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Since the mid-eighties, the Polish society has witnessed a steady increase in the 65+ population. This demographic trend calls for a change in the organisation of health services and healthcare for this segment of the society. Old age is a difficult period in human life, especially if one has not been prepared for it. Individuals experience a number of health restrictions, while the quality of life at that stage of life depends mostly on the accuracy of identifying health needs, their types and the quality of the available solutions. The following paper aims to present literature on the most common health problems amongst the elderly in Poland. Numerous scientific centres in Poland (and abroad) which work with seniors have confirmed that the health situation of this age group is highly unsatisfactory. Seniors often face problems which affect their functioning, independence and self-care. Impairment may be caused by geriatric disorders, which include cardiovascular diseases (the most common cause of death in Poland among persons aged 65+), cancer, diabetes, balance disorders, impaired mobility, falling down, dementia, depression, insomnia, incontinence, soiling, impaired vision and hearing, lower limb muscle cramps at night, and bedsores. The rapid ageing of the society poses numerous challenges for healthcare organisers, educators and doctors with regard to educating, preventing and treating seniors in Poland.
Depression is one of the most common affective disorders. According to the World Health Organization (WHO), it is currently the fourth major global health problem (Kessler et al. 2003). The growing number of people suffering from depression has motivated the scientists to search for new antidepressant drugs. Since numerous studies revealed that NMDA receptor may be involved in the mechanism of action of the antidepressant agents, modulation of the NMDA receptor function by different ligands has been taken into consideration. There are some promising results demonstrating the antidepressant activity of the antagonists binding to the polyamine site of the NMDA receptor complex. Ifenprodil belongs to a family of the selective, atypical non-competitive antagonists of the NMDA receptors. It acts via inhibition of the polyamine binding site of the NR2B subunit (Williams 1993). An antidepressantlike effect of ifenprodil was observed in several behavioral studies, for example in the forced swimming test (Carter et al. 1990, Williams 1993, Layer et al. 1995, Scolnik 1999, Paoletti and Neyton 2007). It was shown that its antidepressant-like activity is increased by other antidepressant drugs (imipramine and fluoxetine). The aim of our work was to evaluate the antidepressant activity of the joint administration of ifenprodil and NMDA ligands in the mouse forced swimming test (FST). The experiments were carried out on male Albino Swiss mice. In order to avoid the risk of obtaining the false positive/negative effects in the FST test caused by a possible influence of the tested substances on the locomotor activity, the spontaneous locomotor activity was measured. The obtained results demonstrated that ifenprodil at the dose of 10 mg/ kg enhances the antidepressant-like effect of the following NMDA receptor ligands: a competitive NMDA receptor antagonist – CGP 37849 (0.312 mg/kg), an antagonist at glycine site – L-701,324 (1 mg/kg) and a non-competitive antagonist at phencyclidyne – MK801 (0.05 mg/kg). However, it did not potentiate the antidepressant activity of the inorganic modulators of the NMDA receptor complex, such as Zn2+ (2.5 mg/kg) and Mg2+ (10 mg/kg). Treatment with the tested agents did not influence the locomotor activity. In conclusion, our findings indicated that antidepressant-like activity of ifenprodil is connected with serotoninergic and glutamatergic system.
Intestinal parasitic diseases in Gaza Strip are a significant health problem. The main aim of this study is to determine the prevalence of parasitic infection among patients in the five governorates of the Gaza Strip. A crosssectional parasitological survey was conducted on 600 patients. Stool specimens were examined microscopically for the presence of parasite eggs or larvae/cysts per wet amount by the saline iodine and formol-ether concentration method. Of 600 subjects examined, 245 (40.8%) were infected with one or more intestinal parasites. Entamoeba histolytica/dispar and Giardia lamblia were the most prevalent parasites amongst the population (28.8%), (9.5%). Female patients demonstrated a higher prevalence of intestinal parasitic infections (42.7%) than males (39.0%). However, this difference was not significant (p>0.05). According to occupation, the rate of infection was highest among farmers (56.0%), followed by employers (44.2%) with laborers showing the lowest rate (30.17%). These differences in occupational prevalence were found to be statistically significant (p<0.05). The present study demonstrates that intestinal protozoan infections are still a public health problem in the Gaza strip, with Entamoeba and Giardia infections being most common. Therefore, it is necessary to develop effective prevention and control strategies, including health education and environmental sanitation improvement.
One of the primary aims in tuberculosis (TB) management is to detect new cases as early as possible, and instigate the most appropriate therapy, for which it is important to know the characteristics of TB drug resistance in society. The aim of our study was to determine the resistance status of tuberculosis in the Samsun region of Turkey. To achieve that, the medical records of 1,029 pulmonary tuberculosis patients admitted to Samsun Chest Diseases and Chest Surgery Hospital between 2004 and 2006 were analyzed for drug resistance characteristics. In order to define the problem, isolates were tested on Lowenstein-Jensen medium. For drug susceptibility testing, isoni-azid (1), streptomycin (S), ethambutol (E), rifampicin (R) and the radiometric Bactec 460 TB system were used. Eighty-six percent (86%) of the cases (623/721) were new patients, and 13.5% (98/721) were previously treated cases. One hundred and thirty-four (134) of the 721 patients (18.6%) had resistance to one or more drugs. Resistance to any drug was determined in 16.9% (105/623) cases of new patients. I resistance was 13.2%, any R resistance was 2.9%, and multi-drug resistance (MDR) was 1.9%. In previously treated cases, resistance to any drug was 29.6%, any I resistance was 26.5%, any R resistance was 15.3%, and MDR was 13.3%. It was concluded that resistance to anti-tuberculosis drugs is an important problem in Samsun.
