Wyniki wyszukiwania

1

Clinical use and therapeutic potential of IVIG/SCIG, plasma-derived IgA or IgM, and other alternative immunoglobulin preparations

100%

Spath P. J., Schneider C., von Gunten S.

Archivum Immunologiae et Therapiae Experimentalis

|

2017

|

tom 65

|

nr 3

2

Host nuclear factor erythroid 2-related factor 2 defense system determines the outcome of dextran sulfate sodium - induced colitis in mice

80%

Lee J. S., An J. M., Kang E. A., Han Y. M., Kim Y. S., Lee H. J., Kim K.-J., Surh Y. J., Hahm K.-B.

Journal of Physiology and Pharmacology

|

2018

|

tom 69

|

nr 5

3

The evolutionary role of the IL-33/ST2 system in host immune defence

80%

Sattler S., Smits H. H., Xu D., Huang F.-P.

Archivum Immunologiae et Therapiae Experimentalis

|

2013

|

tom 61

|

nr 2

4

Use of HIV as a gene transfer vector

61%

Pluta K., Kacprzak M. M.

Acta Biochimica Polonica

|

2009

|

tom 56

|

nr 4

531-595

Despite the extensive research efforts over the past 25 years that have focused on HIV, there is still no cure for AIDS. However, tremendous progress in the understanding of the structure and biology of the HIV virus led to the development of safe and potent HIV-based transgene delivery vectors. These genetic vehicles are referred to as lentiviral vectors. They appear to be better suited for particular applications, such as transgene delivery into stem cells, compared to other viral- and non-viral vectors. This is because Lentivirus-based vectors can efficiently infect nondividing and slowly dividing cells. In the present review article, the current state of understanding of HIV-1 is discussed and the main characteristics that had an impact on vector design are outlined. A historical view on the vector concept is presented to facilitate discussion of recent results in vector engineering in a broader context. Subsequently, a state of the art overview concerning vector construction and vector production is given. This review also touches upon the subject of lentiviral vector safety and related topics that can be helpful in addressing this issue are discussed. Finally, examples of Lentivirus-based gene delivery systems and their applications are presented, with emphasis on animal transgenesis and human gene therapy.

Ograniczanie wyników

2 Archivum Immunologiae et Therapiae Experimentalis

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 An J. M.

1 Hahm K.-B.

1 Han Y. M.

1 Huang F.-P.

1 Kacprzak M. M.

1 Kang E. A.

1 Kim K.-J.

1 Kim Y. S.

1 Lee H. J.

1 Lee J. S.

1 Pluta K.

1 Sattler S.

1 Schneider C.

1 Smits H. H.

1 Spath P. J.

1 Surh Y. J.

1 Xu D.

1 von Gunten S.

1 2018

1 2017

1 2013

1 2009

Clinical use and therapeutic potential of IVIG/SCIG, plasma-derived IgA or IgM, and other alternative immunoglobulin preparations

Host nuclear factor erythroid 2-related factor 2 defense system determines the outcome of dextran sulfate sodium - induced colitis in mice

The evolutionary role of the IL-33/ST2 system in host immune defence

Use of HIV as a gene transfer vector