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Mechanisms of vasorelaxation induced by total flavonoids of Euphorbia humifusa in rat aorta

100%

Wang T. T., Zhou Z. Q., Wang S., Ji X. W., Wu B., Sun L. Y., Wen J. F., Kang D. G., Lee H. S., Cho K. W., Jin S. N.

Journal of Physiology and Pharmacology

2017

tom 68

nr 4

Mantidis ootheca induces vascular relaxation through PI3K/Akt-mediated nitric oxide-cyclic GMP-protein kinase G signaling in endothelial cells

80%

Kim H. Y., Lee Y. J., Han B. H., Yoon J. J., Ahn Y. M., Hong M. H., Tan R., Kang D. G., Lee H. S.

Journal of Physiology and Pharmacology

2017

tom 68

nr 2

Physiology and pathophysiology of vascular signalling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase

80%

Birschmann I., Walter U.

Acta Biochimica Polonica

2004

tom 51

nr 2

Recent medical advances suggest that the cellular natriuretic peptide/cGMP and NO/cGMP effector systems represent important signal transduction pathways especially in the cardiovascular system. These pathways also appear to be very interesting targets for the possible prevention of cardiovascular diseases. Exciting candidates for prevention include cGMP-dependent signaling networks initiated by natriuretic peptides (NP) and nitric oxide (NO) which are currently explored for their diagnostic and therapeutic potential. cGMP signaling contributes to the function and interaction of several vascular cell types, and its dysfunction is involved in the progression of major cardiovascular diseases such as atherosclerosis, hypertension and diabetic complications. This review will take a focussed look at key elements of the cGMP signaling cascade in vascular tissue. Recent advances in our knowledge of cGMP-dependent protein kinases (cGK, also known as PKG), the potential for assessing the functional status of cGMP signaling and the possible cross talk with insulin signaling will be reviewed.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Acta Biochimica Polonica

2 Kang D. G.

2 Lee H. S.

1 Ahn Y. M.

1 Birschmann I.

1 Cho K. W.

1 Han B. H.

1 Hong M. H.

1 Ji X. W.

1 Jin S. N.

1 Kim H. Y.

1 Lee Y. J.

1 Sun L. Y.

1 Tan R.

1 Walter U.

1 Wang S.

1 Wang T. T.

1 Wen J. F.

1 Wu B.

1 Yoon J. J.

1 Zhou Z. Q.

2 2017

1 2004

Wyniki wyszukiwania

Mechanisms of vasorelaxation induced by total flavonoids of Euphorbia humifusa in rat aorta

Mantidis ootheca induces vascular relaxation through PI3K/Akt-mediated nitric oxide-cyclic GMP-protein kinase G signaling in endothelial cells

Physiology and pathophysiology of vascular signalling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase