Wyniki wyszukiwania

1

The hydrophobic effect: thermodynamics of micelle formation

100%

Fisicaro E.

Biophysics of Membrane Transport

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1992

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tom 11

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nr 1

2

Hydration of C-H groups in natural dithymidine nucleotide and its methylphosphonate analogues

84%

Kulinska K., Kulinski T., Stawinski J.

Acta Biochimica Polonica

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1998

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tom 45

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nr 4

In this paper we report our preliminary studies on the hydration pattern of selected C-H groups in natural thymidyl(3'-5)thymidine and its RP and SP-methylphosphonate analogues using Molecular Dynamic simulations in aqueous solutions. The methyl groups attached to the phosphorus center (P-Me) in methylphosphonate analogues are hydrated by water molecules as efficiently as the hydrophilic P=O group in the natural dithymidine nucleotide and better than the neutral P=O functions in these compounds, although the nature of the hydration is different. The C5-Me centers of the 3'-yl units seem to be better hydrated in the methylphosphonate analogues than in the natural dithymidine phosphate and than other centers of the thymine basesin methylphosphonate analogues. Due to chirality of the phosphorus center, the C5-Me group of the 5'-yl unit in the SP diastereomer coordinates more water than that in the RP diastereomer. The C6-H group in the 5'-yl unit of the SP diastereomer exhibits a specific interaction with water.

3

Elaboration and specific properties of fluorinated liposomes and related supramolecular systems

67%

Krafft M. P., Riess J. G.

Cellular and Molecular Biology Letters

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1996

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tom 01

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nr 4

A range of well defined, pure, highly surface-active but non-hemolyzing fluorinated amphiphiles has recently been synthesized. Fluorocarbon chains strongly enhance the hydrophobic effect that induces the organization of amphiphiles into bilayer membranes, and supplement it with a lipophobic effect as well. This leads to an augmented tendency for fluorinated amphiphiles to selfassemble into vesicles (liposomes), tubules and other supramolecular aggregates when dispersed in water and other solvents. Fluorinated bilayers and vesicles are generally more stable and less permeant than those made from hydrocarbon analogs. The presence of a fluorinated film inside the liposomal membrane also has significant repercussions on the behavior of the liposomes in a biological milieu and on their in vivo recognition.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Biophysics of Membrane Transport

1 Cellular and Molecular Biology Letters

1 Fisicaro E.

1 Krafft M. P.

1 Kulinska K.

1 Kulinski T.

1 Riess J. G.

1 Stawinski J.

1 1998

1 1996

1 1992

The hydrophobic effect: thermodynamics of micelle formation

Hydration of C-H groups in natural dithymidine nucleotide and its methylphosphonate analogues

Elaboration and specific properties of fluorinated liposomes and related supramolecular systems