Wyniki wyszukiwania

1

Aminoacids are involved in exercise and post-exercise muscle metabolism: possible role of very active and strictly transaminative mode of glutamate oxidation found in mitochondria from human gastrocnemius muscle

100%

Matuszkiewicz A.

Polish Journal of Environmental Studies

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1999

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tom 08

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nr 5

2

Changes in contractile properties and action potentials of motor units in the rat medial gastrocnemius muscle during maturation

86%

Dobrzynska Z., Celichowski J.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 1

3

Astragalosides modulates contractile function of toad gastrocnemius muscle

86%

Wei S.-S., Zou Y.-W., Liu Z.-B., Meng W., Zhao K., Wang S.-H., Yao L.-H.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 1

4

Changes in fusion index during the fatigue test of fast motor units in the medial gastrocnemius muscle of the rat

86%

Celichowski J., Grottel K., Bichler E.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 4

5

Differences between properties of male and female motor units in the rat medial gastrocnemius muscle

86%

Celichowski J., Drzymala H.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 1

Differences between motor units in hindlimb locomotor muscles of male and female Wistar rats were studied. The contractile and action potential properties of various types of motor units as well as proportions of these units in the medial gastrocnemius muscle were analyzed. Experiments were based on functional isolation and electrical stimulation of axons of single motor units. Composition of motor units was different for male and female subjects, with higher number of the fast fatigable and lower number of slow type units in male animals. The contraction and the half-relaxation times were significantly longer in male motor units, what might be due to differences in muscle size. Slower contraction of male motor units likely corresponds to lower firing rates of their motoneurons. On the other hand, no significant differences between sexes were observed with respect to force parameters of motor units (the twitch and the maximum tetanus forces), except the fast resistant units (higher force values in male muscles). The mass of the muscle was approximately 1.5 time bigger in male rats. However, the mean ratio of motor unit tetanus force to the muscle mass was almost twice smaller in this group, what indirectly suggests that muscles of male rats are composed of higher number of motor units. Finally, female muscles appeared to have higher fatigue resistance as the effect of higher proportion of resistant units (slow and fast resistant) and higher values of the fatigue index in respective motor unit types. The motor unit action potentials in female rats had slightly lower amplitudes and shorter time parameters although this difference was significant only for fast resistant units.

6

Interspecies differences in the force-frequency relationship of the medial gastrocnemius motor units

86%

Mrowczynski W., Celichowski J., Krutki P.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

Single, functionally isolated motor units were studied in the medial gastrocnemius (MG) muscle of cats and rats. Axons of their motoneurons were stimulated with trains of pulses at frequencies increasing from 1 to 150 Hz and forces developed by muscle fibers were measured and force-frequency curves were compared between species. The following observations were made: (1) the most steep parts of curves (related to unfused tetani of motor units) begun at lower frequencies of stimulations in all types of feline motor units, (2) for fast motor units, the same relative values of force of unfused tetani were achieved at significantly lower frequencies of stimulations in the cat than in the rat. Twitch time parameters of both species influenced the course of force-frequency curves. It was showed that the contraction times of feline units varied in the wide range (21-81 ms), and these units reached 60% of the maximum force at stimulation frequencies between 10 and 38 Hz. On the other hand, contraction times of rat units ranged from 10 to 34 ms, whereas stimulation frequencies necessary to reach 60% of the maximum force varied considerably, from 12 to 65 Hz. The correlations between the above parameters were found for motor units of each species. However, the regression lines drown for the collected population of cat and rat units did not form linear continuity. Thus it seems that interspecies differences in the twitch contraction times do not fully explain different force-frequency relationships in mammalian skeletal muscles.

7

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The influence of increasing and decreasing frequency of stimulation on the contraction of motor units in rat medial gastrocnemius muscle

86%

Celichowski J., Bichler E.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 4,2

8

Chronic kidney disease leads to hypoxia inducible factor-1alpha to hypoxia inducible factor-2alpha switch in the gastrocnemius muscle

72%

Flisinski M., Wisniewska-Chudy E., Brymora A., Stefanska A., Strozecki P., Manitius J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 3

9

Morphometric analysis of muscle fibre types in rat locomotor and postural skeletal muscles in different stages of chronic kidney disease

72%

Flisinski M., Brymora A., Elminowska-Wenda G., Bogucka J., Walasik K., Stefanska A., Strozecki P., Manitius J.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

10

Stereologic studies on mitochondrial configuration in mitochondria of immobilized mice muscle

72%

Cieciura L., Okroj W., Krakowski G.

