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1

The course of the glucose tolerance curve in rats infected with Nippostrongylus brasiliensis

100%

Stpiczynska R.

Acta Parasitologica

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1992

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tom 37

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nr 1

The effect of Nippostrongylus brasiliensis infection (3000 larvae) on the course of the glucose tolerance curve in rats was investigated. On the 4th and 9th day after infection (DAI) rats displayed severe fasting hypoglycemia. Following oral glucose administration after 30 min this sugar appeared in blood of all rats: controls and infected ones (4 and 9 DAI) at a similar rate; however, the glucose tolerance curves of the infected rats, in contrast to controls, failed to reach maximal values after 30 min from the time of oral glucose administration. The infected and control rats exhibited an approximately similar blood glucose concentration only after 150 min from this administration. The results presented indicate that in rats infected with N. brasiliensis the glucose requirement is increased; malabsorption exerts no effext on the course of the glucose tolerance curves, and glucose deficiencies are compensated only after a lapse of a sufficiently long period (150 min) after glucose administration.

2

Essentiality of chromium for human nutrition and health

88%

Krejpcio Z.

Polish Journal of Environmental Studies

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2001

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tom 10

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nr 6

The aim of this paper is to review current knowledge about the essentiality of trivalent chromium for animal and human nutrition, and its biological function with special reference to its role in carbohydrate and lipid metabolism, dietary intake and recommendations.

3

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Effects of saturated and polyunsaturated fat enriched diet on the skeletal muscle insulin sensitivity in young rats

75%

Budohoski L., Panczenko-Kresowska B., Langfort J., Zernicka E., Dubaniewicz A., Ziemlanski S., Challiss R. A. J., Newsholme E. A.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 4

4

Ambivalent role of gallated catechins in glucose tolerance in humans: A novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption

63%

Park J. H., Jin J. Y., Baek W. K., Park S. H., Sung H. Y., Kim Y. K., Lee J., Song D. K.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

101-109

Prolonged postprandial hyperglycemia is a detrimental factor for type 2 diabetes and obesity. The benefit of green tea extract (GTE) consumption still requires confirmation. We report the effects of circulating green tea catechins on blood glucose and insulin levels. Oral glucose loading 1 h after GTE ingestion in humans led to higher blood glucose and insulin levels than in control subjects. Gallated catechins were required for these effects, although within the intestinal lumen they have been known to decrease glucose and cholesterol absorption. Treatment with epigallocatechin-3-gallate hindered 2-deoxyglucose uptake into liver, fat, pancreatic beta-cell, and skeletal muscle cell lines. The glucose intolerance was ameliorated by gallated catechin-deficient GTE or GTE mixed with polyethylene glycol, which was used as an inhibitor of intestinal absorption of gallated catechins. These findings may suggest that the gallated catechin when it is in the circulation elevates blood glucose level by blocking normal glucose uptake into the tissues, resulting in secondary hyperinsulinemia, whereas it decreases glucose entry into the circulation when they are inside the intestinal lumen. These findings encourage the development of non-absorbable derivatives of gallated catechins for preventative treatment of type 2 diabetes and obesity, which would specifically induce only the positive luminal effect.

5

Effect of 17beta-estradiol on glucose tolerance and plasma insulin concentration in anestral sheep

51%

Wojcik M., Bobowiec R., Klimont M., Tusinska E.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2005

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tom 08

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nr 4

6

Metformin-induced regulation of the intestinal D-glucose transporters

51%

Sakar Y., Meddah B., Faouzi M. A., Cherrah Y., Bado A., Ducroc R.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 3

301-307

Metformin is an orally administered drug that lowers blood glucose and improves insulin sensitivity in patients with non insulin-dependent diabetes. Although the antihyperglycemic effect of metformin has been extensively studied, its cellular mechanism(s) of action (including the effect on enterocyte) remains to be defined. This study was designed to examine the effect of metformin on glucose transporters in enterocyte. Na+-dependent glucose transporter-1 (SGLT-1) activity was followed as glucose-induced short-circuit current (Isc) in Ussing chambers. The effect of metformin (10 µmol/L, 3 min) on transmural glucose transport was studied in isolated rat jejunal loops. Its impact on abundance of transporters SGLT-1 and GLUT2 in jejunal brush border membranes (BBM) and its effect on the phosphorylation of AMP-activated protein kinase (AMPK) 2 subunit was studied by western blot. Acute effect of metformin was also measured in vivo by oral glucose tolerance test (OGTT). Metformin markedly inhibited glucose-induced Isc (~77%) after mucosal addition. In addition, metformin reduced the glucose-induced abundance of SGLT-1 in BBM and increased those of GLUT2, concomitantly increasing the phosphorylation of intracellular AMPK2. This effect of metformin was also observed using non-metabolizable sugar 3-O-methyl glucose. Transmural glucose transport measured in vitro was increased by 22% under metformin. Finally, oral metformin markedly increased glucose tolerance in OGTT. In conclusion, metformin slightly increases intestinal glucose absorption by inducing a re-distribution of glucose transporters in BBM through AMPK control in enterocyte. In addition to its action to other splanchnic tissues, this could constitute a peripheral signal contributing to the beneficial effect of metformin on glucose tolerance.

7

Relationship between certain parameters included in the glucose tolerance test in young heifers and their milk production traits in forthcoming lactation I

51%

Fiedorowicz S., Strzalkowska N., Bagnicka E., Jozwik A., Krzyzewski J., Reklewski Z.

Animal Science Papers and Reports

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2008

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tom 26

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nr 2

The aim of the study was to establish the relationship between parametres included in the glucose tolerance test (GTT) of heifers aged 9-10 months and their subsequent milk yield and composition in lactation I. Used were 42 Holstein-Friesian heifers selected from the herd with a mean individual yield of 9600 kg milk/year with 4.32% fat and 3.44% protein. Over 24 hrs preceding the GTT the animals were offered only water and small amount of hay. After that time a “0” blood sample was withdrawn from each heifer and animals were infused intravenously with 40% water solution of glucose (the volume applied was equivalent to 1g glucose/kg W0.75). Then nine blood samples were withdrawn at 6 min intervals, and glucose and insulin contents of serum were determined.After calving, the heifers were maintained under uniform conditions and fed according to TMR system (INRA feeding standards) till the end of lactation I. Simple correlation coefficients were calculated between the area under the glucose and under insulin concentration curves (AGLUCC and AINSCC), ratio AGLUCC/AINSCC (GLIN combined index), maximum glucose concentration (GLUMAX) and maximum insulin concentration (INSMAX). Moreover, coefficients of regression were calculated of the GTT individual indicators on milk production traits and respective regression equations were derived. The GLIN index appeared to be the most suitable GTT parametre to predict future milk traits in dairy heifers. It can be anticipated that GTT may be employed in practical breeding work as an additional criterion of preliminary selection of heifers assigned for dairy herd replacement.

8

Nutritional habits among hypertensive patients with normal glucose tolerance [NGT] and impaired glucose tolerance [IGT] - a pilot study

51%

Gajewska D., Niegowska J., Tomaszek K.

Polish Journal of Food and Nutrition Sciences

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2006

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tom 15/56

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nr Spec.Issue 2

The aim of our study was to estimate the intakes of energy and macronutrients by patients with hypertension and normal (NGT) or impaired glucose tolerance (IGT). Thirty six patients with medically treated essential hypertension, 18 with NGT and 18 with IGT, were included in the study. Over 80% of individuals with NGT and 70% with IGT were overweight or obese, and approximately 60% of them had waist circumferences confirming the presence of abdominal obesity. More than 70% of patients had metabolic syndrome traits in both, NGT and IGT group. Low energy intake (20 kcal/kg BW), normal protein and fat intakes (0.9-1.1 g/kg BW and 0.8-0.9 g/kg BW, respectively) and appropriate carbohydrates intake (45-48% of total energy) were observed among patients. There were no significant differences in energy and nutrients intake between NGT and IGT subjects, except for protein density and percentage of energy from protein. To prevent or delay diabetes, nutrition counseling for IGT patients, as well as monitoring of the adherence to a healthy life style, should be considered.

Ograniczanie wyników

The course of the glucose tolerance curve in rats infected with Nippostrongylus brasiliensis

Essentiality of chromium for human nutrition and health

Effects of saturated and polyunsaturated fat enriched diet on the skeletal muscle insulin sensitivity in young rats

Ambivalent role of gallated catechins in glucose tolerance in humans: A novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption

Effect of 17beta-estradiol on glucose tolerance and plasma insulin concentration in anestral sheep

Metformin-induced regulation of the intestinal D-glucose transporters

Relationship between certain parameters included in the glucose tolerance test in young heifers and their milk production traits in forthcoming lactation I

Nutritional habits among hypertensive patients with normal glucose tolerance [NGT] and impaired glucose tolerance [IGT] - a pilot study