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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Synergistic antiplatelet action of nitric oxide [NO] with PGD2 and its metabolite PGJ2 - relevance for cerebral circulation?

100%
Rodrigues M., Fitscha P., Sinzinger H.
Journal of Physiology and Pharmacology
|
1994
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tom 45
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nr 4
2
Content available remote

Elevated plasma levels of tissue factor as a valuable diagnostic biomarker with relevant efficacy for prediction of breast cancer morbidity

86%
Zarychta E., Rhone P., Bielawski K., Rosc D., Szot K., Zdunska M., Ruszkowska-Ciastek B.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 6
3

Molecular structure and biological function of von Willebrand factor

86%
Bykowska E.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
4

A pilot study of tissue factor-tissue factor pathway inhibitor axis and other selected coagulation parameters in broiler chickens administered in ovo with selected prebiotics

86%
Buzala M., Ponczek M. B., Slomka A., Roslewska A., Janicki B., Zekanowska E., Bednarczyk M.
Folia Biologica
|
2016
|
tom 64
|
nr 4
5
Content available remote

Antithrombotic effect of L-arginine in hypertensive rats

86%
Cylwik D., Mogielnicki A., Kramkowski K., Stokowski J., Buczko W.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 3
The aim of the study was to evaluate the effect of L-arginine (L-Arg) on haemostasis in stasis model of venous thrombosis in renal hypertensive rats. The effect of the single dose (i.v.300 mg/kg bolus+300 mg/kg/h) and of the 10-day application (p.o. 1 g/kg, once daily) of L-Arg was determined. L-Arg reduced the blood pressure both in the acute and long-term application. The single dose of L-Arg decreased the occurrence rate of the thrombus whereas long-term administration reduced significantly the thrombus weight. There were no differences in prothrombin time and activated partial thromboplastin time while the fibrinogen concentration decreased both in the acute and the long-term experiment. L-Arg shortened euglobulin clot lysis time and bleeding time in the long-term application. The chronic L-Arg treatment also inhibited significantly collagen-induced platelet aggregation. The overall haemostasis and coagulation potentials were inhibited and the fibrinolysis potential was higher in the group receiving this amino-acid. The results show that L-Arg, in a complex way, evokes the antithrombotic effect in the model of venous thrombosis in hypertensive rats.
6

Platelet influence on T- and B-cell responses

72%
Sowa J. M., Crist S. A., Ratliff T. L., Elzey B. D.
Archivum Immunologiae et Therapiae Experimentalis
|
2009
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tom 57
|
nr 4
235-241
7
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Experimental studies on the anticoagulant and antithrombotic effects of sodium and calcium pentosan polysulphate

72%
Giedrojc J., Radziwon P., Klimiuk M., Bielawiec M., Breddin H. K., Kloczko J.
Journal of Physiology and Pharmacology
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1999
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tom 50
|
nr 1
8

Adenosine diphosphate receptors on blood platelets - potential new targets for antiplatelet therapy

72%
Rozalski M., Nocun M., Watala C.
Acta Biochimica Polonica
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2005
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tom 52
|
nr 2
Platelets play a key role not only in physiological haemostasis, but also under pathological conditions such as thrombosis. Platelet activation may be initiated by a variety of agonists including thrombin, collagen, thromboxane or adenosine diphosphate (ADP). Although ADP is regarded as a weak agonist of blood platelets, it remains an important mediator of platelet activation evoked by other agonists, which induce massive ADP release from dense granules, where it occurs in molar concentrations. Thus, ADP action underlies a positive feedback that facilitates further platelet aggregation and leads to platelet plug formation. Additionally, ADP acts synergistically to other, even weak, agonists such as serotonin, adrenaline or chemokines. Blood platelets express two types of P2Y ADP receptors: P2Y1 and P2Y12. ADP-dependent platelet aggregation is initiated by the P2Y1 receptor, whereas P2Y12 receptor augments the activating signal and promotes platelet release reaction. Stimulation of P2Y12 is also essential for ADP-mediated complete activation of GPIIb-IIIa and GPIa-IIa, and further stabilization of platelet aggregates. The crucial role in blood platelet biology makes P2Y12 an ideal candidate for pharmacological approaches for anti-platelet therapy.
9

Assessment of the influence of the inflammatory process on the activation of blood platelets and morphological parameters in patients with ulcerative colitis (colitis ulcerosa)

58%
Polinska B., Matowicka-Karna J., Kemona H.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 1
10
Content available remote

Gender differences in hemostatic and inflammatory factors in patients with acute coronary syndromes: a pilot study

58%
Siennicka A., Jastrzebska M., Smialkowska K., Oledzki S., Chelstowski K., Klysz M., Clark J., Kornacewicz-Jach Z.
Journal of Physiology and Pharmacology
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2018
|
tom 69
|
nr 1
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The effect of cis-diamminedichloroplatinum, selenite and a conjugate of cisplatin with selenite [[NH3]2Pt[SeO3]] on oxidative stress in blood platelets measured by chemiluminescence method

