiuk S., Pasternak K., Brzuszkiewicz-Zarnowska H., Borkowski T.
Applied Biology Communications. Lublin Scientific Center
|
1993
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tom 03
|
nr 1-2
2
Content available remote

Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications

86%
Czarnywojtek A., Zgorzalewicz-Stachowiak M., Czarnocka B., Sawicka-Gutaj N., Gut P., Krela-Kazmierczak I., Ruchala M.
Journal of Physiology and Pharmacology
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2020
|
tom 71
|
nr 2
3

Activity of aminoacyl-tRNA synthetases in experimental hyperthyroidism in muscle tissues of the rabbit

86%
Pasternak K., Szymonik-Lesiuk S., Brzuszkiewicz-Zarnowska H., Borkowski T.
Acta Biochimica Polonica
|
1994
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tom 41
|
nr 1
In cardial and femoral muscles of rabbits specific activities of aminoacyl-tRNA synthetases for twenty amino acids were generally similar, namely the activities towards amino acids and their amides, leucine, isoleucine, histidine, tyrosine, proline and serine were considerably lower than towards the remaining amino acids. Specific activities of most aminoacyl-tRNA synthetases were higher in hyper­thyroidism than in euthyreosis, and were higher in femoral muscle than in heart The response to thyroxine treatment of individual aminoacyl-tRNA synthetases in both kinds of muscles varied with respect to most of the amino acids.
4

Mitochondrial tRNA in hyperthyroidism

86%
Pasternak K., Szymonik-Lesiuk S., Brzuszkiewicz-Zarnowska H., Borkowski T.
Acta Biochimica Polonica
|
1995
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tom 42
|
nr 2
The mitochondrial tRNA were prepared from liver and brain tissues of thyroxinized and control rabbits. The presence of tRNA for twenty amino acids both in liver and brain mitochondria was revealed. The quantity of radioactive amino acids bound to the mitochondrial tRNA was higher in hyperthyreosis than in control animals but considerable differences between the brain and liver tissues were observed.
5
Content available remote

Vasopressin and oxytocin release and the thyroid function

86%
Ciosek J., Drobnik J.
Journal of Physiology and Pharmacology
|
2004
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tom 55
|
nr 2
The aim of the present investigations was to examine the effects of the states of hypothyroidism or hyperthyroidism on vasopressin (AVP) and oxytocin (OT) release under conditions of equilibrated water metabolism as well as of osmotic stimulation, brought about by the dehydration or hypertonic saline administration. The euhydrated and simultaneously hypothyroid rats showed decreased hypothalamic AVP and OT content and somewhat higher but not significant neurohypophysial AVP content. In these animals the raised OT (but not AVP) plasma level has been observed. In hyperthyroid rats drinking tap water ad libitum the neurohypophysial AVP and OT content significantly diminished; plasma OT concentration (but not AVP) was then elevated. The state of osmotic stimulation was the reason of different response of the hypothalamo-neurohypohysial system function in hypo- or hyperthyroid rats. Significant decreases of neurohypophysial AVP and OT content were found in both hypothyroid dehydrated as well as hypothyroid hypertonic saline-treatment rats as compared with hypothyroid euhydrated ones. On the contrary, in the state of hyperthyroidism AVP content in the neurohypophysis distinctly raised in dehydrated and salt-loaded rats; in these last neurohypophysial OT content increased as well. Plasma OT (but not AVP) distinctly diminished in hyperthyroid and simultaneously dehydrated or hypertonic saline injected rats in relation to hyperthyroid control subgroup. Data from the present study suggest that: 1) altered thyroid gland function affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in the state of equilibrated water metabolism; 2) the state of hypo- or hyperthyroidism modifies the response of AVP-ergic and OT-ergic neurons upon the osmoreceptors/osmodetectors stimulation. It may be sypposed that OT-ergic neurons display greater than AVP-ergic neurons sensitivity upon the thyroid hormone influence.
6

