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1

Glucagon-like peptides in the CNS of man: localization and possible functional importance

100%
Bernstein H. G.
Folia Histochemica et Cytobiologica
|
1984
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tom 22
|
nr 3-4
2
Content available remote

Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity

100%
Yang Y., Cui X., Chen Y., Wang Y., Li X., Lin L., Zhang H.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 3
3
Content available remote

Interactions between leptin and exendin-4, a glucagon-like peptide-1 agonist, in the regulation of food intake in the rat

100%
Bojanowska E., Nowak A.
Journal of Physiology and Pharmacology
|
2007
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tom 58
|
nr 2
Leptin interplays with other peptides to control feeding behaviour in humans and animals. Using exendin-4, an agonist of glucagon-like peptide-1, we investigated whether leptin modifies its effect on food intake in the rat. In the first series, exendin-4 alone (0.1, 2 or 10 µg per rat), leptin alone (0.1, 2, 10 or 100 µg per rat) or exendin-4 and leptin together (0.1 + 0.1, 2 + 2, 10 + 10, or 2 + 100 µg per rat, respectively) were injected once intraperitoneally. In the second series animals were injected either with exendin-4 (2 µg) alone, leptin (10 µg) alone, or leptin (10 µg) + exendin-4 (2 µg) daily for 5 subsequent days. At the lowest dose used, leptin and exendin-4 injected once together, but not separately, reduced significantly a 24-hour food intake. When used in higher doses, however, leptin did not change the exendin-4-dependent suppressory effect on food consumption. No significant differences in food intake were seen between rats treated repeatedly with exendin-4 only and animals injected with both drugs. Hence, leptin and exendin-4 may act additively to inhibit appetite when present in low concentrations while, at high leptin doses, this effect is abolished. The lack of synergistic effects of exendin-4 and high leptin concentrations on food intake may explain, at least in part, mechanisms responsible for leptin resistance in subjects with hyperleptinaemia.
4
Content available remote

Alteration of peptidergic gut-brain signaling under conditions of obesity

84%
Kuhne S. G., Stengel A.
Journal of Physiology and Pharmacology
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2019
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tom 70
|
nr 5
5
Content available remote

Early-effect of bariatric surgery (Scopinaro method) on intestinal hormones and adipokines in insulin resistant Wistar rat

67%
Dib N., Kiciak A., Pietrzak P., Ferenc K., Jaworski P., Kapica M., Tarnowski W., Zabielski R.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 5
6
Content available remote

The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet

67%
Wierucka-Rybak M., Wolak M., Bojanowska E.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 4
7
Content available remote

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

67%
Ceranowicz P., Warzecha Z., Dembinski A.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 1
8
Content available remote

The effect of pregnane x receptor agonists on postprandial incretin hormone secretion in rats and humans

67%
Hukkanen J., Rysa J., Makela K. A., Herzig K.-H., Hakkola J., Savolainen M. J.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 6
9

Rola glukagonopodobnego peptydu-1 w regulacji wydzielania insuliny

59%
Borkiewicz P., Fabis M., Mackowiak P.
Acta Scientiarum Polonorum. Medicina Veterinaria
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2002
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tom 01
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nr 1
153-159
10

The results of prolonged action of GLP-1 on some metabolic parameters

59%
Borkiewicz P., Pawlak M., Mackowiak P.
Folia Biologica
|
2011
|
tom 59
|
nr 1-2
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