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Three interesting cases of syndrome of inappropriate antidiuretic hormone secretion

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Dyczko M., Sawa M., Grzywa-Celinska A., Szmygin-Milanowska K., Kuczynska M., Mosiewicz J.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 2

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an etiologically-diverse pathological condition resulting from the elevation in both ectopic and autonomic secretion of the antidiuretic hormone (ADH) by neoplastic tissue; excessive stimulation of the hypothalamic-pituitary axis, e.g. in pulmonary diseases, central nervous system (CNS) abnormalities, endocrine glands dysfunction or due to the use of some medications; intensification of renal ADH action by certain medications and action of substances chemically-related to vasopressin. The clinical characteristics of the syndrome are comprised of the presence of inadequately concentrated urine, hyponatremia, and hypo-osmolal blood serum, as well as weight gain. To show the variety of its causes and courses the article presents three cases of patients diagnosed with SIADH in the Department of Internal Medicine. In each of them the syndrome of inappropriate antidiuretic hormone secretion manifested in clinical laboratory tests in the form of hyponatremia.

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The effect of acid adaptation conditions on heat resistance of Escherichia coli O157:H7

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Tosun H., Gonul S. A.

Polish Journal of Microbiology

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2005

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tom 54

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nr 4

The objective of this study was to determine the effect of acid adaptation conditions on heat resistance of E. coli 0157: H7 932. E. coli 0157: H7 was adapted to acid by exposing the cells to pH 4.5 (2h), pH 5.0 (lh), and pH 5.5 (1h) in tryptic soy broth. D and z values of the acid adapted and control cultures at 54°C, 56°C, and 58°C were determined in E buffer. The heat resistance of E. coli 0157: H7 increased significantly (p<0.05) after acid adaptation at pH 4.5 or pH 5.0. E. coli 0157: H7 adapted to acid at pH 4.5 for 2 h had the highest D values at all temperatures tested (20.3-10.7-3.3 min) while D values of culture adapted to acid at pH 5.0 for 1h were 18.2, 7.9, and 2.6 min at 54°C, 56°C and 58°C, respectively. Heat resistance of culture adapted to acid at pH 5.5 for 1h and the control culture was not significantly different (P<0.05). Culture adapted to acid at pH 4.5 had the highest z value (5.10°C), whereas control culture had the lowest z value (4.33°C). This study showed that the magnitude of heat tolerance changed with the adaptation pH and at low adaptation pH, E. coli 0157: H7 showed maximum heat resistance. Acid adaptation at pH 4.5 or 5.0 provides E. coli 0157: H7 with cross-protection against heat treatments, and that this factor must be considered to estimate this pathogen's thermal tolerance accurately.

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Paraneoplastic syndromes in daily clinical practice

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Wojtowicz M., Rekas-Wojcik A., Lipa A., Prystupa A., Dzida G.

Journal of Pre-Clinical and Clinical Research

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2014

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tom 08

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nr 2

Paraneoplastic syndromes consist of disorders that accompany benign and malignant tumours, but are not directly related to mass effects or invasion by the primary tumour or its metastases. The pathophysiology of mostly paraneoplastic syndromes is not well known. The usual mechanism of their development is the aberrant production of substances (protein hormones, hormone precursors or hormone-like substances) by tumour tissue or autoimmune disorder. The neurological paraneoplastic syndromes are autoimmune disorders that can affect almost any part of the nervous system. The endocrine paraneoplastic syndromes are often certain clinical syndromes like paraneoplastic hypercalcaemia or the aberrant production of hormones by cancers. Many haematologic conditions, including anaemia, leucocytosis, thrombocytopenia or thrombocytosis, coagulapathy have been reported in association with cancer. Also paraneoplastic rheumatic syndromes have been reported in association of cancer. Skin can be involved in cancer in different ways: by metastases, as a part of a genetic disorder with a cutaneous component in which there is an inherited predisposition to the later development of malignancy, as a part of an acquired syndrome due to the toxicity of a carcinogen that induces malignant change and accompanying skin changes, as a consequence of immunosuppression, or by the development of specific lesions that occur as a paraneoplastic syndromes The most frequently diagnosed dermatologic conditions include acrokeratosis paraneoplastica, Sweet’s syndrome and paraneoplastic pemphigus. The purpose of this article is to describe the most popular in internal clinical practice neurologic, endocrine, haematologic, rheumatologic and dermatologic paraneoplastic syndromes associated with cancer.