58%
Olas B., Zbikowska H. M., Wachowicz B., Buczynski A., Krajewski T.
Journal of Physiology and Pharmacology
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1999
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tom 50
|
nr 2
12

In comparison to progenitor platelets, microparticles are deficient in GpIb, GpIb-derived carbohydrates, glycerophospholipids, glycosphingolipids, and ceramides

58%
Zdebska E., Wozniak J., Dzieciatkowska A., Koscielak J.
Acta Biochimica Polonica
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1998
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tom 45
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nr 2
Activated blood platelets shed microparticles with procoagulant activity that probably participate in normal hemostasis. We have isolated spontaneously formed microparticles from human blood and analysed them for ultrastructure, antigenic profile, and biochemical composition. In transmission electron microscopy microparticles appeared as regular vesicles with a mean diameter of 300 nm (50-600 nm). In flow cytometry almost all microparticles reacted with fluorescein isothiocyanate (FITC) labeled antibody to platelet glycoprotein complex IIb-IIIa (GpIIb-IIIa) and with FITC-annexin V but only 40-50% of microparticles reacted with FITC-antibody to platelet glycoprotein Ib (GpIb). The latter result was confirmed by double labeling of microparticles with FITC-antibody to GpIIb-IIIa and phycoerythrin (PE) labeled antibody to GpIb. Large microparticles reacted better with anti-GpIb than the small ones. A decreased level of GpIb was also demonstrated by SDS/polyacrylamide gel electrophoresis of microparticles. Compositional studies indicated, that in terms of cholesterol and protein contents, microparticles resembled platelets rather than platelet membranes as previously thought. They are, however, deficient in certain components. Thus, in comparison to platelets, microparticles had reduced contents of sialic acid (by 56.4%), galactosamine (by 48.2%), glucosamine (by 22.4%), galactose by (11.8%) and fucose (by 21.6%). Mannose content was increased by 11.8%. Total phospholipids in microplatelets were lower by 17.8%. Glycerophospholipids only were affected with phosphatidylserine being decreased as much as by 43.2%. Neutral glycosphingolipids, gangliosides and ceramides in microparticles were reduced by half. We conclude that the biochemical composition of microparticles probably reflects previous activation of progenitor platelets
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion

58%
Zbikowska H. M., Olas B.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 3
14
Content available remote

Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats

58%
Wojewodzka-Zelazniakowicz M., Chabielska E., Mogielnicki A., Kramkowski K., Karp A., Opadczuk A., Domaniewski T., Malinowska-Zaprzalka M., Buczko W.
Journal of Physiology and Pharmacology
|
2006
|
tom 57
|
nr 2
This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and Tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect of ACE-Is was equal in all groups. QUIN mantained the final carotid blood flow at the highest value in comparison to PER and plasma ACE-Is. The arterial thrombus weight was reduced in PER and QUIN groups while venous thrombus weight was also reduced after CAP. Tissue andplasma ACE-Is caused the inhibition of platelet adhesion and aggregation. A reduction of fibrin generation, prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and shortening of euglobulin clot lysis time (ECLT) were observed after PER and QUIN treatment. In conclusion, given in equipotent hypotensive doses, Tissue ACE-Is exerted more pronounced antithrombotic effect than plasma ACE-Is in experimental thrombosis. The differences between Tissue and plasma ACE-Is in terms of their more pronounced inhibition of experimental thrombosis may be related to the intensified activation of fibrinolysis and inhibition of coagulation.
15

Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.IV. Wplyw na funkcje hemostatyczne plytek krwi

51%
Gacko M., Jurkowski J., Tomasiak M., Worowska A., Worowski K.
Bromatologia i Chemia Toksykologiczna
|
1995
|
tom 28
|
nr 3
241-248
W 18 spośród 26 badanych napojów alkoholowych występują związki chemiczne hamujące agregację płytek i refrakcję skrzepu krwi oraz upośledzające lub zwiększające zużycie protrombiny.
16

Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.II. Wplyw na uklad krzepniecia krwi

44%
Jurkowski J., Gacko M., Worowski K.
Bromatologia i Chemia Toksykologiczna
|
1995
|
tom 28
|
nr 1
45-50
Określono wpływ 26 napojów alkoholowych, ich destylatów i pozostałości podestylacyjnej na aktywację protrombiny w systemie zewnątrzpochodnym i wewnątrzpochodnym oraz na aktywność trombiny.
17

Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.III. Wplyw na uklad fibrynolityczny osocza

44%
Jurkowski J., Gacko M., Worowski K.
Bromatologia i Chemia Toksykologiczna
|
1995
|
tom 28
|
nr 2
185-192
Określono wpływ 26 napojów alkoholowych, ich destylatów i pozostałości podestylacyjnych na aktywność fibrynolityczną i kazeinolityczną euglobulin osoczowych i plazminy.
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