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  1. 18 Journal of Physiology and Pharmacology

  2. 4 Journal of Physiology and Pharmacology. Supplement

  3. 2 Folia Histochemica et Cytobiologica

  4. 1 Archivum Immunologiae et Therapiae Experimentalis

  5. 1 Cellular and Molecular Biology Letters

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  1. 4 Gwozdz B.

  2. 4 Josko J.

  3. 4 Slomiany A.

  4. 4 Slomiany B. L.

  5. 3 Goraca A.

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  1. 1 2020

  2. 1 2019

  3. 1 2015

  4. 1 2014

  5. 1 2013

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1
Content available remote

Negative chronotropic effect of endothelin-1 [ET-1] in the cardiac pacemaker tissue

100%
Goraca A.
Journal of Physiology and Pharmacology
|
2003
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tom 54
|
nr 1
The aim of this study was to asses the direct effect of ET-1 on spontaneous discharge rate of the pacemaker tissue in the presence of isoproterenol. The experiments were performed on pacemaker tissue of the isolated right auricle of the right heart atrium of a two-day-old rat. The spontaneous discharge rate of the pacemaker tissue was recorded on the ECG apparatus and analyzed by the computer. ET-1 alone did not significantly affect the discharge rate of the pacemaker tissue. Isoproterenol rapidly increased the discharge rate of the pacemaker tissue. ET-1 had negative chronotropic effect in the presence of isoproterenol. JKC – 301, a blocker of ETA receptors, significantly reduced the negative chronotropic effect of ET-1 in the presence of isoproterenol, whereas IRL – 1038, a blocker of ETB receptors, did not significantly affect the negative chronotropic effect of ET-1 in the presence of isoproterenol. In conlusion, the negative chronotropic effect of ET-1 in the presence of beta-adrenergic stimulation the pacemaker tissue of the right auricle of the right heart atrium of the two-day-old rat is mediated by ETA receptors.
2
Content available remote

Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair

88%
Slomiany B. L., Slomiany A.
Journal of Physiology and Pharmacology
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2005
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tom 56
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nr 4
Leptin, a multifunctional hormone that regulates food intake and energy expenditure, has emerged recently as an important modulator of inflammatory cascades associated with wound healing. In this study, we applied the animal model of buccal mucosal ulcer to investigate the role of endothelin-1 (ET-1) and leptin in soft oral tissue repair. Using groups of rats with experimentally induced buccal mucosal ulcers we show that ulcer onset was characterized by a marked increase in the mucosal level of ET-1 and leptin. However, while the ET-1 level gradually declined with healing, the mucosal level of leptin increased reaching maximum expression on the 4th day of healing. Therapeutic administration of phosphoramidon, an inhibitor of ECE-1 activity, not only led to a 53.2% drop in the ET-1, but also produced a dose-dependent reduction (up to 50.9%) in the mucosal level of leptin and up to 42.3% decline in the rate of ulcer healing. A marked drop (54.2%) in the mucosal level of leptin and the reduction (46.8%) in the rate of ulcer healing was also attained in the presence of ETA receptor antagonist BQ610 administration, but not the ETB receptor antagonist BQ788. Moreover, administration of ERK inhibitor, PD98059 in the presence of ETB receptor antagonist, but not the ETA receptor antagonist, caused the reduction the mucosal leptin level as well as a decline in the rate of ulcer healing. Our findings are the first to implicate the requirement for both ET-1 and leptin in orderly progression of the events of soft oral tissue repair. We also show that ET-1 is a key factor in up-regulation of leptin production associated with oral mucosal ulcer healing , and that the effect of ET-1 on leptin production is a consequence of ETA receptor activation and subsequent signaling through MAPK/ERK.
3
Content available remote

Age dependence of plasma endothelin levels in glaucoma patients

75%
Konieczka K., Terelak-Borys B., Skonieczna K., Schoetzau A., Grabska-Liberek I.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 6
4
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Content available

Expression of endothelin-1, and endothelin A and B receptors in portal hypertensive esophagus of rats

75%
Ohta M., Pai R., Kawanaka H., Ma T., Sugimachi K., Sarfeh I. J., Tarnawski A. S.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 1
5
Content available remote

Cardiac and regional haemodynamic effects of endothelin-1 in rats subjected to critical haemorrhagic hypotension

