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1

The effect of dimethoate and pyrantel embonate intoxication on selected elements of antioxidative barrier in rats

100%
Wysocki A., Zasadowski A.
Acta Toxicologica
|
2005
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tom 13
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nr 2
2

Changes in acetylcholinesterase activity in rats intoxicated with dimethoate and pyrantel embonate

100%
Wysocki A., Zasadowski A.
Acta Toxicologica
|
2005
|
tom 13
|
nr 1
3
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Prenatal toxicity of dimethoate in hamsters, rats and rabbit

100%
Minta M., Biernacki B., Wlodarczyk B.
Bulletin of the Veterinary Institute in Puławy
|
1995
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tom 39
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nr 2
4

Effect of pyrantel and dimethoate administration on rat liver cytochrome P450 system

100%
Wiaderkiewicz R., Zasadowski A., Czekaj P., Wiaderkiewicz A., Czajkowska B., Barski D., Palasz A.
Bulletin of the Veterinary Institute in Puławy
|
2006
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tom 50
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nr 2
5

Influence of Bi 58 Nowy (38% dimethoate) on pyrantel embonate concentration in the liver of rats

84%
Barski D., Zasadowski A.
Polish Journal of Veterinary Sciences
|
2009
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tom 12
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nr 4
The aim of the study was to determine the concentration of pyrantel residues in the liver of rats in different time points after oral administration of pyrantel embonate as well as combined administration of the Bi 58 Nowy preparation (38% of dimethoate) and pyrantel embonate. The experiment was conducted in two stages involving different doses of compounds and modes of exposure. At the first stage, the animals were administered pyrantel embonate with a stomach tube at a dose of 1000 mg/kg b.w. twice in a two-week interval, i.e. on day 14 and 28, and the Bi 58 Nowy preparation with drinking water at a dose of 15.48 mg/kg b.w. for 28 days. At the second stage, the rats received pyrantel embonate at a dose of 400 mg/kg b.w. with a stomach tube for 3 consecutive days, whereas the Bi 58 Nowy preparation was administered at a dose of 38.7 mg/kg b.w. also with a stomach tube for 5 consecutive days. In the rats doubly administered with pyrantel embonate, its residues were present until day 14, whereas when the drug was administered for 3 consecutive days they were present until day 7 of the experiment. The maximum concentration of pyrantel embonate was found in the liver after the 3rd hour, whereas a considerable decrease occurred between the 3rd and the 12th hour. The combined administration of pyrantel embonate and the Bi 58 Nowy preparation caused a significant decrease in the concentration of pyrantel residues in the liver 3 and 6 hours after exposure, as compared to the rats receiving the drug alone.
6

Influence of dimethoate on pyrantel concentration in rat liver

84%
Zasadowski A., Barski D., Piekoszewski W.
Bulletin of the Veterinary Institute in Puławy
|
2006
|
tom 50
|
nr 3
7

The effect of dimethoate and pyrantel on vitamin C concentration in the rat liver

84%
Spodniewska A., Zasadowski A.
Polish Journal of Veterinary Sciences
|
2006
|
tom 09
|
nr 1
The aim of this study was to determine the content of vitamin C in the liver of rats exposed to dimethoate or pyrantel embonate as well as co-intoxication with both agents. Investigations were carried out in two stages. At each stage, the rats were divided into three experimental groups (I-III) and a control (C) group. In the first stage, rats from group I were administered pyrantel embonate at a two-week interval at a dose of 1/2 LD50, while the animals from group II received dimethoate for 28 days at a dose of 1/25 LD50, and those from group III - both mentioned compounds in an identical manner as in groups I and II. In the second stage, the rats from group I received pyrantel embonate at a dose of 1/5 LD50 for 3 consecutive days, while the animals from group II received dimethoate at a dose of 1/10 LD50 for 5 consecutive days, and those from III received both compounds, but pyrantel was administered on day 3, 4 and 5 of dimethoate administration. The concentration of vitamin C after pyrantel embonate and dimethoate administration was influenced not only by doses of the compounds used but also by the manner of their application (single or co-administration). Dimethoate delivered at a dose of 1/25 LD50 evoked an increase in vitamin C concentration that was observed to continue up to the 14th day after the exposure, whereas when applied at a dose of 1/10 LD50 it increased the vitamin C level only at the 3rd hour. A considerable decrease in the vitamin C level was reported after pyrantel treatment at a dose of 1/5 LD50. In rats from groups where the compounds were co-administered, increased level of vitamin C was observed at both stages of the experiment only in the first period after intoxication, i.e. up to the 6th hour.
8

Residues of dimethoate in the liver and AChE activity in blood of rats after exposure to dimethoate, and dimethoate and pyrantel embonate