Folia Histochemica et Cytobiologica

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1984

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tom 22

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nr 1

11

Anatomy of the common calcaneal tendon in horse (Equus caballus)

72%

Szaro P., Witkowski G., Bartyzel B. J., Ciszek B.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2011

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tom 14

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nr 4

12

Tetanic depression in fast motor units of the cat gastrocnemius muscle

72%

Celichowski J., Krutki P., Lochynski D., Grottel K., Mrowczynski W.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 2

Ability of muscle fibers to generate force is decreased when higher frequency of stimulation of motor units immediately follows lower frequency. This phenomenon called tetanic depression was found in rat medial gastrocnemius. However, it was not clear whether tetanic depression occurred only in rat muscle or it concerns all mammals. This study was conducted on motor units of cat medial gastrocnemius. Analyses were made at three successive trains of stimulation: 30 Hz, 20 and 30 Hz and again 30 Hz (the first pattern) or 40 Hz, 25 and 40 Hz and 40 Hz (the second pattern). In all fast units force generated within the middle tetanus was lower than force generated at the same, but constant frequency of stimulation applied earlier or later. The mean tetanic depression in 30 Hz tetani amounted to 10.9% for fast fatigable (FF) and 15.9% for fast resistant (FR) motor units, whereas in 40 Hz tetani mean values were 5.6% and 7.3% for FF and FR motor units, respectively. In slow motor units tetanic depression was not observed. These results proved the existence of tetanic depression in the feline muscle and indicated that its intensity depends on the fusion of tetanus. It has been concluded, that the tetanic depression is a general property of fast motor units in mammals.

13

The number of motor units in the medial gastrocnemius muscle of male and female rats

72%

Celichowski J., Drzymala-Celichowska H.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 4

The number of motor units in the hindlimb locomotor muscle - the medial gastrocnemius - was estimated in male and female Wistar rats by comparison of the whole muscle tetanic force to the mean tetanic force of its motor units. Functional isolation of motor units was achieved by electrical stimulation of single axons from ventral roots of L4 - L5 spinal nerves, while the whole muscle force was measured during stimulation of the sciatic nerve. The medial gastrocnemius muscle is approximately 1.5 times bigger by mass, and is innervated by 10% more motoneurones in males compared to females. Estimation of the force that can be generated by the three types of motor unit in the studied muscle revealed that in both sexes fast fatigable units are responsible for over 60% of the total force output whereas the percentage of the force output contributed by slow units in females is approximately twice that in males. Concluding, the motor innervation of hindlimb skeletal muscles is sexually dimorphic and in the rat male medial gastrocnemius muscle contains about 10% more motor units than in females.

14

Calcium overload increases oxidative stress in old rat gastrocnemius muscle

72%

Capel F., Demaison L., Maskouri F., Diot A., Buffiere C., Patureau Mirand P., Mosoni L.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 3

In order to challenge in vivo muscle Ca2+ homeostasis and analyze consequences on mitochondrial H2O2 release (MHR) and sarcopenia, we injected Ca2+ ionophore A23187 (200 µg/kg, ip) in adult and old rats and measured gastrocnemius mass and mitochondrial Ca2+ content (MCC) using radioactive Ca2+ 48 h after injection. In a second experiment performed in old rats, we measured isocitrate dehydrogenase (ICDH) activity as an index of MCC, MHR, mitochondrial respiration, citrate synthase, COX and antioxydant enzyme activities 24 h after a 150 µg/kg injection. In adult rats, muscle mass and MCC were unchanged by A23187. In old rats, MCC increased 24 h after injection as reflected by a significant increase in ICDH activity; measured MCC tended to increase at 48 h. MHR and Mn-SOD activity were significantly increased at 24 h, and GPX activity was reduced. Muscle mass was unchanged but was negatively correlated with MCC in control and treated old rats. In conclusion, in old rats, A23187 probably induced a mitochondrial Ca2+ overload responsible for the observed increase in MHR without leading to muscle atrophy on a short term basis.

15

Motor units of medial gastrocnemius muscle in the rat during the fatigue test. II. Changes in the time course of sequential tetani of fatigue test

72%

Celichowski J.