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Back pain as a factor of disability in women over 50 from Biala Podlaska and the surrounding areas

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Pocztarska-Glos A., Sidor M., Gawlik K., Bergier B., Stepien E., Baj-Korpak J., Szepeluk A.

Health Problems of Civilization

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2019

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tom 13

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nr 4

Background. Chronic back pain is one of the most common causes of disability. It is a civilisation disease and up to 75% of women over the age of 55 suffer from it. The aim of this study was to assess the degree of disability and limitations in the daily functioning of women with lumbar spine pain depending on socio-demographic factors. Material and methods. The study included a group of 274 professionally active women aged between 50 and 64 who come from Biała Podlaska, Poland, and the surrounding areas and who completed the Oswestry Disability Index. The responses showed functional limitations of the respondents during performing specific activities due to back pain. The respondents were characterised with regard to their age, place of residence, education and material status. The results were analysed statistically. Results. The most numerous group included women with moderate disability – 41.6%. Lower back pain intensifies when sitting, standing, walking, lifting objects and applies mainly to women from the oldest age group, women having secondary and lower education, women from the city and those whose financial situation is below the average. Conclusions. A socio-demographic factor that differentiates the degree of the women’s disability in a significant way is their material status – the better the financial situation, the less severe the disability. Socio-demographic factors – such as age, education and material status – are strong determinants of functional limitations caused by back pain: women from the oldest age group (60-64 years old) had the biggest problem with walking; women with secondary or lower education experienced difficulty sitting and walking; women whose financial situation is below the average suffered much more difficulties while lifting objects, sitting and socialising.

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Joint hypermobility in fibromyalgia patients has no impact on tests for disease severity

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Ribel-Madsen S., Bartels E. M., Gronemann S. T., Danneskiold-Samsoe B., Bliddal H.

Journal of Pre-Clinical and Clinical Research

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2008

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tom 02

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nr 2

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Production of monoclonal antibodies specific to avian pneumoviruses

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Bartnicka B., Minta Z.

Bulletin of the Veterinary Institute in Puławy

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1997

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tom 41

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nr 2

Monoclonal antibodies (MAbs) specific to avian pneumoviruses were obtained for the diagnosis of turkey rhinotracheitis (TRT) and swollen head syndrome (SHS). The vaccinal BUT strain of TRT virus was used as an antigen for mouse immunisation. The virus was propagated in a Vero cell culture followed by purification and concentration by ultracentrifugation. The obtained antigen was used for threefold Balb/c mouse immunisation. The spleen from a mouse with the highest anti-TRT antibody level was sampled. Fusion of splenic cells with Sp2/0-Ag 14 myeloma cells was conducted in the presence of PEG-1450. The ELISA and peroxidase-linked assay (PLA) were used to detect antibodies specific to TRT virus in the sera of immunised mice, in the supernatant of hybridoma cell cultures and in the ascitic fluid of mice. The antigenic specificity of MAbs was determined by the immunoblotting technique and their isotype by agar gel immunodifusion method and ELISA. Seven secretive clones were obtained from 2 fusions. The MAbs produced by the clones were detected by the PLA and in the case of 3 clones the ELISA was used. One clone secreted the IgG2a and the remaining clones the lgG1 immunoglobulines. All MAbs recognised the surface G glycoprotein. The MAbs obtained were successfully used to distinguish the Polish avian pneumovirus APV isolates and to detect the virus in the tissues of the respiratory system of chickens infected experimentally.

Ograniczanie wyników

Three interesting cases of syndrome of inappropriate antidiuretic hormone secretion

The effect of acid adaptation conditions on heat resistance of Escherichia coli O157:H7

Paraneoplastic syndromes in daily clinical practice

Back pain as a factor of disability in women over 50 from Biala Podlaska and the surrounding areas

Joint hypermobility in fibromyalgia patients has no impact on tests for disease severity

Production of monoclonal antibodies specific to avian pneumoviruses