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The low-FODMAP diet as an effective tool for managing irritable bowel syndrome – an assessment of adult patients’ knowledge of dietary guidelines

100%

Kostecka M., Kostecka-Jarecka J., Kowal M.

Roczniki Państwowego Zakładu Higieny

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2021

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tom 72

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nr 4

2

Molecular characterization of Giardia intestinalis detected in humans and water samples in Egypt

100%

El-Latif N. F. A., El-Taweel H. A., Gaballah A., Salem A. I., El-Malak A. H. M. A.

Acta Parasitologica

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2020

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tom 65

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nr 2

3

Azithromycin in the treatment of a dog infected with Giardia intestinalis

84%

Zygner W., Jaros D., Gojska-Zygner O., Wedrychowicz H.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 3

231-234

Giardia intestinalis infection is a common cause of diarrhoea in humans and other mammalian species throughout the world. This report describes a case of a dog suffering from diarrhoea, infected with G. intestinalis, effectively treated with azithromycin. Azithromycin is an azalide, semisynthetic macrolide antibiotic having a large spectrum of activity against bacterial pathogens and some protozoa. In this case, Giardia infection in a dog was confirmed by microscopic examination and PCR. Sequencing of the detected Giardia amplicon confirmed infection with assemblage A-I. The dog received azithromycin administered at dose of 10 mg/kg per os, once a day for 5 days. After the therapy, the diarrhoea stopped. Effectiveness of the treatment was also confirmed by PCR and microscopic examination. This is the first report on the therapy of canine giardiosis with azithromycin. It seems that azithromycin can be considered as promising antibiotic for the control of Giardia infection in dogs.

4

Probiotics in the treatment of gastrointestinal diseases

84%

Przerwa F., Kukowka A., Kotrych K., Uzar I.

Herba Polonica

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2021

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tom 67

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nr 2

5

The influence of anti-TNF therapy on CD31 and VEGF expression in colonic mucosa of Crohn’s disease patients in relation to mucosal healing

84%

Eder P., Lykowska-Szuber L., Iwanik K., Krela-Kazmierczak I., Stawczyk-Eder K., Majewski P., Linke K., Kay E. W., Wozniak A.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 2

6

Immunoinflammatory responses in gastrointestinal tract injury and recovery

84%

Verma G., Marella A., Shaquiquzzaman M., Alam M. M.

Acta Biochimica Polonica

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2013

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tom 60

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nr 2

Inflammation is a non-specific immune response to infection, irritation or other injury, the key features being redness, warmth, swelling and pain. A number of mediators are released which alter the resistance of mucosa to injury induced by noxious substances. Oxidative stress is a unifying mechanism of injury in many types of disease processes, including gastrointestinal diseases. It has been defined as an imbalance in the activity of pro and antioxidants. Pro-oxidants favour free radical formation while antioxidants inhibit or retard the same. A number of markers of oxidative stress have been identified. This review provides an overview of various mediators of inflammation and oxidative stress, and diverse approaches for prevention and treatment of gastrointestinal inflammation.

7

Bronchodilator, vasolidator and spasmolytic activities of methanolic extract of Myrthus communis L.

84%

Janbaz K. H., Nisa M., Saqib F., Imran I., Zia-Ul-Haq M., De Feo V.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 4

8

Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases

84%

Konturek P. C., Haziri D., Brzozowski T., Hess T., Heyman S., Kwiecien S., Konturek S. J., Koziel J.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 4

9

Contribution of epidemiology in Poland for better understanding of the natural history of diseases in gastrointestinal tract

