Wyniki wyszukiwania - AGRO

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Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats

100%

Sipola M., Finckenberg P., Santisteban J., Korpela R., Vapaatalo H., Nurminen M. L.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 4,2

Effect of long-term intake of isoleucine-proline-proline (IPP) and valine-proline-- proline (VPP), or a sour milk product containing these peptides on development of hypertension was investigated in spontaneously hypertensive rats (SHR). Six-week-old SHR were given: 1) water (control group), 2) IPP and VPP dissolved in water (peptide group) or 3) sour milk containing IPP and VPP (sour milk group) for 12 weeks. Systolic blood pressure (SBP) was measured by tail-cuff method. Development of hypertension was attenuated in the groups receiving tripeptides or sour milk as compared to the control group. At the end of treatment period, SBP was 176 ± 1 mmHg in sour milk group, 181 ± 2 mmHg in peptide group, and 193 ± 1 mmHg in control group (P < 0.001). After treatment withdrawal, SBP rose gradually reaching the level of control group within four weeks’ follow-up. In functional bioassay of ACE inhibitory activity, effect of the tripeptides on angiotensin I or angiotensin II-induced contraction in rat mesenteric arteries was evaluated. IPP inhibited the angiotensin I -induced contraction, whereas the angiotensin II-induced contraction remained unaltered. In conclusion, long-term intake of IPP and VPP, or a sour milk containing these tripeptides attenuated the development of hypertension in SHR. One possible mechanism underlying this effect is ACE inhibition.

2

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Effect of Endothelin-3 on blood pressure in conscious spontaneously hypertensive [SHR] and DOCA-salt hypertensive rats

100%

Januszewicz A., Lon S., Lapinski M., Stys A.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 1

3

Evaluation of mineral status in hypertensive patients undergoing pharmacotherapy

86%

Marcinek K., Suliburska J., Krejpcio Z., Bogdanski P.

Roczniki Państwowego Zakładu Higieny

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2015

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tom 66

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nr 1

Background. The widespread and increasing occurrence of obesity, hypertension and associated disease has necessitated serial testing in order that risks of contracting such conditions become minimised through appropriate therapy and prevention. Many studies report that nutritional factors significantly affect the aetiology of hypertension and obesity that include mineral uptake. There are only a few studies however which are focused on the body’s changing mineral content during pharmaco-therapeutic treatment. Objectives. To determine concentrations of minerals in the hair and urine of hypertensive patients in conjunction with assessing their nutrition. Material and Methods. Subjects were 17 patients presenting with essential hypertension and 18 healthy controls. Atomic absorption spectrometry (AAS) was used to measure Mg, Ca, Fe, Zn and Cu in the hair and urine on a Zeiss AAS-3 instrument. Dietary mineral intakes were assessed by interview over 24 hours prior to the analysis. Results. The hypertensive group had significantly lower urine concentrations of Ca and Mg as well as Mg and Zn in hair. Urinary zinc excretion was significantly increased in this group compared to controls, but dietary intakes of Cu were reduced. The dietary mineral intakes were found to be unrelated to the concentrations of such minerals in the hair and urine. Conclusions. Compared to controls, excretion of Ca and Mg were reduced in hypertensive subjects, whereas Zn excretion was higher, and Mg and Zn were relatively low in the hair. Daily dietary intakes of Cu were also reduced in the hypertensive.

4

Uric acid in hypertension - a marker of cardiovascular risk related to body composition

86%

Palkowska-Gozdzik E., Krzesinski P., Piotrowicz K., Stanczyk A., Gielerak G., Piechota W., Skrobowski A.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 2

Introduction. Elevated uric acid (UA) is associated with arterial hypertension (AH), obesity, dyslipidemia and insulin resistance. However, its association with body components has not been previously investigated. Objective. The aim of this study was to evaluate the relationship between UA and cardiovascular risk factors, anthropometric parameters and body composition in patients with AH. Materials and method. In 138 patients with AH the following parameters were evaluated: UA, low and high density lipoproteins (LDL-C, HDL-C), triglycerides (TG), fasting glucose (FG), creatinine; body mass index (BMI), waist circumference (WC), fat mass (FM), fat free mass (FFM) and total body water (TBW). Results. Positive correlations were shown between UA and LDL-C (p=0.041), TG (p<0.001), FG (p=0.025) and creatinine (p<0.001) and negative between UA and HDL-C (p<0.001). Significant associations between UA and anthropometric parameters and body components, such as WC (p<0.001), BMI (p<0.001), FFM (p<0.001) and TBW (p<0.001), were also observed. In the multiple regression model, independent predictors of UA concentration were serum creatinine and TBW (R2=0.45; p<0.001). Conclusions. In patients with AH, uric acid was significantly related to cardiovascular risk factors, including obesity. However, the main anthropometric determinant of plasma UA concentration is FFM. The consideration of body composition in the interpretation of UA concentration appears to be justified, but the verification of this hypothesis requires further studies.

