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A group of 173 obese men with asymptomatic hyperuricaemia or gout was observed. 123 of them were treated with low-purine low-calorie diet (LPLCD) in a hospital ward for 21 days. 50 patients (a control group) were put on an ordinary low-caloric diet (LCD). The results showed the evident hypouricaemic effect of LPLCD, The serum uric acid decreased by 25% in patients with asymptomatic hyperuricaemia and by 18% in the gouty patients. Body mass and serum lipids concentration were also significantly reduced. The nitrogen balance, negative at the beginning of the diet, was normalized at the end of treatment. LPLCD is recommended as a principal method in treatment of purine metabolism disturbances in obese hyperlipaemic patients.
In a group of 129 obese men and women asymptomatic hyperuricaemia was found in 49 and gout in 30 patients. Moderate positive correlation between serum uric acid level and body mass index was observed. Serum uric acid level was higher in all groups of obese patients than in the control group. The mean rate clearance was significantly decreased in obese patients with hyperuricaemia and gout. The most prevalent was the metabolic type of hyperuricaemia found in 58% of males and in 43% of females, followed by the mixed type (in 27% of males and in 29% of females). The renal type of hyperuricaemia was found in 15% of men and 28% of women. A significant increase in beta2-microglobulin in serum and urine of patients with hyperuricaemia and gout was determined by the radioimmunologic test. These results point to the incipient kidney lesions.
The aim of the study was to evaluate the prevalence of hyperuricaemia and gout in the population of the Tychy urban agglomeration that is only moderately exposed to ecotoxins. Energy expenditure during professional work and dietary habits were taken into account. The study was carried out in 1957 subjects, including 1391 men and 566 women, divided into 5 groups differing in the physical activity connected with their work. In all subjects the serum uric acid level was determined, what enabled isolating cases with hyperuricaemia and gout. The evaluation of dietary habits was performed. The prevalence of hyperuricaemia was found to be 37.9% in the whole population studied, and that of gout was 2.4% in men and 2.5% in women. The occupational physical activity decreased the serum uric acid level. High-calorie diet was a risk factor for hyperuricaemia.
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