Wyniki wyszukiwania - AGRO

1

Crosstalk between G protein-coupled receptors and tyrosine kinase signalling; Src take centre stage

100%

Ptasznik A., Gewirtz A. M.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

|

nr 1

2

Regulation of bovine intra-luteal function by peptide hormones

88%

Schams D.

Journal of Physiology and Pharmacology. Supplement

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1992

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tom 43

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nr 1

3

Rescue of sympathetic neurons from NGF-withdrawal apoptosis by adenosine

88%

Wakade A. R., Wakade T. D., Przywara D. A.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

4

Alterations in morphology of REF cells induced by growth factors produced by ASV - transformed [GCA] cells

88%

Szuster A., Kosz-Vnenchak M.

Folia Histochemica et Cytobiologica

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1993

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tom 31

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nr 1

5

Specific, irreversible inhibitors of the epidermal growth factor receptor [EGFR] family of tyrosine kinases

88%

Fry D. W.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

6

Purification of autocrine growth factor from conditioned medium of rat sarcoma [XC] cells

88%

Checiowna D., Klein A.

Folia Histochemica et Cytobiologica

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1996

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tom 34

|

nr 3-4

7

Growth factors related to some herpes viruses

88%

Golais F., Lesko J., Gasperik J.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

8

Growth factors in the initial stage of bone formation, analysis of their expression in chondrocytes from epiphyseal cartilage of rat costochondral junction

75%

Hyc A., Moskalewski S., Osiecka-Iwan A.

Folia Histochemica et Cytobiologica

|

2021

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tom 59

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nr 3

9

Growth factors effects on preimplantation development of mouse embryos exposed to tumor necrosis factor alpha

75%

Glabowski W., Kurzawa R., Wiszniewska B., Baczkowski T., Marchlewicz M., Brelik P.

Reproductive Biology

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2005

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tom 05

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nr 1

10

Chromosomal assignment of R-spondin genes in the donkey (Equus asinus, 2n equals 62)

75%

De Lorenzi L., Genualdo V., Perucatti A., Pia Di Meo G., Molteni L., Iannuzzi L., Parma P.

Journal of Applied Genetics

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2010

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tom 51

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nr 3

R-spondins constitute a recently discovered small family of growth factors, and the evidence of their role in several developmental pathways is growing fast. In this work we describe the chromosomal location of the four RSPO genes in the donkey. Using horse BACs, we localized RSIPO1 on EAS 5q23, RSPO2 on EAS 12q13, RSPO3 on EAS 24q26, and RSPO4 on EAS 15p13. Moreover, RSPO2, RSPO3, and RSPO4 are the first genes mapped on donkey chromosomes 12, 24, and 15, respectively.

11

Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis

75%

Kimura H., Esumi H.

Acta Biochimica Polonica

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2003

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tom 50

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nr 1

Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypo- xia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca2+ /calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.

12

The role of nitric oxide synthase, superoxide dismutase and heme oxygenase-1 in the synthesis of vascular endothelial growth factor

75%

Dulak J., Grzenkowicz J., Cisowski J., Podhajska A., Jozkowicz A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

13

On the role of integrin-induced signalling in Rac activation; involrement of cytoskeletal and signalling molecules

75%

Bialkowska K., Fox J. E. B.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

14

Immunocytochemical evaluation of differentiation markers on human keratinocytes in various culture conditions

75%

Saczko J.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

|

nr 2

15

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Modulation of gastric mucosal calcium channels activity by platelet-derived growth factor

75%

Slomiany B. L., Liu J., Fecete Z., Piotrowski J., Slomiany A.

Journal of Physiology and Pharmacology

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1992

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tom 43

|

nr 4

A dihydropyridine-sensitive gastric mucosal calcium channels were isolated from the solubilized epithelial cell membranes by affinity chromatography on wheat germ agglutinin. The channels following labeling the calcium antagonist receptor site with [³H]PN200-100 were reconstituted into phospholipid vesicles which exhibited active ⁴⁵Ca²⁺ uptake as evidenced by La³⁺ displacement assays. The uptake of calcium was independent of sodium and potassium gradients indicating the electroneutral nature of the process. The channels responded in a dose dependent manner to dihydropyridine calcium antagonist, PN200-110, which at 0.5/zm exerted maximal inhibitory affect of 66% on ⁴⁵Ca²⁺ uptake, while a 52% enhacement in ⁴⁵Ca²⁺ uptake occurred with a specific calcium channel activator, BAY K8644. On platelet-derived growth factor (PDGF) binding in the presence of ATP, channel protein showed an increase in tyrosine phosphorylation of 55 and 170 kDa calcium channel proteins. Such phosphorylated channels following reconstitution into vesicles displayed a 78% greater ⁴⁵Ca²⁺ uptake. The results demonstrate the importance of PDGF in the regulation of gastric mucosal calcium uptake.

16

Effect of epidermal growth factor [EGF] on Tetrahymena pyriformis

75%

Kohidai L., Keresztesi M., Csaba G.

Acta Protozoologica

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2001

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tom 40

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nr 3

17

Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor

75%

Funa K., Uramoto H.

Acta Biochimica Polonica

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2003

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tom 50

|

nr 3

PDGF is one of the most potent serum mitogens, and the signalling mechanism by way of its receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in various tumours and stroma led to the proposal of the PDGF-mediated autocrine and paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival of cells, the expression and activity of PDGF receptors are tightly controlled by both positive and negative feedback mechanisms at different levels. The deregulation of the control system can result in serious pathological conditions such as chronic inflammation and tumours. Understanding the molecular mechanisms for the regulatory system and the signalling pathway of PDGF is essential in order to find effective therapies in the diseases where PDGF is involved.

18

Immunomodulatory activity of conformationally restricted peptides related to TGF-beta2 90-99 sequence

75%

Wieczorek Z., Slon J. I., Siemion I. Z.

Archivum Immunologiae et Therapiae Experimentalis

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1996

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tom 44

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nr 4

19

Autologous cord blood transfusion in preterm infants - could its humoral effect be the key to control prematurity-related complications? A preliminary study

63%

Kotowski M., Litwinska Z., Klos P., Pius-Sadowska E., Zagrodnik-Ulan E., Ustianowski P., Rudnicki J., Machalinski B.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 6

20

Prostaglandins and ulcer healing

63%

Konturek S. J., Konturek P. C., Brzozowski T.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 5

5-31

Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory doses that appear to enhance COX-2 expression and PGE2 generation in the ulcer area. COX-1 and COX-inhibitors delay ulcer healing, particularly when both COX isoforms are suppressed such e.g. by indomethacin. Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE2, delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE2. Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa. Endogenous PG generated at ulcer margin appear to be involved in ulcer healing promoted by growth factors and gut hormones such as gastrin or CCK and melatonin acting, at least in part, through increase of induction of COX-2 and local release of PGE2 in the ulcer area . The ulcer healing activity of growth factors (e.g. EGF, TGFalpha, HGF) and certain gut hormones (gastrin, CCK) as well as melatonin, can be attenuated by treatment with COX-1 or COX-2 inhibitors which suppress the release of PGE2 but enhance the expression of COX-2. It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.

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