Wyniki wyszukiwania

1

Cis-regulatory regions responsible for suspensor-specific transcription

100%

Kawashima T., Wang X.-J., Bi Y., Weterings K., Goldberg R. B.

Acta Biologica Cracoviensia. Series Botanica. Supplement

|

2005

|

tom 47

|

nr 1

2

Developmental gene expression of antimicrobial peptide Protegrin-1 and effect of weaning on gene regulation of Protegrin-1 in piglets

86%

Han F. F., Wang Y. Z., Feng J., Guo J., Xu Z. R.

Journal of Animal and Feed Sciences

|

2007

|

tom 16

|

nr 1

86-95

3

Automated modelling of genetic control in Arabidopsis thaliana

86%

Bozek K., Gambin A., Wilczynski B., Tiuryn J.

Journal of Fruit and Ornamental Plant Research

|

2006

|

tom 14

|

nr Suppl.1

4

Ozone- and ethylene-induced regulation of a grapevine resveratrol synthase promoter in transgenic tobacco

86%

Grimmig B., Schubert R., Fischer R., Hain R., Schreier P. H., Betz C., Langebartels C., Ernst D., Sandermann H.

Acta Physiologiae Plantarum

|

1997

|

tom 19

|

nr 4

Stilbene synthases (STSs) are enzymes that play a critical role in the biosynthesis of stilbene, phytoalexins in a small number of unrelated plant species, and are induced by various biotic and abiotic stressors like pathogen attack, UV-irradiation or ozone exposure. To investigate the molecular basis for ozone-induced plant stress responses, we have examined the promoter of the grapevine resveratrol synthase (Vst1). In this report we summarize the influence of ozone on gene regulation. In transgenic tobacco a chimeric gene construct, containing the Vst1 promoter combined with the β-glucuronidase (GUS) reporter gene, is rapidly induced by ozone (0.1 µl·l⁻¹, 12 h). The same construct is also strongly induced by ethylene (20 µl·l⁻¹, 12 h). Promoter deletion analysis of the 5′ flanking sequence identified a positive regulatory element between −430 bp and −280 bp. This region contains ethylene-responsive enhancer elements, as well as an elicitor-responsive sequence in inverse orientation.

5

Molecular phylogenetics of DNA 5mC-methyltransferases

86%

Bujnicki J. M., Radlinska M.

Acta Microbiologica Polonica

|

1999

|

tom 48

|

nr 1

6

Profiling of regulatory microRNA transcriptomes in various biological processes: a review

72%

Shah A. A., Meese E., Blin N.

Journal of Applied Genetics

|

2010

|

tom 51

|

nr 4

A class of small, non-coding ribonucleic acids, termed microRNA (miRNA), has recently emerged as a new key player in the cellular control of gene expression. By either blocking translation or inducing target mRNA degradation, miRNA not only participates in regular biological processes within cells and tissues but is also involved in pathological processes. Many human malignancies have been linked to specific miRNA expression patterns, raising hopes for new approaches to therapy. While such human disease-related mechanisms have been widely discussed and frequently reviewed, miRNA's general significance in animals has been less in editorial focus, despite its obvious role in basic physiological processes, e.g. neurosensory maturation, development of fertility, and hibernation. Using selected examples, this review highlights our current knowledge of miRNA's potential and its promise as a new tool for gene regulation.

7

The chicken alpha- and beta-globin gene domains and their chromatin organization

72%

Recillas-Targa F.

Cellular and Molecular Biology Letters

|

2000

|

tom 05

|

nr 4

451-467

The eukaryotic genome is organized into discrete chromatin domains. The globin groups of genes have been two of the classical biological systems to study the relationship between gene regulation and chromatin structure during development. The individual promoters, enhancers and silencers of the globin genes are stage- and tissue-specific regulatory elements that are controlled by the interaction of ubiquitous and erythroid nuclear factors. Such regulated activation requires an optimal chromatin organization. Erythroid and constitutive DNase I hypersensitive sites (DHs) contribute to chromatin domain remodeling mediated by locus control region (LCR) activity and defined by domain boundaries. A comparative analysis of the chicken α-and β-globin domains will outline the relevance and effect of chromatin structure on gene regulation.