75%
Jochem J., Zwirska-Korczala K., Gwozdz B., Walichiewicz P., Josko J.
Journal of Physiology and Pharmacology
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2003
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tom 54
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nr 3
In the present study, we examined cardiac and regional haemodynamic effects of endothelin-1 (ET-1), a potent vasoconstrictive factor, in a rat model of pressure-controlled irreversible haemorrhagic shock resulting in the death of all control animals within 30 min. Experiments were carried out in male ethylurethane-anaesthetised Wistar rats subjected to hypotension of 20-25 mmHg, which resulted in bradycardia, an extreme decrease in cardiac index (CI) and an increase in total peripheral resistance index (TPRI), with reductions in renal (RBF), hindquarters (HBF) and mesenteric blood flow (MBF). ET-1 (50, 200 pmol/kg) administered intravenously at 5 min of critical hypotension produced increases in mean arterial pressure (MAP) and heart rate (HR), which were significantly higher than those in normotensive animals, and a 100% survival at 2 h after treatment. The effects were accompanied by a rise in CI, a decrease in TPRI, with increases in RBF and HBF and persistently lowered MBF, and an increase in circulating blood volume 20 min after treatment. The cardiovascular effects of ET-1 were inhibited by the ETA receptor antagonist BQ-123 (1 mg/kg), while the ETB receptor antagonist BQ-788 (3 mg/kg) had no effect. In conclusion, ET-1 acting via ETA receptors produces reversal of haemorrhagic hypotension in rats due to the mobilisation of blood from venous reservoirs, with the improvements in cardiac function and the perfusion of peripheral tissues.
6
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Content available

Cerebral angiogenesis after subarachnoid hemorrhage (SAH) and endothelin receptor blockage with BQ-123 antagonist in rats

75%
Josko J., Hendryk S., Jedrzejowska-Szypulka H., Slowinski J., Gwozdz B., Lange D., Snietura M., Zwirska-Korczala K., Jochem J.
Journal of Physiology and Pharmacology
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2001
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tom 52
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nr 2
7
Content available remote

Role of nitrergic and endothelin pathways modulations in cisplatin-induced nephrotoxicity in male rats

63%
Helmy M. W., Helmy M. M., Abd Allah D. M., Abo Zaid A. M., Mohy El-Din M. M.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 3
8
Content available remote

Concentration of endothelin in plasma and BAL fluid from asthmatic patients

63%
Gawlik R., Jastrzebski D., Ziora D., Jarzab J.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 4
103-110
The bronchoconstrictive peptide endothelin-1 (ET-1) has been demonstrated in the airway epithelial and endothelial cells. In this study we investigated the pathophysiological significance of endothelin-1 in asthma. We addressed the issue by assessing the concentration of ET-1 in plasma and bronchoalveolar lavage fluid (BALF) in patients with a different intensity of asthma. Twenty one asthmatic patients (11 men,10 women) and 6 healthy control subjects (C) were included in the study. Eleven asthmatic patients were classified as moderate persistent asthma (SA), all of them were atopic, and another 10 were mild persistent asthmatics (AA). Lung function tests were carried out in all patients investigated. The ET-1 concentration was determined by an ELISA method in plasma and BALF. We found that the SA patients haed the highest level of ET-1 (SA - 11.4 ±3.6 fmol/ml; AA - 7.1 ±2.7 fmol/ml; C - 5.6 ±1.8 fmol/ml) in BALF. The same concerned the ET-1 level in plasma (SA - 27.8 ±3.8 fmol/ml; AA - 18.1 ±4.3 fmol/ml; C - 17.3 ±3.0 fmol/ml). A positive correlation between the plasma ET-1 level and lung function indices was observed. We conclude that the higher levels of ET-1 in more severe asthma suggest that endothelins may contribute to the pathophysiology of the disease, its severity, and the regulation of bronchial tone.
9

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

63%
Kowalczyk A., Kleniewska P., Kolodziejczyk M., Skibska B., Goraca A.
Archivum Immunologiae et Therapiae Experimentalis
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2015
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tom 63
|
nr 1
10
Content available remote

Mesenteric artery reactivity and small intestine morphology in a chicken model of hypoxia-induced fetal growth restriction

63%
Moonen R. M. J., Kessels C. G. A., Zimmermann L. J. I., Villamor E.
Journal of Physiology and Pharmacology
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2012
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tom 63
|
nr 6
11
Content available remote

Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1

63%
Padilla J., Jenkins N. T.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 5
12
Content available remote

The influence of the low-energy defibrillating impulse on the endothelin-1 concentration in the left heart ventricle and blood serum of the healthy rabbits

63%
Zurawinski W., Kokot T., Swietochowska E., Sosada K., Muc-Wierzgon M.
Journal of Physiology and Pharmacology
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2019
|
tom 70
|
nr 1
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effect of endothelin-1 receptor antagonist BQ-123 on basilar artery diameter after subarachnoid hemorrhage (SAH) in rats