84%

Jedrychowski W.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

|

nr 3

245-261

Descriptive epidemiologic studies on the geographical distribution of gastrointestinal diseases in Poland have been conducted in our country since several decades. One of the first descriptive analyses was cancer study in 1967, where age-standardized mortality rates in various regions of Poland by gender and area of residence (urban/rural) were presented. Since 1970 analytical epidemiologic studies aiming at explaining the natural course of various diseases within gastrointestinal tract started to produce interesting results. The first study in this field was the case-control study on the occurrence of peptic ulcer and tobacco smoking performed in 1974. The study provided one of the first epidemiologic evidence on the harmful effect of tobacco smoking in the etiology or peptic ulcers. Subsequent studies dealt with the importance of dietary habits and life style (tobacco smoking and vodka drinking) in the occurrence of gastric cancer. The studies confirmed previous findings that consumption of raw vegetables and fresh fruit is inversely related to risk for stomach cancer in Poland. In addition the results demonstrated, that dietary practices such as the modality of cooking the food, preparation of food products and storing conditions were connected with stomach cancer risk. These factors have also been found to influence the risk for stomach cancer in Poland. The main message of this latter study was that the family as a whole is affected by many risk factors for stomach cancer and families in which stomach cancer has occurred should be therefore targets for preventive measures. Interestingly, analysis of life style factors such as tobacco smoking or vodka drinking has showed that the risk for cardia cancer increased considerably for smokers of cigarettes without filters and in those who consumed large amounts of vodka. For the non-cardia region a uniform increase of risk could be observed for vodka drinking, regardless of cigarette smoking status. The findings of this study suggested the hypothesis that the effect of tobacco smoking and vodka drinking may be different for cardia cancer compared to the distal cancers. Our clinico-epidemiological study suggest that infection with Helicobacter pylori is not sufficient factor for inducing precancer changes in gastric mucosa. Besides, case-controls studies on dietary habits and physical activity level in the etiology of colorectal cancer are in progress. The preliminary results demonstrated the protective effect of higher physical activity in the occurrence of colorectal cancer after accounting for nutritional habits.

10

Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein

84%

Wyrwicz L. S., Rychlewski L.

Acta Biochimica Polonica

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2008

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tom 55

|

nr 1

The cytomegalovirus (CMV) genome encodes four clusters of genes expressed immediately after infection — i.e.: UL36-38, UL122-123, TRS1-IRS1, and US3. The general function of these genes is associated with inhibition of cellular mechanisms of antiviral response. Although several biological processes have been mapped onto specific gene products, the knowledge of the molecular mechanism of their activity remains fragmentary. Here, we report the application of protein structure prediction methods in assigning the function to a glycosylated domain encoded by UL37 of CMV (gpUL37, UL37x3). The discerned similarity clearly points out that this domain represents a novel type of a major histocompatibility complex (MHC)-like protein, and consequently may play a central role in an additional mechanism of escape from antiviral response.

11

Resistant starch - nutritional and biological activity

84%

Soral-Smietana M., Wronkowska M.

Polish Journal of Food and Nutrition Sciences

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2004

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tom 13/54

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nr Spec.Issue 1

12

Campylobacter protein oxidation influences epithelial cell invasion or intracellular survival as well as intestinal tract colonization in chickens

67%

Lasica A. M., Wyszynska A., Szymanek K., Majewski P., Jagusztyn-Krynicka E. K.

Journal of Applied Genetics

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2010

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tom 51

|

nr 3

The Dsb family of redox proteins catalyzes disulfide bond formation and isomerization. Since mutations in dsb genes change the conformation and stability of many extracytoplasmic proteins, and since many virulence factors of pathogenic bacteria are extracytoplasmic, inactivation of dsb genes often results in pathogen attenuation. This study investigated the role of 2 membrane-bound oxidoreductases, DsbB and Dsbl, in the Campylobacter jejuni oxidative Dsb pathway. Campylobacter mutants, lacking DsbB or Dsbl or both, were constructed by allelic replacement and used in the human intestinal epithelial T84 cell line for the gentamicin protection assay (invasion assay) and chicken colonization experiments. In C. coli strain 23/1, the inactivation of the dsbB or dsbl gene separately did not significantly affect the colonization process. However, simultaneous disruption of both membrane-bound oxidoreductase genes significantly decreased the strain's ability to colonize chicken intestines. Moreover, C. jejuni strain 81-176 with mutated dsbB or dsbI genes showed reduced invasion/intracellular survival abilities. No cells of the double mutants (dsbB⁻ dsbI⁻) of C. jejuni 81-176 were recovered from human cells after 3 h of invasion.

13

Cough reflex sensitivity in children with suspected and confirmed gastroesophageal reflux disease

67%

Varechova S., Mikler J., Murgas D., Dragula M., Banovcin P., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

14

Role of the brain-gut axis in alcohol-related gastrointestinal diseases - what can we learn from new animal models?

