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Chronic mountain sickness: the reaction of physical disorders to chronic hypoxia

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Chronic mountain sickness (CMS) is a condition in which hematocrit is increased above the normal level in residents at high altitude. In this article we take issue with the ‘Consensus Statement On Chronic And Subacute High Altitude Diseases” of 2005 on two essential points: using a questionnaire to evaluate the symptoms of CMS to use the term “loss of adaptation” as opposed to “adaptation to disease in the hypoxic environment”. We opine that CMS is rather an adaptive reaction to an underlying malfunction of some organs and no specific symptoms could be quantified. To substantiate our line of reasoning we reviewed 240 CMS cases seen at the High Altitude Pathology Institute in La Paz. Patients who had a high hematocrit (>58%) underwent pulmonary function studies in search for the cause of hypoxia: hypoventilation, diffusion alteration, shunts, and uneven ventilation-perfusion. The tests included arterial blood gas tests, chest x-rays, spirometry, hyperoxic tests, flow-volume curves, ventilation studies at rest and during exercise, ECG, exercise testing and doppler color echocardiography to assess heart structure and function. When correlated with clinical history these results revealed that CMS is practically always secondary to some type of anomaly in cardio-respiratory or renal function. Therefore, a questionnaire that tries to catalog symptoms common to many types of diseases that lead to hypoxia is flawed because it leads to incomplete diagnosis and inappropriate treatment. CMS, once again, was shown to be an adaptation of the blood transport system to a deficient organs’ function due to diverse disease processes; the adaptation aimed at sustaining normoxia at the cellular level in the hypoxic environment at high altitude.
Background. Fish are the principal source of n-3 and n-6 fatty acids for humans. Traditionally, these fatty acids have been supplied in the form of captured marine and freshwater fishes. Recently, freshwater cultured species have been increasing their share in the fish volume on the market. Therefore it is crucial for fish farmers to rear fish under proper condition and with proper feeding in order to receive good quality fish flesh at harvest. The presently reported study was aimed at determining the effect of diet with the increased level of lipids or carbohydrates on selected blood indices, reduced glutathione content, lipid peroxidation products concentration in the liver, and body weight gains in carp fingerlings reared in post-cooling waters. Materials and Methods. The experiment was carried out in spring (2004) on 300 carp divided into two feeding groups. Group I was fed high-fat feed, whereas group II high-carbohydrate feed. After 7 weeks, fish blood and livers were collected for further analyses. Results. Significantly higher body weight gains were found in the fish fed high-fat feed as well as significant increase of haemoglobin (Hb) concentration in the blood of both feeding groups, which was accompanied by the increase of haematocrit (Ht) index. Furthermore, an increase in the concentration of lipid peroxidation products was observed as well as significantly lower content of reduced glutathione (GSH) in the livers of fish examined. Conclusion. The observed MDA values and reduced glutathione (GSH) concentration in the fish liver may indicate enhanced peroxidation processes in the organisms of the fish from both experimental groups, caused by their intensive feeding with extruded feeds. The peroxidation processes were more intensive in fish fed high-fat feeds.
Blood parameter changes have been investigated after short-term road transport stress in 18 crossbred dairy cows in northwest of Iran. Cows were transported in 4 groups of four cows and one group of two cows in five different days. Each group was transported by truck up to a 40 km round trip for an hour. Blood was taken in 5 ml amounts from the jugular vein from each cow before transport and then repeated bleeding at 1.5 hours intervals up to 7.5 hours after transportation. Blood samples were assessed for cortisol, (ELISA), glucose, calcium (Ca), phosphorus (IP), magnesium (Mg) (spectrophotometer method), sodium (Na), potassium (K) (flame Photometer), total protein (TPP), fibrinogen (Refractometer method), leucocytes and differential count. Blood cortisol, glucose and leucocytes count increased up to 340%, 48.6% and 23% within 1.5, 7.5 and 6 hours after transport, respectively. Haematocrit decreased up to 17% after 7.5 hours transport. The mean differences (Wilk.s Lambda) for these parameters before and after transport were significant (P < 0.05). The mean differences for Ca, IP, Mg and eosinophil count were also significant (P < 0.05). The highest changes were observed for glucose, hematocrit after 7.5 hours, Ca and the leucocytes count after 6 hours, cortisol after 1.5 hours and the lymphocyte count after 3 hours of transportation. There were significant (P < 0.05) relationships between cortisol&Mg (r = .0.54), cortisol&TPP (r = .0.55), cortisol&fibrinogen (r = .0.52), cortisol&neutrophil (r = .0.52) cortisol & lymphocyte count (r = 0.79) 3 hours after transport. It is concluded that short-term road transport stress increased blood cortisol, that changes in the blood parameters are mainly due to glucose, hematocrit, and leucocyte count and blood electrolytes. Although these changes were within the reference range for cattle, since these parameters are known as health parameters in a ruminant.s life they should be considered during the transportation.
The objectives of this study were to evaluate the serum protein electrophoresis pattern in dogs infected with B. canis, and correlation between haematocrit and albumin/globulin ratio. The infection with B. canis was confirmed by PCR and sequencing of PCR products. Total serum protein concentrations were determined by a clinical chemistry analyser. Albumin, α₁-, α₂-, β₁-, β₂-, and γ-globulin concentrations were assayed by densitometric analysis after electrophoretic separation of serum proteins on agarose gel. The most common disorders in affected dogs were decreased α-globulin fractions, increased ß-globulin concentration, increased albumin/globulin (A/G) ratio, and hypoglobulinaemia. A decrease in ar and α₂-globulin concentration was detected accordingly in 54.8% and 32.3% of dogs. An increase in β₁- and β₂-globulin concentration, and increased A/G ratio was detected accordingly in 38.7%, 51.6%, and 38.7% of dogs. Hypoglobulinaemia was detected in 32.3% dogs. Changes detected in this study probably result from haemolysis, hypertransferrinaemia, increased C3a protein concentration (complement), and dehydration.
The purpose of the present research is compare the effects of coagulation factors in nonathletes gilrs after exhaustive anaerobic activity .Present study was semi-emprical that was done on 12 non-athlete female students in range of 18-24 years. Exercise protocol was RAST test, that in which each person passed amain 35 meters of distance for 6 times and rest 10 seconds between each stage.Blood sampling was performed in two stages (before and after).Datas were analyzed with Kolmogorov Smirnov test, Levine's test and two-way ANOVA level (p < 0/05 ). The results showed that anaerobic exercise had a significant influence on partial time Thromboplastin (PTT), and fibrinogen in non-athletic subjects.But there was not significative difference on Prothrombin time (PT), platelet and hematocrit.Findings suggested that a meeting of anaerobic exercise on blood coagulation factor, effectiveness and changes in some of the invoices for training program Drafradghyrfal is important.
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