5

Acceptance of illness and satisfaction with life among patients with arterial hypertension

86%

Baczewska B., Kropornicka B., Sepiolo J., Krzyzanowska E., Olszak C., Szymczuk E., Daniluk J.

Health Problems of Civilization

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2015

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tom 09

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nr 3

The aim of this study was to determine and compare the degree of acceptance of the disease and the level of satisfaction with life among people with diagnosed hypertension. The research was carried out by means of a diagnostic survey. The study used the scale of AIS - Approval Illness Scale (Acceptance of Illness Scale). For measuring life satisfaction ladder Cantrill was used. It assessed satisfaction with life on a scale from 0 to 10. The study was conducted in June 2014 among the residents of Lubelskie and Świętokrzyskie voivodships. The study was anonymous. The approval of the Bioethics Committee at the Medical University of Lublin (KE-0254/176/2014) was received for carrying out the tests. The study included patients diagnosed with hypertension – total of 154 people. The study has shown the average degree of acceptance of the disease. Illness and healing therapy did not impact negatively the functioning of most respondents. The respondents described their adaptation to the limitations imposed by the disease in different degrees. The vast majority of respondents did not have any problems arising from the disease and did not abandon their favorite activities. Every third respondent with hypertension felt as being a defective person and dependent on other people. The relation between satisfaction with their own lives, and the level of acceptance of the disease was concluded in that study. The higher the degree of satisfaction with patients’ lives, the higher the acceptance of illness. Studies have shown positive correlations between gender, age, place of residence, duration of illness and education, and acceptance of the disease. In contrast, there was no statistically significant association between marital status and the test subject.

6

Comorbidities as an element of multidimensional prognostic assessment of patients with chronic obstructive pulmonary disease

86%

Grabicki M., Parysek H., Batura-Gabryel H., Brodnicka I.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

297-301

7

Determination of hippuric acid by RP-HPLC using two different analytical columns - a short report

86%

Pegg R. B., Rybarczyk A., Amarowicz R.

Polish Journal of Food and Nutrition Sciences

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2007

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tom 57

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nr 4

447-450

Reversed-phase HPLC of liberated hippuric acid (HA) from an ACE assay in the presence of ACE inhibitory peptides derived from a crackling hydrolysate was conducted. The efficacies of two different analytical HPLC columns using identical mobile phases with an isocratic system were tested. Chromatograms revealed that the shorter C8 column (4.6 × 150 mm, 5 μm) was just as efficient as the longer C18 column (4.6 × 250 mm, 5 μm) in resolving liberated HA, but achieved this in a much shorter time (i.e., 3.67 cf 12.52 min). The presence of the crackling hydrolysate exhibited ACE-inhibiting activity by retarding the liberation of HA from the substrate hippuryl-L-histydyl-L-leucine (HHL) in a dose-dependent manner, and did not interfere with the chromatography. Hence, a quick reliable analytical methodology is at hand for the in vitro examination of various “bioactive peptide concoctions” for possible use in the development of functional foods.

8

Upregulation of GRP78 and caspase-12 in diastolic failing heart

86%

Sun Y., Liu G., Song T., Liu F., Kang W., Zhang Y., Ge Z.

Acta Biochimica Polonica

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2008

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tom 55

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nr 3

511-516

Background: The endoplasmic reticulum (ER) fulfills multiple cellular functions. Various stimuli can potentially cause ER stress (ERS). ERS is one of the intrinsic apoptosis pathways and apoptosis plays a critical role in hypertension. Glucose regulated protein 78 (GRP78) has been widely used as a marker for ERS and caspase-12 mediated apoptosis was a specific apoptotic pathway of ER. The expression of GRP78 and caspase-12 remains poorly understood in the diastolic heart failure resulting from hypertension. Methods: We used spontaneously hypertensive rats (SHRs) to establish a model of diastolic heart failure, and performed immunohistochemistry, Western blot, and real-time PCR to analyze GRP78 and caspase-12. Results: We found that GRP78 and caspase-12 had enhanced expression at protein and mRNA levels. Conclusions: These results suggest that GRP78 and caspase-12 were upregulated in cardiomyocytes and ERS can contribute to cardiac myocyte apoptosis in the diastolic heart failure resulting from hypertension.

9

New aspects in the treatment of hypertension

86%

Maretskyi V.

