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Daily pattern of breathing in healthy young men

100%

Adamczyk W., Tafil-Klawe M., Siekierka M., Zlomanczuk P., Weber P., Klawe J. J.

Journal of Physiology and Pharmacology. Supplement

2008

tom 59

nr 6

115-122

Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men

80%

Krzeminski K., Mikulski T., Nazar K.

Journal of Physiology and Pharmacology

2006

tom 57

nr 4

The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and whether it is related to the hormonal, metabolic and cardiovascular changes. Eighteen healthy subjects (age 25±1 yrs) were submitted to cycle exercise for 90 min at 70% of maximal oxygen uptake. Heart rate (HR) and blood pressure (BP) were measured continously. Before, at 30th min, and at the end of exercise venous blood samples were taken for [ADM], noradrenaline [NA], adrenaline [A], atrial natriuretic peptide [ANP], plasma renin activity PRA, interleukin-6 [IL-6] and lactate [LA] determination. Significant increases in plasma ADM and IL-6 were found at 90th min whereas other hormones were elevated already at 30th min of exercise. Positive correlations were ascertained between [ADM] and [NA] (r=0.47), [ANP] (r=0.35) or [IL-6] (r=0.35) and between exercise-induced increases in [ADM] and [NA] (r=0.38). PRA correlated positively with [NA] and [ANP]. Negative correlation was found between plasma [ADM] and diastolic BP. The present data suggest that increase in sympathetic nervous activity and cytokine induction during prolonged exercise may be involved in plasma ADM release and that increase in ADM and ANP secretion may be a compensatory mechanism against further elevation of blood pressure.

Effect of 6-week endurance training on hemodynamic and neurohormonal responses to lower body negative pressure (LBNP) in healthy young men

80%

Nazar K., Gasiorowska A., Mikulski T., Cybulski G., Niewiadomski W., Smorawinski J., Krzeminski K., Ziemba A. W., Dorsz A., Kaciuba-Uscilko H.

Journal of Physiology and Pharmacology

2006

tom 57

nr 2

Endurance training is considered as a factor impairing orthostatic tolerance although an improvement and lack of effect have been also reported. The mechanisms of the changes and their relation to initial tolerance of orthostasis are not clear. In the present study, effect of moderate running training on hemodynamic and neurohormonal changes during LBNP, a laboratory test simulating orthostasis, was investigated in subjects with high (HT) and low (LT) tolerance of LBNP. Twenty four male, healthy subjects were submitted to graded LBNP (-15, -30 and -50 mmHg) before and after training. During each test heart rate (HR), stroke volume (SV) and blood pressure, plasma catecholamines, ACTH, adrenomedullin, atrial natriuretic peptide, and renin activity were determined. Basing on initial test, 13 subjects who withstood LBNP at -50 mmHg for 10 min were allocated into HT group and 11 subjects who earlier showed presyncopal symptoms to LT group. Training improved LBNP tolerance in six LT subjects. This was associated with attenuated rate of HR increase and SV decline (before training, at -30 mmHg DHR was 21 ± 4 beats/min and SV – -36± 8 ml while after training the respective values were 8 ± 4 beats/min and -11± 6 ml). No differences in hemodynamic response were found in HT subjects and those from LT group whose LBNP tolerance was unchanged. In neither group training affected neurohormonal changes except inhibition of plasma ACTH rise in subjects with improvement of LBNP tolerance. It is concluded that some subjects with low orthostatic tolerance may benefit from moderate training due to improvement of cardiac function regulation.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

2 Krzeminski K.

2 Mikulski T.

2 Nazar K.

1 Adamczyk W.

1 Cybulski G.

1 Dorsz A.

1 Gasiorowska A.

1 Kaciuba-Uscilko H.

1 Klawe J. J.

1 Niewiadomski W.

1 Siekierka M.

1 Smorawinski J.

1 Tafil-Klawe M.

1 Weber P.

1 Ziemba A. W.

1 Zlomanczuk P.

1 2008

2 2006

Wyniki wyszukiwania

Daily pattern of breathing in healthy young men

Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men

Effect of 6-week endurance training on hemodynamic and neurohormonal responses to lower body negative pressure (LBNP) in healthy young men