Acta Neurobiologiae Experimentalis

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1992

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tom 52

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nr 2

16

Transcriptional dysregulation of skeletal muscle protein metabolism in streptozotocin-diabetic mice

58%

Wieteska-Skrzeczynska W., Grzelkowska-Kowalczyk K., Jank M., Maciejewski H.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 1

29-36

The purpose of the study was to evaluate potential changes in expression of genes involved in protein metabolism and myogenic differentiation markers in skeletal muscle of streptozotocin-diabetic mice. Microarray analysis revealed alterations in the expression of 84 gene transcripts in gastrocnemius muscle of diabetic mice. Regarding protein metabolism a marked downregulation in gene transcripts for: general transcription factor IIA1 (-1.88, P=0.016309), TATA box binding protein (-2.17, P=0.037373), eukaryotic translation initiation factor 4E nuclear import factor 1 (-1.61, P=0.037373), eukaryotic translation elongation factor Iß2 (-1.95, P=0.010406), ubiquitin-like 5 (-1.67, P=0.024975) and ubiquitin conjugating enzyme 7 interacting protein 1 (-1.68, P=0.016309) was observed. STZ-diabetes caused a drop in the expression of myogenin, whereas myostatin level was significantly elevated. In conclusion, 1) STZ-diabetes attenuates expression of gene transcripts involved in the process of transcription and translation, which may affect skeletal muscle protein synthesis and lead to nitrogen imbalance, 2) impaired expression of gene transcripts involved in the regulation and activity of the ubiquitin-proteasome pathway may contribute to attenuation of mechanisms eliminating damaged proteins in STZ-diabetes, 3) changes in the expression of key myogenic factors, manifested by a decrease in myogenin level and enhancement of myostatin expression may be one of the mechanisms limiting skeletal muscle growth and regeneration associated with diabetes.

17

Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats

58%

Testerink J., Degens H., Rittweger J., Shiraishi A., Jaspers R. T., De Haan A.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 1

Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supra-physiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.

18

Effect of cyclooxygenase-2 inhibition by meloxicam, on atrogin-1 and myogenic regulatory factors in skeletal muscle of rats injected with endotoxin

58%

Martin A. I., Nieto-Bona M. P., Castillero E., Fernandez-Galaz C., Lopez-Menduina M., Gomez-Sanmiguel A. B., Gomez-Moreira C., Angeles Villanua M., Lopez-Calderon A.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

19

Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury

58%

Czerwinska A. M., Streminska W., Ciemerych M. A., Grabowska I.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 1

20

Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats

58%

Gomez-SanMiguel A. B., Nieto-Bona M. P., Fernandez-Galaz C., Priego T., Martin A. I., Lopez-Calderon A.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

Ograniczanie wyników

Aminoacids are involved in exercise and post-exercise muscle metabolism: possible role of very active and strictly transaminative mode of glutamate oxidation found in mitochondria from human gastrocnemius muscle

Changes in contractile properties and action potentials of motor units in the rat medial gastrocnemius muscle during maturation

Astragalosides modulates contractile function of toad gastrocnemius muscle

Changes in fusion index during the fatigue test of fast motor units in the medial gastrocnemius muscle of the rat

Differences between properties of male and female motor units in the rat medial gastrocnemius muscle

Interspecies differences in the force-frequency relationship of the medial gastrocnemius motor units

The influence of increasing and decreasing frequency of stimulation on the contraction of motor units in rat medial gastrocnemius muscle

Chronic kidney disease leads to hypoxia inducible factor-1alpha to hypoxia inducible factor-2alpha switch in the gastrocnemius muscle

Morphometric analysis of muscle fibre types in rat locomotor and postural skeletal muscles in different stages of chronic kidney disease

Stereologic studies on mitochondrial configuration in mitochondria of immobilized mice muscle

Anatomy of the common calcaneal tendon in horse (Equus caballus)

Tetanic depression in fast motor units of the cat gastrocnemius muscle

The number of motor units in the medial gastrocnemius muscle of male and female rats

Calcium overload increases oxidative stress in old rat gastrocnemius muscle

Motor units of medial gastrocnemius muscle in the rat during the fatigue test. II. Changes in the time course of sequential tetani of fatigue test

Transcriptional dysregulation of skeletal muscle protein metabolism in streptozotocin-diabetic mice

Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats

Effect of cyclooxygenase-2 inhibition by meloxicam, on atrogin-1 and myogenic regulatory factors in skeletal muscle of rats injected with endotoxin

Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury

Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats