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Background. Shift work may affect the occurrence and severity of hypertension, ischemic heart disease and dyslipidemia. The aim of the study was to assess the prevalence of ischemic heart disease, hypertension and dyslipidemia in shift workers. Material and methods. The study was carried out in the Bogdanka mine in Łęczna, Poland. The questionnaire, which was designed by the author of this work, was conducted among 700 shift workers who worked underground in the mine. Statistical analysis was performed using STATISTICA v. 7.1 (StatSoft, Poland) software. Results. Participants who believed that shift work may lead to deterioration of their health also believed that it may affect the occurrence of ischemic heart disease and hypertension. Almost one in four respondents had blood pressure values of > 139/89 mmHg. Almost one in ten respondents was receiving treatment for hypertension. A small number of respondents reported abnormal total cholesterol, HDL cholesterol and triglyceride levels. Conclusions. In the opinion of respondents, shift work can exacerbate hypertension and ischemic heart disease. Abnormal values of total cholesterol and its LDL and HDL fractions increased with age and length of work, while abnormal triglyceride values were reported most frequently by supervisors. It seems necessary to introduce training for shift workers, aimed at presenting them with the principles of prevention of cardiovascular diseases; for example, how to deal with stress, change eating habits, stop smoking and reduce coffee intake, and how to encourage physical activity and good sleep hygiene.
Zespół metaboliczny (ZM) to stan kliniczny charakteryzujący się współwystępowaniem powiązanych ze sobą czynników, takich jak otyłość brzuszna, zaburzenia lipidowe, nadciśnienie tętnicze oraz upośledzona tolerancja glukozy, zwiększających znacznie prawdopodobieństwo wystąpienia i rozwoju chorób sercowo-naczyniowych, cukrzycy oraz ich powikłań. Częstość obserwowania ZM wzrasta z każdym rokiem, zwłaszcza w krajach wysoko rozwiniętych i rozwiniętych. Brak lub nieskuteczne leczenie ZM skutkuje poważnymi konsekwencjami dla zdrowia populacji oraz wymiernie obciąża system opieki zdrowotnej, stąd celem wielu badań stało się poszukiwanie skutecznych metod prewencji oraz terapii składowych ZM. Oprócz modyfikacji stylu życia oraz terapii lekowej, w postępowaniu terapeutycznym ważną rolę odgrywa modyfikacja diety, a zwłaszcza zmniejszenie podaży nasyconych kwasów tłuszczowych i zastąpienie ich kwasami jedno- i wielonienasyconymi. Wśród wielonienasyconych kwasów tłuszczowych (WNKT), interesującą grupę stanowią sprzężone kwasy tłuszczowe, o wielokierunkowym działaniu prozdrowotnym, których przykładem są sprzężone dieny kwasu linolowego (CLA - conjugated linoleic acids) oraz sprzężone trieny kwasu linolenowego (conjugated linolenic acids - CLnA). W niniejszej pracy dokonano przeglądu piśmiennictwa naukowego dotyczącego właściwości prozdrowotnych sprzężonych kwasów tłuszczowych w kontekście prewencji i terapii schorzeń stanowiących składowe ZM.
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Biliopancreatic diversion in Poland

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Biliopancreatic diversion (BPD) is a bariatric operation of proved efficacy especially in patients with metabolic comorbidities. The aim was to assess the results of BPD in relation to weight loss and coexisting lipid and glucose metabolism disturbances in the Polish population. Between October 2001 and December 2003 57 morbidly obese patients (24 male and 33 female) underwent BPD. Median age was 46 years (range: 17-58) and median body mass index (BMI) was 50.2 kg/m2 (range: 40.1-73 kg/m2). Type 2 diabetes mellitus was observed in 11 patients (19.3%), hypercholesterolaemia in 38 patients (66.7%) and hypertriglyceridaemia in 37 patients (64.9%). Median value of BMI decreased at three months to 40.0 kg/m2, at six months to 36.7 kg/m2, and after a year to 32.3 kg/m2. Diabetes was completely resolved in all patients. After six months, triglycerides and cholesterol levels were higher than normal only in one patient. Early specific complications that manifested as seroma and nosocomial pneumonia occurred in 5.3% and 3.5% patients, respectively. The following specific late complications were observed: ulceration of stomach stump (3.4%), anaemia (14.0%), hypoalbuminaemia (8.8%), deterioration of haemorrhoids (15.8). All of above complications were treated conservatively expect two haemorrhoidectomies. One patient died due to myocardial infarction eight months after BPD. Five cases of incisional hernias (8.8%) were found. BPD is an effective bariatric procedure also in the Polish population, resulting not only in weight loss but also in the improvement of lipid and glucose metabolism.
Gestational weight gain (GWG) is important for health policy as it may be associated with overweight epidemics in childhood and adolescence. The purpose of the study was to perform the risk assessment of joint effects of the excessive GWG and the pregravid maternal BMI on overweight in infancy and childhood. The observations were collected in the ongoing prospective birth cohort study of 482 non-smoking mothers and their newborns in Cracow inner city area. At 5 years of age the subsample of 312 infants were reexamined in order to assess their nutritional status. Body fatness was assessed by means of the weight/length ratio (WLR) in neonates and weight/height ratio (WHR) in 5-year-olds since they showed the strongest correlation with subcutaneous fat mass of young children. In the statistical analysis the binary regression models were applied to identify predictors of overweight. The excessive GWG (>18 kg) increased more than twofold the adjusted relative risk (RR) of neonatal fatness (R=2.7; 95% CI 2.0-3.7) and was also a significant independent risk factor for postnatal body fatness at 5 years of age (RR=2.0; 95% CI: 1.3-3.3). The results confirmed earlier findings that pregravid overweight increased not only the relative risk of neonatal fatness (RR=2.9; 95% CI: 2.2-3.9) but also overweight in early childhood (RR=2.7; 95% CI: 1.7-4.4). The conclusion is that excessive GWG may be a risk factor for overweight in early childhood and should be a focus of public health policy.
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Mice with the knockout of endothelial nitric oxide synthase (eNOS ko) demonstrate symptoms resembling the human metabolic syndrome. NO has been recently demonstrated to be deeply involved in regulation of not only blood flow and angiogenesis, but also in modulation of mammalian basal energy substrate metabolism. Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of NOS. The enzyme dimethylarginine dimethylaminohydrolase (DDAH) catabolizes ADMA, what leads to increase of endogenous NO bioavailability. This study was aimed to compare the brown (BAT) and white (WAT) adipose tissue gene expression of age matched mice with decreased (eNOS ko) and increased (overexpressing DDAH) endogenous NO generation. The 19 week old eNOS ko mice demonstrated significantly lower weight, higher circulating glucose, insulin, leptin and cholesterol concentrations. The adiponectin as well as fasting triglyceride concentrations were not significantly altered. Animals with DDAH knock in, presented significantly increased angiogenic activity than eNOS ko mice. The microarray analysis pointed to activation of adipogenesis-related genes in eNOS ko mice in WAT, what was in contrast with the inhibition observed in the DDAH overexpressing mice. The angiogenesis related gene expression was down-regulated in both models in comparison to WT animals. This study support the multipotential role of endogenous NO in maintaining homeostasis of energy substrate catabolism.
The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.
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