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Extrachromosomal expression of nat05 gene encoding an alkaline serine protease from Bacillus subtilis N05

100%

Thu N. T. A., Chau N. T. T., Thien L. V., Huy N. D., Khue N. T. M., Hung N. B., Luong N. N., Thu L. T. A., Loc N. H.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2018

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tom 99

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nr 4

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N-acetylcysteine modulates effect of the iron isomaltoside on peritoneal mesothelial cells

100%

Misian M., Baum E., Breborowicz A.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 3

3

Screening and characterization of Fibrinolytic protease producing Bacillus circulans from mangrove sediments pitchavaram, South East Coast of India

100%

Sadeesh Kumar R., Rajesh R., Gokulakrishnan S., Subramanian J.

International Letters of Natural Sciences

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2015

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tom 01

Regulation and production of Fibrinolytic enzymes from bacterial sources especially from Bacillus strains has taken a leading role in the medical sciences for the treatment of cardiovascular disorders as it removes thrombus or clots adding to its significant role in curing human health issues saving millions. Significant progress has been made during the last few years on the studies of fibrinolytic enzymes in identifying, cloning, purification, characterization and overproduction of these for commercialization in medical sciences and in fields like detergents development. Production of fibrinolytic enzyme from Bacillus circulans was done using Nutrient broth medium. In addition, a strong fibrinolytic enzyme was purified from the cultivation media. The purified enzyme was almost homogeneous with other species of same genus, as examined by SDS−PAGE and sephadex G-75 column chromatography. The enzyme had an optimal pH of 7-12, an optimal temperature of 50 °C, for fibrin hydrolysis. The molecular mass estimated by gel filtration was 24 to36 KDa. Further studies for characterization and structural elucidation are necessary for their medicinal applications and molecular biological characteristics.

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Influence of ischemic preconditioning on blood coagulation, fibrinolytic activity and pancreatic repair in the course of caerulein-induced acute pancreatitis in rats

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Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Cieszkowski J., Kusnierz-Cabala B., Naskalski J. W., Jaworek J., Konturek S. J., Pawlik W. W., Tomaszewska R.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 2

Previous studies have shown that ischemic preconditioning protects several organs, including the pancreas, from ischemia/reperfusion-induced injury. The aim of the investigation was to determine whether ischemic preconditioning affects the course edematous pancreatitis. Methods: In rats, ischemic preconditioning was performed by short-term clamping the celiac artery. Acute pancreatitis was induced by caerulein. The severity of acute pancreatitis was evaluated between the first and tenth day of inflammation. Results: Ischemic preconditioning applied alone caused a mild pancreatic damage. Combination of ischemic preconditioning with caerulein attenuated the severity of pancreatitis in histological examination and reduced the pancreatitis-evoked increase in plasma lipase and pro-inflammatory interleukin-1ß. This effect was associated with an increase in plasma level of anti-inflammatory interleukin-10 and partial reversion of the pancreatitis-evoked drop in pancreatic DNA synthesis and pancreatic blood flow. In secretory studies, ischemic preconditioning in combination with induction of acute pancreatitis attenuated the pancreatitis-evoked decrease in secretory reactivity of isolated pancreatic acini to stimulation by caerulein. In the initial period of acute pancreatitis, ischemic preconditioning alone and in combination with caerulein-induced acute pancreatitis prolonged the activated partial thromboplastin time (APTT), increased plasma level of D-dimer and shortened the euglobulin clot lysis time. The protective effect of ischemic preconditioning was observed during entire time of experiment and led to acceleration of pancreatic regeneration. Conclusions: Ischemic preconditioning reduces the severity of caerulein-induced pancreatitis and accelerates pancreatic repair; and this effect is related to the activation of fibrinolysis and reduction of inflammatory process.

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Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.III. Wplyw na uklad fibrynolityczny osocza

61%

Jurkowski J., Gacko M., Worowski K.

Bromatologia i Chemia Toksykologiczna

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1995

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tom 28

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nr 2

185-192

Określono wpływ 26 napojów alkoholowych, ich destylatów i pozostałości podestylacyjnych na aktywność fibrynolityczną i kazeinolityczną euglobulin osoczowych i plazminy.

Ograniczanie wyników

Extrachromosomal expression of nat05 gene encoding an alkaline serine protease from Bacillus subtilis N05

N-acetylcysteine modulates effect of the iron isomaltoside on peritoneal mesothelial cells

Screening and characterization of Fibrinolytic protease producing Bacillus circulans from mangrove sediments pitchavaram, South East Coast of India

Influence of ischemic preconditioning on blood coagulation, fibrinolytic activity and pancreatic repair in the course of caerulein-induced acute pancreatitis in rats

Wplyw zwiazkow chemicznych wystepujacych w napojach alkoholowych na hemostaze. Cz.III. Wplyw na uklad fibrynolityczny osocza