Health Problems of Civilization

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2015

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tom 09

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nr 3

Hypertension is currently the leading cause of cardiovascular complications (heart attack, stroke) and the resulting deaths of patients. Reduced morbidity and mortality from cardiovascular complications is the main goal of treating patients suffering from high blood pressure (BP). To achieve target BP levels in the arsenal of physicians are five major classes of antihypertensive drugs: angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, β-blockers, diuretics. The choice of antihypertensive drug in concrete clinical situation often complicated and determined by complex factors. Among these presence of risk factors; target organ damage; associated clinical conditions, metabolic syndrome, diabetes, comorbidities; possible individual patient response to antihypertensive drugs of different classes in history; the likelihood of drug interactions; socio-economic factors, including the cost of treatment of hypertension. Promising is the use of angiotensin II receptor blockers - drugs with pleiotropic pharmacological properties that have a multicomponent antihypertensive efficacy, good tolerability, diverse organoprotection that are safe, able to enhance remote prognosis for patients with hypertension. Azilsartan medoxomil is a competitive reversible angiotensin II type 1 receptor antagonist. Azilsartan developing hypotensive effect faster, prolonged and pronounced compared to other sartans (valsartan, candesartan and olmesartan). In addition to antihypertensive action azilsartan medoxomil shows a number of additional pleiotropic effects. These include antithrombotic, antiproliferative and antyfibrotic action. It demonstrates the improvement in glucose tolerance and tissue insulin sensitivity, improves endothelial function, reduces the progression of albuminuria, proteinuria.

10

Fatty acid pattern and lipid and mineral component concentration in serum in essential hypertension

86%

Wartanowicz M., Ziemlanski S., Czarkowski M., Chodakowska J., Chojnowski K.

Żywienie Człowieka i Metabolizm

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1991

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tom 18

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nr 3

The composition of fatty acids of serum lipids, the levels of serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides), mineral components (sodium, potassium, calcium, magnesium) and antioxidant vitamins (ascorbic acid, retinol, carotene, tocopherol) were determined in men aged about 25 years. The serum of hypertensive subjects (systolic blood pressure > 140 mmHg or more) contained, in relation to normotensive subjects, significantly less linolic acid, docosahexaenoic acid and oleic acid, but the total level of unsaturated fatty acids was not different between these two groups. No differences were found in the serum levels of the determined mineral components between normotensive and hypertensive men.

11

Endothelial nitric oxide synthase gene polymorphism and hypertension

86%

Wlodarczyk M., Nowicka G., Jarosz A.

Żywienie Człowieka i Metabolizm

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2011

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tom 38

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nr 2

Endothelial nitric oxide synthase (eNOS) is known as mediator of endothelium-dependent vasodilatation. The gene encoding this enzyme is regarded as one of the candidate for risk of developing hypertension. The aim of our study was to investigate whether polymorphism in intron 4 (4a/b) of eNOS gene is associated with hypertension. Gene variants were determined by PCR method among 82 healthy, normotensive and 62 hypertensive individuals. In the group of patients with hypertension as compared to the controls higher frequency of 4a4a+4a4b genotypes (45.2% vs 23.5%) and lower frequency of 4b4b genotype (54.8% vs 76.5%) was observed. The data indicate a significant association between presence of 4a allele of eNOS gene and hypertension in studied population.

12

Prevalence of hypertension in a sample of Polish population - baseline assessment from the prospective cohort ‘PONS’ study

86%

Szuba A., Martynowicz H., Zatonska K., Ilow R., Regulska-Ilow B., Rozanska D., Wolyniec M., Einhorn J., Vatten L., Asvold B. O., Manczuk M., Zatonski W. A.

Annals of Agricultural and Environmental Medicine

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2011

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tom 18

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nr 2

13

Cognitive consequences of metabolic disorders

86%

Lopuszanska U., Cholewa K., Kozyra M.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

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nr 4

14

An analysis of stress coping in pregnant women with hypertension

86%

Kraczkowski J., Szymona K., Smolen A., Robak J., Semczuk M.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

Pregnancy-induced hypertension is a life threatening complication of pregnancy, both for a woman and for a child. The study aimed to evaluate models of coping with stress in a group of women with pregnancy hypertension. 30 women with pregnancy-induced hypertension were enrolled in the study. Authors made use of the Cattell Personality Factors test by K. Hirszl that assesses personality profiles and The Coping Inventory for Stressful Situations (CISS) by Endler&Parker in a Polish modification by P. Szczepaniak, K. Wrześniewski and J. Strelau. A high level of inner tension characterizes women with pregnancy-induced hypertension. Together with anxiety increase, escape from both contacts and discussing problems is observed in these women. Such situation may lead to secondary emotional agitation with a negative impact on both mother's and child's health state.

15

Health-related effects of conjugated fatty acids

86%

Kostogrys R. B., Franczyk-Zarow M.

Polish Journal of Food and Nutrition Sciences

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2011

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tom 61

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nr Suppl.1

16

Ghrelin-immunoreactive cells in the gastrointestinal tract of hypertensive rats

86%

Janiuk I., Kaleczyc J., Kasacka I.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 4

17

Association of ACE DD genotype with Hypertension among the tribal populations of South India

86%

Paramasivam R., Nandakumar R., Arumugam D., Krishnan P.

