Wyniki wyszukiwania

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Short-time dynamics of changes in biochemical parameters and dose - effect relations in acute intoxication of mice with carbon tetrachloride

100%

Skrzypinska-Gawrysiak M., Piotrowski J. K., Jasiukiewicz J.

Acta Poloniae Toxicologica

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1998

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tom 06

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nr 2

209-219

2

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Hepatoksyczność wybranych polichlorowanych węglowodorów aromatycznych

100%

Syrowatka T., Bankowska J.

Roczniki Państwowego Zakładu Higieny

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1982

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tom 33

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nr 4

3

Zagadkowy topinambur

84%

Labisz M.

Zachodniopomorski Magazyn Rolniczy

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2005-2006

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nr 05

4

Cytotoksycznosc salinomycyny i lazolocydu wobec hepatocytow modelowej linii komorkowej szczura

84%

Radko L., Cybulski W., Rzeski W.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 07

839-842

The aims of the study were determining the median cytotoxicity indicate (IC50), nature of cell death (apoptosis/ necrosis), assessment and morphology of changes observed in FAO cell line culture of hepatocytes subjected to ionophore antibiotics, salinomycin and lasalocid, incubations. INVTTOX recommended MTT, NRU and KB cytotoxicity tests were used to research mitochondrial, protein synthesis and cell proliferation. In addition cell staining in order to reveal membrane destruction that established cell death character May-Grunwald & Giemsa staining were also conducted. Cytotoxicity indices (IC50) estimated by the 24 hour MTT test were at a level 2.41 ± 0.29 mM and 7.93 ± 0.01 mM; however, after a 48 hour incubation the values lowered to 0.112739 ± 0.01 mM and 0.59 ± 0.01 mM for salinomycin and lasalocid, respectively. In contrast to the MTT data, that of NRU and KB tests were higher, indicating mitochondria as the main subcellular target for the antibiotic action. The determined IC50 values were positively related to DL50 (the data from references). Hepatocytes death were established to be of an apoptosis nature. Cell morphology was changed from IC50 depending on manner; the lower value of the indicate corresponded to more pronounced cytopathologic findings. Summarizing, monolayer cell cultures of rat hepatocytes proved to serve as a useful model for cytotoxicity studies enabling to indicate subcellular targets for ionophore antibiotics

5

Effect of ethylbenzene on metabolism and hepatotoxicity of trichloroethylene in rats

84%

Starek A.

Acta Poloniae Toxicologica

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1997

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tom 05

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nr 1

47-54

6

Mechanizmy toksyczności ołowiu

67%

Giel-Pietraszuk M., Hybza K., Chelchowska M., Barciszewski J.

Postępy Biologii Komórki

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2012

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tom 39

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nr 2

7

Patogenne działanie ochratoksyny A

67%

Rouibah K., Houszka M., Dzimira S.

Medycyna Weterynaryjna

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2013

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tom 69

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nr 02

Some fungi in specific environmental conditions may produce mycotoxins, especially ochratoxin A. It is produced mainly by Aspergillus ochraceus, A. carbonarium and Penicillium verrucosum, and commonly occurs in foodstuff and feed products. Ochratoxin A is metabolized in the organism in the liver and excreted mainly by the urinary way as well as with bile and feces. After absorption by the organism, ochratoxin binds blood serum proteins, which retards its direct toxic action but elongates its half time. Ochratoxin A demonstrates a multifactorial pathological influence, especially nephrotoxic, hepatotoxic, immunotoxic and carcinogenic. By damaging the mechanism responsible for the organic anion transport in epithelial cells brush border of the proximal convoluted tubules it causes kidney dysfunction. The disturbance of protein synthesis negatively influences mitotic divisions and differentiation of rapidly dividing cells in the immunologic system and mucus membrane of the digestive tract. Ochratoxin causes periodical inhibition of osteoblast proliferation, collagen fibers synthesis and bone mineralization. In humans ochratoxin is recognized as the main etiologic factor of Balkan Endemic Nephropathy, while in pigs it causes a disease named mycotoxicose nephropathy.

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Opieka nad pacjentem podczas chemioterapii - praktyczne wskazówki. Cz. II. Rzadziej występujące działania niepożądane

67%

Purzycka K.

Magazyn Weterynaryjny

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2018

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tom 27

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nr 05

9

Immunotoksyny - charakterystyka i zastosowanie

51%

Kaminski M., Stachowiak R., Bielecki J.

Postępy Mikrobiologii

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2010

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tom 49

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nr 4

10

Mechanizmy hepatotoksycznosci alfa-amanityny oraz porownanie skutecznosci odtrutek stosowanych w terapii zatruc muchomorem sromotnikowym - przeglad badan na hodowlach komorkowych

51%

Magdalan J.