Wyniki wyszukiwania - AGRO

1

Autofagia w przebudowie gruczolu mlekowego bydla

100%

Gajewska M., Gajkowska B., Sobolewska A., Motyl T.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 11 Supl.

1412-1416

Autophagy is a process responsible for the degradation and recycling of cytoplasmic content by lysosomes. It is thought to facilitate cell survival during periods of nutrient starvation, but it can also be involved in other physiological processes including regulation of protein homeostasis, degrading intracellular bacteria, tumor suppression and regulation of programmed cell death. Our group was the first to report autophagy in bovine mammary epithelial cells, both in vitro, on BME-UV1 mammary epithelial cell line, and in vivo. The highest intensity of autophagy in bovine mammary glands is noted during dry periods, when the gland undergoes intensive involution and the deprivation of bioactive compounds (hormones, growth factors, cytokines) and nutrients occur. Our studies on the regulation of autophagy show that the conditions observed during bovine mammary gland involution, such as: 1) decrease in the release of lactogenic hormones and growth factors (prolactin, GH and IGF-I); 2) increase of apoptogenic factors (i.e. TGF-β₁) and their receptors, 3) increased synthesis of sex steroids (17-β estradiol, progesterone); and 4) the enhanced competition of intensively developing fetus and mother organism for nutritional and bioactive compounds, may create a state of temporary malnutrition of mammary epithelial cells that forces the cells to the induction of autophagy as a mechanism stabilizing intracellular supplies of energy and aminoacids, especially during the enhanced activity of apoptogenic factors.

2

Morfologiczne i molekularne wskazniki komorek macierzystych i progenitorowych w gruczole sutkowym

100%

Kolek O., Gajkowska B., Motyl T.

Medycyna Weterynaryjna

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2008

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tom 64

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nr 02

136-141

The mammary gland is a dynamic organ that undergoes profound remodeling dependent on proliferation, differentiation, and apoptosis of mammary epithelial cells (MEC) during the cycle of the pregnancy, lactation, and involution. Long-lived populations of stem cells, which have a unique capacity for self-renewal, are responsible for these developmental changes. There is an increasing body of discoveries regarding human and mouse mammary gland stem cells, but the studies on bovine mammary gland stem cells are still very limited. According to morphological criteria bovine MEC are classified into two types: undifferentiated type I stem/progenitor cells assembling small light cells (SLC) and large light cells (LLC), and type II partially differentiated large dark cells (LDC) and terminally differentiated cells. To date there are no identified reliable molecular markers of stem/progenitor cells in bovine mammary glands. The main candidates are membrane transporting proteins of the Adenosine Binding Cassette (ABC) family, including Multi-drug-resistance protein 1 (Mdr1) and Breast cancer resistance protein 1 (Bcrp1). These proteins allow for the isolation of side populations (SP) of MEC assembling stem/progenitor cells by exclusion of dyes. Cytometric analysis of SP revealed from 0.2% to 5% of MEC in human and mouse mammary glands. The knowledge on the number and molecular properties of stem cells in bovine mammary glands would be very useful not only for enhancing milk production but also for explanation of the natural resistance against mammary cancer in this species.

3

Rola genow homeotycznych w rozwoju gruczolu mlecznego.

100%

Malewski T.

Postępy Biologii Komórki. Suplement

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2001

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tom 18

137-142

4

Molekularne mechanizmy regulacji transkrypcji genow kodujacych bialka mleka

88%

Malewski T.

Prace i Materiały Zootechniczne. Monografie i Rozprawy

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2006

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nr 15

1-111

5

Wplyw doju mechanicznego na stan zdrowia gruczolu mlekowego krow

88%

Glazer T.

Hodowca Bydła i Trzody Chlewnej

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2003

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nr 01

9-13

6

Przydatnosc Terenowego Odczynu Komorkowego [TOK] do oceny stanu zdrowotnego gruczolu mlekowego koz

88%

Kalinowska B.

Zeszyty Naukowe Wydziału Zootechniki. Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

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1997

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tom 01

195-196

7

Inwolucja gruczolu mlekowego u krowy

88%

Malinowski E.

Medycyna Weterynaryjna

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2005

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tom 61

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nr 09

968-971

8

Zastosowanie technik hodowli przestrzennych [3D] w badaniach biologii gruczolu mlekowego bydla

88%

Kozlowski M., Motyl T.

