Contamination of bovine-derived bioproducts with pestiviruses, in particular with bovine viral diarrhea virus, creates a risk of infection for animals and even for humans. Owing to the worldwide spread of pestivirus infections in cattle population, many biological products based on materials derived from cattle or from their tissues are contaminated with this pathogen or contain the viral RNA. Contamination of fetal bovine serum (FBS) by BVDV is an intra-laboratory problem that hinders the diagnostics of infections caused by related viruses, such as classical swine fever virus (CSFV) or hepatitis C (HCV) in humans. Furthermore, vaccines, hormones or other bioproducts used in animals and humans may be contaminated with the virus. The article describes numerous examples of transmission of virulent pestiviruses to susceptible populations through the use of contaminated animal bioproducts.
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