63%
Josko J., Hendryk S., Jedrzejowska-Szypulka H., Slowinski J., Gwozdz B., Lange D., Harabin-Slowinska M.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 2
14
Content available remote

Aging and expression of heme oxygenase-1 and endothelin-1 in the rat carotid body after chronic hypoxia

51%
Di Giulio C., Verratti V., Artese L., Petruccelli G., Walski M., Pokorski M.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 5
15

Natriuretic peptides in cardiovascular diseases

51%
Piechota M., Banach M., Jacon A., Rysz J.
Cellular and Molecular Biology Letters
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2008
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tom 13
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nr 2
155-181
The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.
16
Content available remote

Endothelial-mediated regulation of cerebral microcirculation

51%
McCarron R. M., Chen Y., Tomori T., Strasser A., Mechoulam R., Shohami E., Spatz M.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 11
133-144
Vascular endothelial cells are important not only for maintaining homeostasis, but also in pathogenesis of vascular disorders. Cerebral capillary and microvascular endothelial cells play an active role in maintaining cerebral blood flow, microvascular tone and blood brain barrier functions. Factors produced and released by endothelial cells, other brain cells and circulating blood cells participate in these regulatory functions. In particular, endothelin-1 (ET-1) and nitric oxide (NO) are known to contribute to the functional vascular changes under pathological conditions (e.g., hypertension, arteriosclerosis, and stroke). This report describes the involvement of endothelial cell mediators in the post-ischemic hypoperfusion induced by brain ischemia and in vitro endothelial responses (Ca2+ mobilization and cytoskeletal rearrangements) to ET-1 and its interactions with NO or 2-AG. The capacity of NO and endocannabinoids to counteract ET-1-induced cerebral capillary and microvascular endothelial responses indicates that they may actively participate in EC function and implicates them in physiological and pathophysiological conditions.
17
Content available remote

Influence of nuclear factor-kappaB inhibition on endothelin-1 induced lung edema and oxidative stress in rats

51%
Piechota A., Goraca A.
Journal of Physiology and Pharmacology
|
2011
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tom 62
|
nr 2
The aim of the present study is to determine the effects of the BAY 11-7082, a nuclear factor-kappaB (NF-B) inhibitor, on endothelin-1 (ET-1) induced lung edema, the level of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-) in the lungs. Experiments were carried out on adult male Wistar-Kyoto rats. The animals were divided into 4 groups: Group I: saline-treated control; Group II: saline followed by ET-1 (12.5 µg/kg b.w., i.v.); Group III: BAY 11-7082 (10 mg/kg b.w., i.v.) administered one hour before saline; Group IV: BAY 11-7082 (10 mg/kg b.w., i.v.) administered 1 hour before ET-1 (12.5 µg/kg b.w., i.v.). Injection of ET-1 alone showed a significant (P<0.001) increase in thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (H2O2) level as well as a decrease (P<0.01) in GSH level and GSH/GSSG ratio (P<0.02). BAY 11-7082 significantly decreased TBARS (P<0.01) and H2O2 (P<0.05) level as well as improved the redox status (P<0.02) in the lungs. BAY 11-7082 also prevented ET-1 induced lung edema (P<0.05). The concentration of TNF- (P<0.02) and p65 subunit of NF-B signaling compound (P<0.001) was increased in the presence of ET-1, while BAY 11-7082 decreased both TNF- level (P<0.05) and p65 subunit concentration (P<0.01). Our results indicate that BAY 11-7082 plays a protective role in ET-1 induced oxidative lung injury. It successfully prevents lung edema as well as ROS and TNF- overproduction. Our results also highlight the important role of the NF-B pathway in ET-1 induced lung injury and ROS overproduction.
18
Content available remote

Role of paraventricular nucleus vasopressin V1a receptors in the response to endothelin 1 activation of the subfornical organ in the rat

51%
Rossi N. F., Maliszewska-Scislo M.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
|
nr 8
19
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Endothelin-1, interleukin-4 and nitric oxide synthase modulators of gastric mucosal injury by indomethacin: effect of antiulcer agents

51%
Slomiany B. L., Piotrowski J., Slomiany A.
Journal of Physiology and Pharmacology
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1999
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tom 50
|
nr 2
20
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Role of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: effect of sucralfate

51%
Slomiany B. L., Piotrowski J., Slomiany A.
Journal of Physiology and Pharmacology
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2000
|
tom 51
|
nr 1
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