The aim of the study was an attempt to evaluate the state of health of adolescents aged 15 years, living in Podlasie region near the border of Poland and Bielorus. Data from the Schoolchild Development and Health Investigation Charts covering 197 rural and 208 urban adolescents were analyzed. The significance of differences between the two populations were tested by Chi-square test at the level of p>0.05. The study showed that nearly 60% of rural and 70% of urban schoolchildren have health problems. The most common of these problems are associated with the body posture. The data on self-reported health indicated that the most often observed complaints in both populations (rural and urban) of adolescents were: headaches, difficulties with falling asleep and lack of appetite. In spite of the high incidence of health problems, the number of schoolchildren being attended by medical specialists in outpatient departments is relatively small, to the disadvantage of the rural population. The laryngology and ophthalmology departments were visited most frequently. The analysis of the results of the studies confirmed that the state of health of the children examined is unsatisfactory. An effective prevention of these negative phenomena requires the creation of efficient systemic mechanisms on the one hand, and on the other, a constant monitoring of objective and self-reported health.
Artykuł, w oparciu o wyniki wieloletnich badań i opublikowane prace, omawia najczęstsze zagrożenia zdrowotne związane z aktualnym żywieniem ludności w Wietnamie. Po zakończeniu w 1975 roku długotrwałej i wyniszczającej wojny w Wietnamie, jedną z najpilniejszych spraw była poprawa stanu odżywienia ludności. Z ostatnio przeprowadzonych badań nad sposobem żywienia i stanem odżywienia ludności wynikało, że przeciętna wartość energetyczna dziennej racji pokarmowej na wsi wynosiła 1925 kcal. Jest to wartość niższa o około 15% od zalecanej normy zapotrzebowania. Udział energii z tłuszczów wynosił zaledwie 6%ogólnej ilości energii a udział energii z białka był równy około 11%, jednak tylko 18% tego białka pochodziło z produktów zwierzęcych. Najważniejszym rodzajem niedoboru żywieniowego dzieci okazał się niedobór energetyczno-białkowy, który objawiał się najczęścej w postaci zahamowania ich rozwoju fizycznego. U osób dorosłych odsetek ludzi z niską względną masą ciała (BMI) świadczącą m.in. o niedoborze energii zwiększał się wraz z wiekiem. Z innych najczęściej występujących niedoborów w populacji dzieci wietnamskich wymienić należy niedobór witaminy A i kseroftalmię. Zagrożenie niedoborem witaminy A i kseroftalmią wynikało z faktu, że wietnamska dzienna racja pokarmowa jest uboga w produkty dostarczające witaminy A oraz w tłuszcze, a warzywa bogate w karotenoidy są niechętnie podawane małym dzieciom. Kolejnym częstym objawem złego stanu odżywenia ludności jest niedokrwistość występująca u kobiet w wieku rozrodczym i u dzieci. Ponadto w regionach górzystych spotyka się często występowanie wola endemicznego na tle niedoboru jodu pomimo, że od wielu lat istnieje program zwalczania wola głównie poprzez dodawanie jodu do soli kuchennej. Obecnie istnieje w Wietnamie program zwalczania niedoborów żywieniowych, który polega m.in. na promocji systemu WAC (ogród — staw rybny — hodowla zwierząt) w gospodarstwach domowych na wsi. Jego głównym celem jest urozmaicenie dziennej racji pokarmowej ludności oraz wdrażanie programu profilaktyki niedoboru witaminy A i kseroftalmii.
Methicillin-resistant Staphylococcus aureus (MRSA) strains with inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype may lead to clinical failure during clindamycin (CLI) therapy. The aim of this study was to determine the incidence of MLS|t phenotypes by using D-test method and genotypes by using multiplex real-time PCR method in MRSA strains. A total of 265 MRSA strains were obtained from clinical samples from hospitalized and outpatients. Of the MRSA isolates, 225 (84.9%) were resistant to erythromycin (ERT), and 170 (64.1%) to CLI. Among the 225 ERT-resistant MRSA strains, the constitutive MLS|f (cMLSu) rate was found in 49.3%, iMLSB in 39.1% and the M phenotype in 11.5%. Overall, ermA, ermC, ermA+ermC, msrA, ermC+msrA, and ermA+ermC+msrA genes were detected in 85 (37.7%), 60 (26.6%), 42 (18.6%), 26 (11.5%), 11 (4.8%), and 1 (0.4%) isolates, respectively. Most prevalent resistance determinant in MRSA strains was ermA", which was detected in 37.7% of the isolates. The 26 MRSA strains with M phenotype harboured only msrA gene. In conclusion, due to aware of the potential of CLI treatment failure, D-test should be performed and reported in MRSA strains in clinical laboratories. The multiplex real-time PCR method is easy to perform, fast and reliable method for the detection of MLSB resistance genotypes.
The study on the prevalence of overweight and obesity involved 3181 women doing mental and physical work. In studied women body height and weight were measured and BMI was calculated to estimate if they were overweight or obese. The per cent of women with overweight and obesity increased with age in both groups. The prevalence of these abnormalities was more frequent in physical workers than in women doing mental work. Overweight and obesity were connected also with the place of residence and tobacco smoking.
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