84%
Barski D., Zasadowski A.
Polish Journal of Veterinary Sciences
|
2006
|
tom 09
|
nr 1
The study was aimed at determining the dimethoate residues in the liver and acetylcholinesterase (AChE) activity in blood of rats exposed to dimethoate (individual intoxication), and dimethoate and pyrantel embonate (simultaneous intoxication). The experiment was carried out in two stages where various doses of preparations and exposure manners were used. In the first stage of the experiment, dimethoate (1/25 LD50) was administered to animals per os for 28 days, and pyrantel embonate (1/2 LD50) twice, i.e. on the day 14th and 28lh. In the second stage, dimethoate was administered for 5 days (1/10 LD50), and pyrantel embonate (1/5 LD50) on day 3, 4 and 5 from the beginning of dimethoate intoxication. The short presence of the dimethoate residues in the liver of the animals examined was found until the 2"d day after 28-day intoxication (1/25 LD50) and until 14th day after 5-day intoxication (1/10 LD50), however, a distinct decrease in this insecticide residues in the liver of (analysed groups of) rats occurred between the 3rd hour and the 2nd day after exposure. Dimethoate in both applied doses significantly reduced AChE activity in blood. After application of the higher dose, the inhibition of AChE was more pronounced, and the return of its activity to physiological values lasted considerably longer. Co-administration of pyrantel embonate and dimethoate, slightly influenced changes of the parameters analysed, which have been dependent not only on a dose and manner of pyrantel application but also on time which lapsed from exposure.
9

Influence of dimethoate on the structure and function of the natural phytoplankton assemblage of the Darss-Zingst bodden chain reared in a laboratory

84%
Mohapatra P. K., Schiewer U.
Polish Journal of Environmental Studies
|
1996
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tom 05
|
nr 2
The toxic effect of the organophosphorus (OP) insecticide dimethoate on the structure and function of natural phytoplankton assemblage of brackish lake water of the Darss-Zingst bodden chain was tested in a laboratory under both short- and long-term incubation. A decrease in photosynthetic activity, an increase of photosystem II (PS II) fluorescence emission and acceleration of respiratory O2 consumption were observed as immediate responses (1 h treatment) by the sample to the OP insecticide taken at concentrations of up to 1 mg/1. Long-term exposure (8 days) of the phytoplankton assemblage to the chemical caused elimination of the sensitive species, a change in phytoplankton density and diversity, a decrease of photosynthetic activity and differential fluorescence responses of PS II. A direct relation to the number of eliminated species with insecticide concentrations and days of incubation was observed. All the tested concentrations were found to be toxic to the phytoplankton assemblage albeit acceleration of growth of certain species at 0.01 mg/1 of the insecticide. The monitoring of the fluorescence response cf PS II and respiratory O2 consumption were considered convincing parameters for short-term toxicity assessment while photosynthetic efficiency and phytoplankton diversity were found to be better indicators of long-term toxicity exposure.
10
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Time and temperature dependent sorption behaviour of dimethoate pesticide in various Indian soils

67%
Rani S., Sud D.
International Agrophysics
|
2014
|
tom 28
|
nr 4
Experiments were conducted to study the sorption behaviour of dimethoate in three Indian soils at different temperatures. A kinetic study showed that adsorption equilibrium was reached within 15 h at different initial levels of pesticide concentration. Applicability of the pseudo second order kinetic model suggested that the adsorption process was complex and several mechanisms were involved. The Freundlich model explained the adsorption behaviour adequately and the isotherms were of S-type. The adsorption process was found to be strongly affected by temperature. The Gibbs free energy change, ΔGº values (from -15.81 to -16.60 kJ mol-1) indicated that the process was spontaneous and exothermic in nature. The change in enthalpy of adsorption, ΔH° values (from -17.729 to -21.539 kJ mol-1) suggested that relatively weak H-bond forces were the main driving forces for adsorption. Desorption was found to be concentration- and temperature-depen- dent with higher desorption occurring at higher temperature and concentration levels. The results signify the importance of temperature in controlling the mobility of dimethoate in water bodies.
11

Activity of superoxide dismutase and catalase in erythrocytes and malondialdehyde concentration in the liver of rats exposed to Bi 58 Nowy and pyrantel

67%
Barski D., Zasadowski A.
Bulletin of the Veterinary Institute in Puławy
|
2008
|
tom 52
|
nr 2
The effect of an administration of Bi 58 Nowy (38% dimethoate) and/or pyrantel embonate on the activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and on malondialdehyde (MDA) concentration in rat liver homogenates was investigated. Bi 58 Nowy was administered for 4 weeks with drinking water at a dose of 15.48 mg/kg b.w. (1/25 LD₅₀). Pyrantel embonate was given with a stomach probe at a dose of 1 000 mg/kg b.w., twice at two-week interval, i.e. on days 14 and 28. It was found that a 4-week exposure of rats to Bi 58 Nowy resulted, especially during the first hours after exposure, in an increase in SOD and CAT activity in erythrocytes and MDA content in rat liver homogenates, as compared to the control group. This may indicate that oxidative stress has appeared. The profile of changes in the examined parameters in combined intoxication was similar to those that were observed after the administration of only Bi 58 Nowy, but the changes were more pronounced.
12

Effect of two insecticides dicofol and dimethoate on the growth of Streptomyces atroolivaceus, a rhizosphere strain promoting plant growth

51%
El-Shanshoury A. R.
Acta Microbiologica Polonica
|
1995
|
tom 44
|
nr 2
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