Medycyna Weterynaryjna

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2007

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tom 63

|

nr 11 Supl.

1417-1420

The mammary gland has been extensively studied for over a century. However, the major contribution to our current knowledge of mammary gland biology has been made mostly by studying the mammary gland of humans and rodents, while ruminant models have lagged behind. During the last years, a variety of in vitro approaches have been employed to understand the regulation of mammary gland growth and morphogenesis during different developmental and physiological stages. There are only a few immortalized cell lines of bovine mammary gland epithelium. Unfortunately only three of them are IGF and EGF sensitive, which is very important in mammary gland development in vivo. Monolayer culture models are easy and convenient to set up but they lack the three-dimensional microenvironment of intact tissue. This review describes the three-dimensional (3-D) cell culture system, which has recently been widely used. Bovine primary mammary epithelium cell cultures and some immortalized cell lines plated on an extracellular matrix form functional acini-like structures. This model mimics organization and differentiation of an intact tissue and can be very useful in the investigation of bovine mammary gland biology.

9

Wystepowanie i profilaktyka zakazen i zapalen gruczolu mlekowego u jalowek

88%

Vasil M., Zapletal P.

Prace i Materiały Zootechniczne

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2008

|

tom 65

121-126

10

Metabolizm w gruczole mlekowym przezuwaczy oraz metody pomiaru przeplywu krwi przez gruczol mlekowy

88%

Krol H., Urbaniak M.

Roczniki Naukowe Zootechniki. Suplement

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2000

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nr 09

91-95

11

Profilaktyka zapaleń gruczołu mlekowego

75%

Brzozowska J.

Przegląd Mleczarski

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2013

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nr 03

12

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Obserwacje nad związkiem między zdolnością wydojową a zapadalnością krów na mastitis

75%

Ryniewicz Z.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1978

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tom 207

13

Wartość diagnostyczna badania cytologicznego mleka, pomiarów aktywności katalazy i gamma-glutamylotranspeptydazy (GGTP) w rozpoznaniu chorób gruczołu mlecznego u loch

75%

Samborski Z., Poznanski W.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1974

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tom 153

14

Fizjologiczne i zdrowotne aspekty laktacji u loch

75%

Rekiel A.

Postępy Nauk Rolniczych

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2006

|

tom 53

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nr 2

23-33

15

Trojwymiarowe hodowle komorek nablonka gruczolu sutkowego jako model badawczy procesu roznicowania

75%

Gajewska M., Kozlowski M., Motyl T.

Postępy Biologii Komórki

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2010

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tom 37

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nr 1

121-135

16

Charakterystyka stanu zdrowotnego gruczolow mlekowych maciorek rasy wrzosowka

75%

Siudek T., Swiderek W. P.

Zeszyty Naukowe. Przegląd Hodowlany

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1996

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tom 23

171-175

17

Aferentne unerwienie gruczolu sutkowego suki

75%

Boratynski Z., Flieger S., Zacharko A., Strzalka B., Arciszewski M., Matysek M.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2003

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tom 02

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nr 1

3-10

18

Niezłośliwe zmiany patologiczne w strukturze komórkowej gruczołu sutkowego suk

75%

Katkiewicz M.

Życie Weterynaryjne

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2014

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tom 89

|

nr 02

19

Badania nad częstotliwością i stopniem zapalenia wymion u krów użytkowanych w fermach przemysłowych

75%

Kijak Z., Groth I., Puchajda Z., Wronski M.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1978

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tom 207

20

Biogeneza kuleczek tłuszczowych mleka

75%

Smoczynski M., Staniewski B., Kielczewska K.

Medycyna Weterynaryjna

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2012

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tom 68

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nr 03

Processes of milk fat biosynthesis and milk fat globules secretion are gaining increasing attention in recent years. Milk fat not only provides calories and nutritionally important components, but also greatly contributes to the organoleptic characteristics of dairy products. Milk fat globules are formed and secreted from mammary epithelial cells. The functioning and development of the mammary gland is a very complex process. The changes in hormonal levels upon each pregnancy cause the mammary epithelial cells to proliferate, differentiate and die due to apoptosis. The paper brings together current information regarding the regulation of the mammary gland development, regulation of milk fat synthesis, as well as characterizes key stages in the biosynthesis, formation and secretion of milk fat globules.

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