67%

Siegmund S., Spanagel R., Singer M. V.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

|

nr 4

191-207

Ethanol exerts multiple actions on nearly all organs of the body, especially on the central nervous system and the gastrointestinal tract. However, little is known about the effects ethanol has on the brain-gut axis, the linkage between the central neural system and the autonomous innervation of the gastrointestinal tract. It is indisputable that ethanol consumption does affect e.g. exocrine pancreatic secretion or intestinal motility, but it is poorly understood, how alcohol consumption may disturb the brain-gut axis and how this may cause damage to gastrointestinal organs. Due to difficulties in directly assessing ethanol effects on the brain-gut axis in humans, animal models represent a versatile tool to study this topic. However, conventional animal models widely utilized in alcohol research, e.g. the Tsukamoto-French model or the Lieber-DeCarli model, do not mimic the human conditions of ethanol consumption and are therefore not suitable for studies of the brain-gut axis. Established models from other alcohol research disciplines, e.g. addiction research, are by far more applicable. Due to this reason, we have established an animal model of alcohol-dependent rats for the use in gastrointestinal alcohol research. In this model, rats are given free access to different of alcohol solutions (5% and 20% v/v) and tap water. Over time, the rats develop signs of alcohol dependence as seen in humans (e.g. deprivation effect). Organs isolated from rats exposed to this model are currently investigated in our laboratory for alcohol-related gene-regulation compared to non-alcoholic littermates. In addition, non-alcoholic components of alcoholic beverages might affect the brain-gut axis or possibly potentiate the toxicity of ethanol. In our model, commonly ingested alcoholic beverages such as beer, wine, cognac, vodka, and whisky and their non-alcoholic constituents will be tested in future animal studies.

15

Schorzenia bydla, trzody chlewnej i owiec powstale na tle zywieniowym

67%

Matzke P.

Biuletyn Informacyjny. Instytut Zootechniki

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1992

|

tom 30

|

nr 3-6

112-120

16

Prospects for the use of probiotic bacteria in the treatment of gastrointestinal diseases in dogs

67%

Chrzastowska M., Kander M., Depta A.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 2

279-284

Probiotic bacteria have been known for over a century. Probiotics are defined as direct feed microbials or microbial cell preparations with a beneficial effect on the health and well-being of the host. Lactobacillus, Bifidobacterium and Enterococcus strains are used most frequently as probiotics. In recent years, their use has increased significantly in both human and veterinary medicine. These bacteria play a significant role in the prevention and treatment of many diseases. Lactobacillus and Enterococcus are capable of colonizing the alimentary tract in dogs. As a result, probiotic bacteria take an important part in the treatment of chronic inflammatory bowel disease.

17

Gastrointestinal diseases among Polish rural population

67%

Schabowski J. P.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

18

Microbiological studies of feed and faeces of fatteners fed mixtures containing naked oat and permutite

67%

Gajewska J., Fabijanska M., Garbolinska M.

Acta Microbiologica Polonica

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2002

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tom 51

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nr 1

19

Zawartość witamin B1, B2 i PP w zestawach dietetycznych przeznaczonych dla leczenia niektórych schorzeń przewodu pokarmowego

51%

Nowicka L., Secomska B.

Roczniki Państwowego Zakładu Higieny

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1958

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tom 09

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nr 4

Ograniczanie wyników

The low-FODMAP diet as an effective tool for managing irritable bowel syndrome – an assessment of adult patients’ knowledge of dietary guidelines

Molecular characterization of Giardia intestinalis detected in humans and water samples in Egypt

Azithromycin in the treatment of a dog infected with Giardia intestinalis

Probiotics in the treatment of gastrointestinal diseases

The influence of anti-TNF therapy on CD31 and VEGF expression in colonic mucosa of Crohn’s disease patients in relation to mucosal healing

Immunoinflammatory responses in gastrointestinal tract injury and recovery

Bronchodilator, vasolidator and spasmolytic activities of methanolic extract of Myrthus communis L.

Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases

Contribution of epidemiology in Poland for better understanding of the natural history of diseases in gastrointestinal tract

Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein

Resistant starch - nutritional and biological activity

Campylobacter protein oxidation influences epithelial cell invasion or intracellular survival as well as intestinal tract colonization in chickens

Cough reflex sensitivity in children with suspected and confirmed gastroesophageal reflux disease

Role of the brain-gut axis in alcohol-related gastrointestinal diseases - what can we learn from new animal models?

Schorzenia bydla, trzody chlewnej i owiec powstale na tle zywieniowym

Prospects for the use of probiotic bacteria in the treatment of gastrointestinal diseases in dogs

Gastrointestinal diseases among Polish rural population

Microbiological studies of feed and faeces of fatteners fed mixtures containing naked oat and permutite

Zawartość witamin B1, B2 i PP w zestawach dietetycznych przeznaczonych dla leczenia niektórych schorzeń przewodu pokarmowego