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In April 2008 a two-year-old dog of the Leonberger race with symptoms of apathy, loss of appetite and with the temperature 40.1°C was brought to the Veterinary Polyclinic of the University of Warmia and Mazury in Olsztyn The hematological examinations showed a slight thrombocytopenia, and a routinely performed blood smear for the presence of Babesia canis gave a negative result. Despite administering antipyretic and antibiotic, the condition of the patient deteriorated in the following twenty-four hours. The repeated blood tests showed deepening thrombocytopenia, worsening red blood cell indicators and an increase in the activity of alanine aminotransferase and aspartate aminotransferase, as well as the level of urea and creatinin. The repeated blood smear for B. canis gave a positive result at that time. Treatment for babesiosis was applied including the administration of imidocarb, intravenous infusions and diuresis-supporting medicines. In the following days the condition of the dog relapsed in spite of the treatment. Additional symptoms appeared, such as difficult breathing, serous nostril and conjunctival outflow, loss of body weight, pallor of mucous membranes, vomiting, reluctance to move and a deteriorating dyspnea. Blood examinations showed growing leukocytosis and granulocytosis as well as RBC, HGB, HCT and PLT levels remaining considerably below physiological norms. In the blood smear, performed again, the presence of blue-staining inclusion bodies, which were identified as the morula of Ehrlichia canis, was observed in single monocytes. The diagnosis was confirmed with the immunochromatographic test. As a treatment, oxytetracycline was applied intravenously for 7 days, followed by doxycycline administered orally for 5 weeks. The patient’s condition required also the application of full tinned blood, as well as the usage of intravenous infusions and diuretic for several days. During five days from the beginning of the therapy with tetracyclines the clinical condition of the dog and the blood examination results were strongly improved and returned to the physiological norm during two weeks following the end of the antibiotic therapy.
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