Treatment of Graves’ disease with methimazole in children alters the proliferation of Treg cells and CD3+ T lymphocytes

72%
Klatka M., Kaszubowska L., Grywalska E., Wasiak M., Szewczyk L., Foerster J., Cyman M., Rolinski J.
Folia Histochemica et Cytobiologica
|
2014
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tom 52
|
nr 1
7

Structural, functional, and lectin histochemical characteristics of rat ovaries and endometrium in experimental hyper- and hypothyroidism

72%
Lutsyk A., Sogomonian E.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 3
8

Effects of thyroxine treatment during lactation on the testicular function of rats across different ages

72%
Dahmani-Said S., Hamouli-Said Z., Kamel A., Hadj-Bekkouche F.
Folia Histochemica et Cytobiologica
|
2013
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tom 51
|
nr 2
9

Thyroid hormone dysfunctions affect the structure of rat thoracic aorta: a histological and morphometric study

72%
Zaki S. M., Youssef M. F.
Folia Morphologica
|
2013
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tom 72
|
nr 4
Background: There are limited data about the influence of hypothyroidism and hyperthyroidism on the connective tissue component and smooth muscle cells of the thoracic aorta. The aim was to study the histological changes of the wall of the thoracic aorta in the hypothyroid and hyperthyroid rats. Morphometric measurements were also done. Materials and methods: Thirty adult rats were used. They were divided into control, hyperthyroid, and hypothyroid groups. Each group consisted of 10 rats. The animals were sacrificed at the end of 8 weeks and the descending aorta was excised. Sections were stained with haematoxylin and eosin, orcein and Masson’s trichrome stains. The morphometric measurement included: number of smooth muscle cell nuclei, number of the elastic lamellae, thickness of the tunica media, elastic fibre optic density, and relative collagen area. Results: Atheromatous plagues had been observed in the hyperthyroid group. Thinning and rupture of the elastic lamellae had been observed in the hypothyroid group; these were accompanied with intimal ulceration and aortic dissection. The average number of smooth muscle cell nuclei in the hyperthyroid group had doubled and tripled compared to their fellows in the control and hypothyroid groups, respectively. The thickness of the tunica media increased in the hyperthyroid and hypothyroid groups by 75% and 35%. In addition, the relative collagen area increased in the previously mentioned groups by 142% and 120%, respectively. On the other hand, the mean elastic fibre optic density decreased in both groups by 30%. Conclusions: Structure wall affections of the intima and media of the descending aorta were associated with the thyroid hormone dysfunctions. These changes were more severe in the hypothyroid group. (Folia Morphol 2013; 72, 4: 333–339)
10

Thyroid hormones concentrations and ECG picture in the dog

72%
Paslawska U., Noszczyk-Nowak A., Kungl K., Bioly K., Popiel J., Nicpon J.
Polish Journal of Veterinary Sciences
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2006
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tom 09
|
nr 4
Disorders of the thyroid gland activity are the most commonly encountered disturbances of endocrine origin in the dog. (Hypoorlhyperthyroidism may disturb the function of the cardiovascular system and cause arrhythmias. The aim of this study was to evaluate the influence of thyroid gland activity on electrocardiogram (ECG) picture in the dog by comparing ECG curves of healthy dogs, dogs with hypothyroidism and dogs with cardiac insufficiency caused by endocardiosis of the mitral valve. The study was performed on 38 dogs, patients of the Department of Internal and Parasitic Diseases with Clinic for Horses, Dogs and Cats in Wroclaw. The animals were assigned to 3 groups: Group I - control group, 13 clinically healthy dogs; Group II - 14 dogs with diagnosed cardiac insufficiency caused by endocardiosis of the mitral valve; Group III - 11 dogs with hypothyroidism. Clinical examination of the animals was conducted according to the following pattern: anamnesis, general clinical examination, cardiological examination (ECG, USG of the heart) and laboratory analysis (triacylglycerydes, cholesterol, T3, T4, FT4). In this study, the significant influence of thyroid gland activity on ECG picture of the evaluated dogs was found. In the dogs with hypothyroidism a decrease in the sino-atrial node activity was observed, which led to decreased heart rate. In dogs with hypothyroidism, the innerheart conduction was reduced, which was demonstrated by prolongation of the P wave, QRS complex and the QT interval.
11

Arrhythmias in programmed electrical stimulation in the course of experimentally induced hyperthyroidism in an animal model

72%
Noszczyk-Nowak A., Gajek J., Paslawska U., Skrzypczak P., Zysko D., Nicpon J.
Bulletin of the Veterinary Institute in Puławy
|
2008
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tom 52
|
nr 1
To determine changes in physiological parameters of the myocardium in experimentally induced hyperthyreosis in an animal model, the occurrence and type of arrhythmias triggered during programmed electrical stimulation and changes in electrophysiological parameters of ventricular cardiomyocytes with hypertrophy due to hyperthyreosis were investigated. Hyperthyreosis was induced experimentally in five pigs, which were orally administered L-thyroxine at a dose of 20 µg/kg. Five untreated pigs served as the control. Programmed electrical stimulation was performed before administration of L-thyroxine (EPS 1), four (EPS 2) and eight (EPS 3) weeks after the onset of thyroxine administration, and four weeks after drug withdrawal (EPS 4). After the last stimulation, the animals were sacrificed and necropsied, with particular regard to heart autopsy. During the EPS 2, VERP was decreased in the group treated with the hormone (P<0.05). The mean values of AERP and AVNERP in the group were decreased as well. Atrial flutter and atrial fibrillation were induced during stimulation of the experimental group. In the other pigs of the experimental group, singular and paired ventricular extrasystolic were observed. In the EPS 3, AERP and AVNERP were statistically shorter in pigs with hyperthyreosis. A significant difference in Wenckebach CL between the control and experimental groups were observed. SNRT was shorter in the group with hyperthyreosis. In all pigs with hyperthyreosis, atrial fibrillation was induced. In one pig, non-sustained ventricular tachycardia was observed. During EPS 4, AERP remained shorter in group with hyperthyreosis. In two pigs of the group, atrial fibrillation was induced during pacing, and in two pigs, ventricular fibrillation was observed. The assessment of the heart's weight revealed a significant increase in its mass in pigs with hyperthyreosis. An increase in the thickness of the right and left ventricle free walls (P<0.01) and interventricular septum (P<0.01) was found in pigs with hyperthyreosis. At the same time, the inner diameter of the left ventricle was significantly smaller in this group (P<0.01) due to a concentric hypertrophy of the ventricle. In view of these findings, experimental hyperthyreosis caused shortening of refractory periods of different parts of the conducting system and enhanced susceptibility to supraventricular and ventricular arrhythmias, both spontaneous and induced during electrical stimulation. The mechanism of these arrhythmias can differ as a consequence of the hypertrophy of the left ventricle.
12

Estimation of gastric ghrelin-positive cells activity in hyperthyroid rats

58%
Dadan J., Zbucki R. L., Sawicki B., Winnicka M. M.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 4
511-517
13
Content available remote

Effects of hyperthyroidism on lipid content and composition in oxidative and glycolytic muscles in rats

58%
Miklosz A., Chabowski A., Zendzian-Piotrowska M., Gorski J.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 4
14

Serum glycoproteins in patients with hypo- and hyperthyroidism

58%
Kucharz E. J., Olczyk K., Glowacki A., Duraj-Kassem M.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 1
15

Dermatozy endokrynne psów - wybrane jednostki najczęściej spotykane w praktyce klinicznej

44%
Debmele V.
Weterynaria w Praktyce
|
2020
|
tom 17
|
nr 01-02
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