8

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Cis-, trans-, transcriptional regulation of the Arabidopsis thaliana gene AtTrxo1 and its response upon germination and to salt

72%

Ortiz-Espin A., Iglesias-Fernandez R., Martinez-Alcala I., Calderon A., Camejo D., Sevilla F., Carbonero P., Jimenez A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2013

|

tom 94

|

nr 2

9

Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion

72%

Lee B., Ahn C., Jeon B.-H., Jung E.-M., Yoo Y.-M., Jeung E.-B.

Journal of Physiology and Pharmacology

|

2019

|

tom 70

|

nr 1

10

Apoplastic ROS sensing and signalling

72%

Kangasjarvi J.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2013

|

tom 94

|

nr 2

11

Quantum and quantum-classical studies of phosphoryl-transfer mechanisms in model systems

72%

Grochowski P.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

12

PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis

72%

Drewnowska K. D., Craig M. R., Digiovanni S. R., McCarty J. M., Moorman A. F. M., Lamers W. H., Schoolwerth A. C.

Journal of Physiology and Pharmacology

|

2002

|

tom 53

|

nr 1

To identify the nephron segments expressing PEPCK in control and acidotic conditions, PEPCK mRNA was localized in rat kidney using the technique of reverse transcription and polymerase chain reaction (RT-PCR)in individual microdissected S1 , S2 , and S3 segments of the rat proximal tubule. In controls, the number of tubules expressing PEPCK mRNA was greatest in the S3 segment, moderate in the S2 segment, and least in the S1 segment of the proximal tubule. After NH4Cl feeding, strong signals for PEPCK mRNA were detected in all three proximal tubule segments. in situ hybridization demonstrated expression of PEPCK mRNA only in the medullary rays in controls. After NH4Cl, PEPCK mRNA was expressed throughout the cortex, confirming the RT-PCR results. These data demonstrate the ability of the rat kidney cortex to modulate the expression of PEPCK mRNA during metabolic acidosis by recruitment of additional cells in the proximal nephrons. Studies with cultured LLC-PK1-F + cells indicated that increased PEPCK gene transcription at acid pH required a cis -acting element (enhancer)in the more distal 5 ’ flanking region of the promoter.

13

Expression of interferon genes in trophoblast: its impact on pregnancy

72%

La Bonnardiere C., Lefevre F.

Biotechnologia

|

1996

|

nr 2

14

Present and future use of isotopes as shown in studies on calcium-binding proteins

72%

Kuznicki J.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

1998

|

tom 46

|

nr 3-4

15

STAT activation and differential complex formation dictate selectivity of interferon responses

72%

Wesoly J., Szweykowska-Kulinska Z., Bluyssen H. A. R.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr 1

Interferons (IFNs) induce gene expression by phosphorylating latent transcription factors belonging to the signal transducer and activator of transcription (STAT) family, mediated by janus kinases (Jaks). STAT dimers directly activate genes containing the IFNγ activation site (GAS) DNA element, with different STAT proteins displaying slightly different intrinsic DNA binding specificities. The combinatorial association of STATs with the additional DNA binding adaptor protein interferon regulatory factor (IRF)9 expands the range of enhancer elements that can be targeted by the JAK-STAT pathway to interferon-stimulated response element (ISRE) and IRF response element (IRE). Based on the amino-acid sequence similarity within the IRF family and functional overlap with the STAT family, in this paper we hypothesize that other IRF members could serve as adapter proteins for the STATs during IFN responses to redirect them to subsets of ISRE, GAS and/or IRE-containing IFN-stimulated genes (ISGs). In addition, the fact that STAT2 homodimers are not capable of binding consensus GAS sites leaves the possibility for a novel type of DNA-binding site bound by STAT2 homodimers and potentially other STAT complexes.

16

Control of calcitonin gene expression in thyroid parafollicular cells co-cultured with thyroid follicular cells

72%

Zabel M., Gebarowska E., Kasprzak A.

Folia Histochemica et Cytobiologica

|

1999

|

tom 37

|

nr 2

17

WDR5, ASH2L, and RBBP5 control the efficiency of FOS transcript processing

58%

Teoh P. L., Sharrocks A. D.

Cellular and Molecular Biology Letters

|

2014

|

tom 19

|

nr 2

H3K4 trimethylation is strongly associated with active transcription. The deposition of this mark is catalyzed by SET-domain methyltransferases, which consist of a subcomplex containing WDR5, ASH2L, and RBBP5 (the WAR subcomplex); a catalytic SET-domain protein; and additional complexspecific subunits. The ERK MAPK pathway also plays an important role in gene regulation via phosphorylation of transcription factors, co-regulators, or histone modifier complexes. However, the potential interactions between these two pathways remain largely unexplored. We investigated their potential interplay in terms of the regulation of the immediate early gene (IEG) regulatory network. We found that depletion of components of the WAR subcomplex led to increased levels of unspliced transcripts of IEGs that did not necessarily reflect changes in their mature transcripts. This occurs in a manner independent from changes in the H3K4me3 levels at the promoter region. We focused on FOS and found that the depletion of WAR subcomplex components affected the efficiency of FOS transcript processing. Our findings show a new aspect of WAR subcomplex function in coordinating active transcription with efficient pre-mRNA processing.

18

Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

58%

Plata K., Rosato A. E., Wegrzyn G.

Acta Biochimica Polonica

|

2009

|

tom 56

|

nr 4

597-612

Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.

19

Analysis of selected toxic metals using bacterial biosensors and their macromolecular derivatives

58%

Bartos A.

Biotechnology and Food Science

|

2012

|

tom 76

|

nr 1

20

Survey of plant pigments: molecular and environmental determinants of plant colors

58%

Mlodzinska E.

Acta Biologica Cracoviensia. Series Botanica

|

2009

|

tom 51

|

nr 1

7-16

It is difficult to estimate the importance of plant pigments in plant biology. Chlorophylls are the most important pigments, as they are required for photosynthesis. Carotenoids are also necessary for their functions in photosynthesis. Other plant pigments such as flavonoids play a crucial role in the interaction between plants and animals as visual signals for pollination and seed scattering. Studies related to plant pigmentation are one of the oldest areas of work in plant science. The first publication about carotenoids appeared in the early nineteenth century, and the term "chlorophyll" was first used in 1818 (Davies, 2004). Since then, the biochemical structure of plant pigments has been revealed, as have the biosynthetic pathways for the major pigments that provide a useful variety of colors to blossoms and other plant organs. There is widespread interest in the application of molecular methods to improve our knowledge of gene regulation mechanisms and changes in plant pigment content. Genetic modification has been used to alter pigment production in transgenic plants. This review focuses on flower pigmentation, its biochemistry and biology. It presents a general overview of the major plant pigment groups as well as rarer plant dyes and their diversity and function in generating the range of colors observed in plants.

Ograniczanie wyników

Cis-regulatory regions responsible for suspensor-specific transcription

Developmental gene expression of antimicrobial peptide Protegrin-1 and effect of weaning on gene regulation of Protegrin-1 in piglets

Automated modelling of genetic control in Arabidopsis thaliana

Ozone- and ethylene-induced regulation of a grapevine resveratrol synthase promoter in transgenic tobacco

Molecular phylogenetics of DNA 5mC-methyltransferases

Profiling of regulatory microRNA transcriptomes in various biological processes: a review

The chicken alpha- and beta-globin gene domains and their chromatin organization

Cis-, trans-, transcriptional regulation of the Arabidopsis thaliana gene AtTrxo1 and its response upon germination and to salt

Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion

Apoplastic ROS sensing and signalling

Quantum and quantum-classical studies of phosphoryl-transfer mechanisms in model systems

PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis

Expression of interferon genes in trophoblast: its impact on pregnancy

Present and future use of isotopes as shown in studies on calcium-binding proteins

STAT activation and differential complex formation dictate selectivity of interferon responses

Control of calcitonin gene expression in thyroid parafollicular cells co-cultured with thyroid follicular cells

WDR5, ASH2L, and RBBP5 control the efficiency of FOS transcript processing

Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

Analysis of selected toxic metals using bacterial biosensors and their macromolecular derivatives

Survey of plant pigments: molecular and environmental determinants of plant colors