International Letters of Natural Sciences

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2016

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tom 52

The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0 .705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

18

Effects of moderate physical training on blood pressure variability and hemodynamic pattern in mildly hypertensive subjects

86%

Izdebska E., Cybulska I., Izdebski J., Makowiecka-Ciesla M., Trzebski A.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 4

The objective of our study was to compare the cardiovascular effects of moderate exercise training in heathy young (NTS, n=18, 22.9±0.44 years) and in hypertensive human subjects (HTS, n=30, 23±1.1). The VO2max did not significantly differ between groups. HTS of systolic blood pressure (SBP) 148±3.6 mmHg and diastolic blood pressure(DBP) 88±2.2mmHg, and NTS of SBP: 128.8 ± 4 mmHg and DBP: 72 ± 2.9 mmHg were submitted to moderate dynamic exercise training, at about 50% VO2max 3 times per week for one hour, over 3 months. VO2max was measured by Astrand's test. Arterial blood pressure was measured with Finapres technique, the stroke volume, cardiac output and arm blood flow were assessed by impedance reography. Variability of SBP and pulse interval values (PI) were estimated by computing the variance and power spectra according to FFT algorithm. After training period significant improvements in VO2max were observed in NTS- by 1.92 ±0.76 and in HTS by 3±0.68 ml/kg/min). In HTS significantly decreased: SBP by 19 ±2.9 mmHg, in DBP by 10.7±2 mmHg total peripheral resistance (TPR) by 0.28 ±0.05 TPR units. The pretraining value of low frequency component power spectra SBP (LFSBP) was significantly greater in HTS, compared to NTS. PI variance was lower in HTS, compared to NTS. After physical training, in HTS PI variance increased suggesting a decrease in frequency modulated sympathetic activity and increase in vagal modulation of heart rate in mild hypertension. A major finding of the study is the significant decrease of resting low frequency component SBP power spectrum after training in HTS. The value of LFSBP in trained hypertensive subjects normalized to the resting level of LFSBP in NTS. Our findings suggest that antihypertensive hemodynamic effects of moderate dynamic physical training are associated with readjustment of the autonomic cardiovascular control system.

19

The selected pathophysiological aspects of PPARs activation

86%

Kiec-Wilk B., Dembinska-Kiec A., Olszanecka A., Bodzioch M., Kawecka-Jaszcz K.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 2

Peroxisome proliferator activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, ß/ and , encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as anti-hypertensive functions. In hypertension-induced cardiac hypertrophy, both PPARalpha and PPAR activation reveal cardio-protective effect. Despite these beneficial functions, several recent experimental reports point to the possibille unfavorable effects of PPARs activation in lipid metabolism (lipotoxicity) in cardiomyocytes, which can lead to pathologic cardiac hypertrophy in such diseases as diabetes type 2, metabolic syndrome or obesity. This paper reviews evidences and hypotheses about the new pathophysiological aspects of PPARs activation.

20

Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats

86%

Jin L., Beswick R. A., Yamamoto T., Palmer T., Taylor T. A., Pollock J. S., Pollock D. M., Brands M. W., Webb R. C.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

Hypertension is associated with increased reactive oxygen species (ROS). Renal ROS production and their effects on renal function have never been investigated in mineralocorticoid hypertensive rats. In this study we hypothesized that increased ROS production in kidneys from deoxycorticosterone (DOCA)-salt rats contributes to adverse renal morphological changes and impaired renal function in DOCA-salt hypertensive rats. We also determined whether ROS-induced renal injury was dependent on blood pressure. DOCA-salt hypertensive rats exhibited a marked increase in blood pressure, renal ROS production, glomerular and tubular lesions, and microalbuminuria compared to sham rats. Treatment of DOCA-salt hypertensive rats with apocynin for 28 days resulted in attenuation of systolic blood pressure and improvement of renal morphology. Renal superoxide level in DOCA-salt rats was 215% of sham-operated rats and it was significantly decreased to 140% with apocynin treatment. Urinary protein level was decreased from 27 ± 3 mg/day in DOCA-salt hypertensive rats to 9 ± 2 mg/day. 28 days of Vitamin E treatment also reduced renal injury in regard to urinary protein level and renal morphology but had no effect on blood pressure in DOCA-salt rats. Increased urinary 8-isoprostane, a marker for oxidative stress, in DOCA-salt hypertensive rats (55 ± 8 ng/day) was diminished by vitamin E treatment (24 ± 6 ng/day). These data suggest that renal injury characteristic of mineralocorticoid hypertension is associated with oxidative stress and is partly independent of blood pressure.

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